Dopaminergic contributions to the visual categorization of natural scenes: evidence from Parkinson's disease

Antal, Andrea; Kéri, Szabolcs; Kincses, Zsigmond Tamás; Dibó, Gábor; Szabó, Attila; Benedek, György; Janka, Zoltán; Vécsei, László

doi:10.1007/s00702-003-0833-9

Cited by 16 publications

(5 citation statements)

References 65 publications

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“…Overall, the results of this study add to the growing evidence that various aspects of semantic processing may be compromised in PD [2, 3, 36, 37]. The results also support previous suggestions that disruptions to the signal-to-noise ratio may influence semantic processing in PD [19], and illustrate that such changes to the signal to noise ratio can have a differential impact on automatic and controlled aspects of semantic activation.…”

Section: Discussionsupporting

confidence: 86%

The Influence of Dopamine on Automatic and Controlled Semantic Activation in Parkinson's Disease

Arnott

Copland

Chenery

et al. 2011

Parkinson's Disease

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Two semantic priming tasks, designed to isolate automatic and controlled semantic activation, were utilized to investigate the impact of dopamine depletion on semantic processing in Parkinson's disease (PD). Seven people with PD (tested whilst on and off levodopa medication) and seven healthy adults participated in the study. The healthy adult participants demonstrated intact automatic and controlled semantic activation. Aberrant controlled semantic activation was observed in the PD group on levodopa; however, automatic semantic activation was still evident. In contrast, automatic semantic activation was not evident in the PD group off levodopa. These results further clarify the impact of PD on semantic processing, demonstrating that dopamine depletion can cause disturbances in both automatic and controlled semantic activation.

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Section: Discussionsupporting

confidence: 86%

The Influence of Dopamine on Automatic and Controlled Semantic Activation in Parkinson's Disease

Arnott

Copland

Chenery

et al. 2011

Parkinson's Disease

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“…PD patients require various cognitive abilities to recognize facial expressions, but they display a wide spectrum of nonmotor problems, for example, in visuospatial function [ 35 , 36 ], working memory [ 37 – 40 ], decision making [ 41 , 42 ], and categorization [ 43 ]. Without using a suitable control task, it would be difficult to determine whether PD patients' poor performance on our emotional task in Experiment 1 was due to an inability to discriminate emotions or to deficits in the many relevant cognitive abilities.…”

Section: Introductionmentioning

confidence: 99%

Degraded Impairment of Emotion Recognition in Parkinson’s Disease Extends from Negative to Positive Emotions

Lin

Tien

Huang

et al. 2016

Behavioural Neurology

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Because of dopaminergic neurodegeneration, patients with Parkinson's disease (PD) show impairment in the recognition of negative facial expressions. In the present study, we aimed to determine whether PD patients with more advanced motor problems would show a much greater deficit in recognition of emotional facial expressions than a control group and whether impairment of emotion recognition would extend to positive emotions. Twenty-nine PD patients and 29 age-matched healthy controls were recruited. Participants were asked to discriminate emotions in Experiment 1 and identify gender in Experiment 2. In Experiment 1, PD patients demonstrated a recognition deficit for negative (sadness and anger) and positive faces. Further analysis showed that only PD patients with high motor dysfunction performed poorly in recognition of happy faces. In Experiment 2, PD patients showed an intact ability for gender identification, and the results eliminated possible abilities in the functions measured in Experiment 2 as alternative explanations for the results of Experiment 1. We concluded that patients' ability to recognize emotions deteriorated as the disease progressed. Recognition of negative emotions was impaired first, and then the impairment extended to positive emotions.

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“…The fovea is covered by the highest density of neurons in the retina and visual cortex and provides the neural substrate for visual recognition. Conversely, beyond the retina, neuropsychological, electrophysiological, and imaging studies document higher order cognitive dysfunction in PD subjects even without dementia (Bodis-Wollner et al, 1995; Antal et al, 2002, 2003; Antal, Pfeiffer, & Bodis-Wollner, 1996).…”

mentioning

confidence: 99%

Fovea and foveation in Parkinson's disease.

Bódis-Wollner¹,

Glazman²,

Yerram³

2013

Behavioral Neuroscience

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Nondemented Parkinson's disease (PD) patients report problems on nonmotor tasks that depend on visual or visuospatial abilities. In PD, foveal vision is impaired. Experimental studies in humans and monkeys established that foveal processing and visuospatial attention may be linked through saccadic eye movements. Saccadic eye movements "bring" eccentric targets to the direct sight line for closer scrutiny by foveal processing. This is called foveation. This review musters the arguments for impaired foveal vision and impaired cortical control of voluntary saccades in PD. Retinal impairment of spatial contrast vision is selective in PD. Thus, the reviewed literature includes a brief survey of the physiology of foveal pathways. This is necessary to understand the specificity of the retinopathy of PD, documented by clinical evidence, relying on psychophysical, electrophysiological, and imaging techniques. These have recently been supplanted by the results of retinal imaging using Optical Coherence Tomography (OCT). Studies of cortical mechanisms in PD reviewed here relied on neuropsychological, electrophysiological (EEG), and imaging techniques. Impaired functional anatomy and electrophysiology in PD are reviewed. The exact relationship of retinal foveal deficits and visuospatial attention and postural control impairment in PD remain challenging research questions. This review will hopefully will provide useful material for future studies.

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Dopaminergic contributions to the visual categorization of natural scenes: evidence from Parkinson's disease

Cited by 16 publications

References 65 publications

The Influence of Dopamine on Automatic and Controlled Semantic Activation in Parkinson's Disease

The Influence of Dopamine on Automatic and Controlled Semantic Activation in Parkinson's Disease

Degraded Impairment of Emotion Recognition in Parkinson’s Disease Extends from Negative to Positive Emotions

Fovea and foveation in Parkinson's disease.

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