Dopaminergic Control of the Feeding Circuit

Baik, Ja Hyun

doi:10.3803/enm.2021.979

Cited by 26 publications

(15 citation statements)

References 75 publications

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“…After the establishment of this baseline feeding curve, we gave the mice access to more palatable high fat diet (HFD) (Figures 1E,F). We chose to provide the mice with about one-half of the amount of daily caloric intake worth of HFD to avoid Frontiers in Physiology frontiersin.org over-eating of the mice with harmful metabolic consequences (Coccurello and Maccarrone 2018;Baik 2021). Due to the construction of the feeding cubes (Figure 1A), the mice had to eat first the HFD before having access to normal diet (ND) ad libitum.…”

Section: Resultsmentioning

confidence: 99%

“…This finding was another demonstration of the power of more palatable food to override the inhibitory signals from the homeostat system, especially, when this kind of food was given during the rest phase of an animal. It has been suggested that continuous food uptake at the wrong phase, i.e., the rest phase, increased the risk of developing metabolic syndrome and obesity ( Coccurello and Maccarrone 2018 ; Baik 2021 ). An interesting therapeutic approach has been developed based on these observations.…”

Section: Discussionmentioning

confidence: 99%

“…However, the homeostatic component is by far not the only decision process involved. More palatable food triggers the mesolimbic reward system to release dopamine ( Zhou and Palmiter 1995 ; Baik 2021 ). This strong pleasure signal can overcome the block of food searching imposed by the brainstem.…”

Section: Introductionmentioning

confidence: 99%

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Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice

et al. 2022

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Searching for food follows a well-organized decision process in mammals to take up food only if necessary. Moreover, scavenging is preferred during their activity phase. Various time-dependent regulatory processes have been identified originating from the suprachiasmatic nuclei (SCN), which convert external light information into synchronizing output signals. However, a direct impact of the SCN on the timing of normal food searching has not yet been found. Here, we revisited the function of the SCN to affect when mice look for food. We found that this process was independent of light but modified by the palatability of the food source. Surprisingly, reducing the output from the SCN, in particular from the vasopressin releasing neurons, reduced the amount of scavenging during the early activity phase. The SCN appeared to transmit a signal to the paraventricular nuclei (PVN) via GABA receptor A1. Finally, the interaction of SCN and PVN was verified by retrograde transport-mediated complementation. None of the genetic manipulations affected the uptake of more palatable food. The data indicate that the PVN are sufficient to produce blunted food searching rhythms and are responsive to hedonistic feeding. Nevertheless, the search for normal food during the early activity phase is significantly enhanced by the SCN.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice

et al. 2022

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“…It is well established that 5-HT and DA have a role in controlling food intake. [40] In anorexic animals, the hypothalamic ventromedial nucleus exhibits elevated 5-HT levels and reduced DA levels, along with increased levels of the dopaminergic receptors D1 and D2. [41] Therefore, the decreased weight of pups observed at PND 7, 14, and 21 may be due to changes in serotonergic and/or dopaminergic neurotransmission by VLZ and VOX exposure during prenatal brain development.…”

Section: Discussionmentioning

confidence: 99%

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2023

AJP

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Background: Vilazodone (VLZ) and Vortioxetine (VOX) are newer antidepressants often used for treating major depressive disorder, but potential therapeutic safety for brain development in pregnant women is almost negligible due to paucity of clinical and non-clinical data. Objectives: The current work was planned to investigate possible linkages between neurodevelopmental delay and prenatal exposure to equivalent therapeutic doses of VLZ and VOX. Materials and Methods: Pregnant Wistar rats were orally gavaged with VLZ and VOX (1 mg/kg, and 2 mg/kg body weight [BW]) from gestation day 6 to 21. The dams delivered naturally and reared their litters until postnatal day 21 during which neurodevelopment reflexes were recorded. Results: Prenatally VLZ-and VOX-exposed rats showed significant (1) reduction in BW, (2) delay in forelimb grasping, (3) delay in the day of apparition of cliff avoidance, (4) delay in response in negative geotaxis only in VOX group, (5) deficit in grip strength, and (6) delayed eye opening. Conclusion: Our findings suggest that early life exposure to VLZ and VOX might be involved in the retardation and maturation of some reflexes which imply an existing association between early life VLZ and VOX exposure with an increased risk of developmental vulnerability.

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“…While dopamine signaling is mostly recognized as a regulator of hedonic feeding, dopaminergic neurons are also located across the hypothalamus, suggesting that they may be directly involved in homeostatic feeding regulation ( Baik, 2021 ). Known as the A12 group, dopaminergic neurons located in the Arc were reported to promote feeding by inhibiting Arc POMC neurons via GABAergic synapses, and PVN via both DA and GABAergic synapses ( Zhang and van den Pol, 2016 ).…”

Section: Food As a Zeitgebermentioning

confidence: 99%

Dopamine systems and biological rhythms: Let’s get a move on

Tang

Assali

Güler

et al. 2022

Front. Integr. Neurosci.

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How dopamine signaling regulates biological rhythms is an area of emerging interest. Here we review experiments focused on delineating dopamine signaling in the suprachiasmatic nucleus, nucleus accumbens, and dorsal striatum to mediate a range of biological rhythms including photoentrainment, activity cycles, rest phase eating of palatable food, diet-induced obesity, and food anticipatory activity. Enthusiasm for causal roles for dopamine in the regulation of circadian rhythms, particularly those associated with food and other rewarding events, is warranted. However, determining that there is rhythmic gene expression in dopamine neurons and target structures does not mean that they are bona fide circadian pacemakers. Given that dopamine has such a profound role in promoting voluntary movements, interpretation of circadian phenotypes associated with locomotor activity must be differentiated at the molecular and behavioral levels. Here we review our current understanding of dopamine signaling in relation to biological rhythms and suggest future experiments that are aimed at teasing apart the roles of dopamine subpopulations and dopamine receptor expressing neurons in causally mediating biological rhythms, particularly in relation to feeding, reward, and activity.

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Dopaminergic Control of the Feeding Circuit

Cited by 26 publications

References 75 publications

Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice

Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice

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Dopamine systems and biological rhythms: Let’s get a move on

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