2006
DOI: 10.1523/jneurosci.1767-06.2006
|View full text |Cite
|
Sign up to set email alerts
|

Dopaminergic Control of Sleep–Wake States

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

14
220
1
1

Year Published

2008
2008
2016
2016

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 284 publications
(236 citation statements)
references
References 64 publications
14
220
1
1
Order By: Relevance
“…It is a cofactor for tyrosine hydroxylase and is integral to D2 receptor function 27 . Neuromodulation by the DA system plays an important role in sleep regulation, including the modulation of REM sleep quality, quantity, and timing 28,29 . Holst et al 30 , studied sleep-wake regulation in humans and combined pharmacogenetic and neurophysiologic methods to analyze the effects of the 3′-UTR variable-number-tandem-repeat polymorphism of the gene (DAT1, SLC6A3) encoding dopamine transporter.…”
Section: Methodsmentioning
confidence: 99%
“…It is a cofactor for tyrosine hydroxylase and is integral to D2 receptor function 27 . Neuromodulation by the DA system plays an important role in sleep regulation, including the modulation of REM sleep quality, quantity, and timing 28,29 . Holst et al 30 , studied sleep-wake regulation in humans and combined pharmacogenetic and neurophysiologic methods to analyze the effects of the 3′-UTR variable-number-tandem-repeat polymorphism of the gene (DAT1, SLC6A3) encoding dopamine transporter.…”
Section: Methodsmentioning
confidence: 99%
“…to distinguish between Wake and nreM sleep, we initially considered choices of ratio 2 that focused on the delta band (2-4 hz), but the separation of clusters was optimal when we included all eeg activity between 0.3 and 20 hz as shown in previous state space work. 14,15 We defined ratio 1 as 6.5-9/0.3-9 Hz to emphasize high theta (6.5-9 Hz) frequencies because activity in this range dominates rodent reM sleep, and dysregulation of reM sleep is an important aspect of the narcolepsy phenotype. Note that the choice of frequency bands for ratio 1 (6.5-9 Hz) is slightly different from those proposed by gervasoni et al and empirically resulted in a better cluster separation for our data set.…”
Section: Construction Of the Two-dimensional State Space And Definitimentioning
confidence: 99%
“…consistent with this trend, state space analysis provides a novel, non-categorical method for analyzing sleep/wake behavior. [14][15][16] By enabling visualization of behavioral states as a continuum, state space analysis captures the richness of physiology better than conventional, categorical scoring of sleep/wake behavior. for example, the state space approach revealed clear differences in the depth of Wake and nreM sleep of OXKO mice that were not apparent with traditional spectral analysis, possibly because in these analyses transitional data is often excluded or diluted through averaging and because the state space approach employs the ratio of two frequency bands rather than a single frequency band.…”
Section: Advantages Of the State Space Techniquementioning
confidence: 99%
See 1 more Smart Citation
“…When maintained in isolation, DAT-KO mice exhibit increase in reactivity and aggression when submitted to social interactions [2]. DAT-KO mice also present deficits in odor recognition [13] and impairment in the normal wake-sleep cycle [25]. Using DAT-KO, Morice et al showed that these animals had impairment in the water-maze paradigm, and long-term depression [9].…”
mentioning
confidence: 99%