Dopaminergic innervation and modulation of hippocampal networks

Edelmann, Elke; Leßmann, Volkmar

doi:10.1007/s00441-018-2800-7

Cited by 75 publications

(68 citation statements)

References 224 publications

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“…This review focuses on the mechanisms by which the neuromodulators acetylcholine, dopamine, noradrenaline and serotonin modulate long-term synaptic plasticity in the hippocampus, highlighting common and divergent themes. For more in-depth reviews on the action of each individual neuromodulator on synaptic plasticity please see [ 7 , 8 , 9 , 10 ]. We propose that all the neuromodulators facilitate long-term synaptic plasticity often via common mechanisms but with differences potentially reflecting distinct aspects of uncertainty encoded by each neuromodulator.…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation of hippocampal long-term synaptic plasticity

Palacios-Filardo

Mellor

2019

Current Opinion in Neurobiology

145

105

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Multiple neuromodulators including acetylcholine, noradrenaline, dopamine and serotonin are released in response to uncertainty to focus attention on events where the predicted outcome does not match observed reality. In these situations, internal representations need to be updated, a process that requires long-term synaptic plasticity. Through a variety of common and divergent mechanisms, it is recently shown that all these neuromodulators facilitate the induction and/or expression of long-term synaptic plasticity within the hippocampus. Under physiological conditions, this may be critical for suprathreshold induction of plasticity endowing neuromodulators with a gating function and providing a mechanism by which neuromodulators enable the targeted updating of memory with relevant information to improve the accuracy of future predictions.

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Section: Introductionmentioning

confidence: 99%

Neuromodulation of hippocampal long-term synaptic plasticity

Palacios-Filardo

Mellor

2019

Current Opinion in Neurobiology

145

105

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“…Several origins of hippocampus-projecting dopaminergic fibers and a differential innervation along the hippocampal longitudinal axis have been described. Especially dopaminergic fibers arising from the ventral tegmental area and the substantia nigra pars compacta have been suggested to target the ventral hippocampal sector (reviewed in Edelmann and Lessmann, 2018). Notably, systemic NMDAR application can boost dopamine release in many brain regions (Deutch et al, 1987;Whitton et al, 1992;Breier et al, 1998).…”

Section: Dopamine-dependent Long-term Potentiation At Hippocampal Outmentioning

confidence: 99%

Noncanonical, Dopamine-Dependent Long-Term Potentiation at Hippocampal Output Synapses in a Rodent Model of First-Episode Psychosis

Bartsch

Behr

2020

Front. Mol. Neurosci.

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Cognitive deficits and positive symptoms in schizophrenia have both been linked to hippocampal dysfunction. Recently, subregion-specific aberrant and maladaptive hippocampal synaptic plasticity has been suggested as one of the mechanistic underpinnings. The subiculum is the final output hub of the hippocampus and orchestrates hippocampal information transfer to other brain regions. While most CA1 pyramidal neurons show regular-spiking behavior, subicular output neurons comprise bursting and regular-firing pyramidal cells. These two cell types target different brain regions and express unique forms of synaptic plasticity. Here, we used a single systemic application of the noncompetitive glutamatergic N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 to model first-episode psychosis in rats and studied long-term potentiation (LTP) in subicular regular-firing cells in acute hippocampal slices. Previously, we have reported a facilitation of a presynaptic, late-onset LTP in subicular bursting pyramidal cells after systemic NMDAR antagonism. Here, we show that single systemic NMDAR antagonist application also facilitates the induction of a noncanonical, but postsynaptic NMDAR-independent LTP in ventral subicular but not in CA1 regular-firing pyramidal cells. This form of LTP was dependent on D1/D5 dopamine receptor activation. Activation of D1/D5 dopamine receptors by a specific agonist mimicked and occluded LTP induced by electrical high-frequency stimulation (HFS). Furthermore, our results indicate that this form of LTP relies on postsynaptic Ca 2+ signaling and requires the activation of protein kinase A. Considering the pivotal role of the subiculum as information gatekeeper between the hippocampus and other brain regions, this aberrant LTP in ventral subicular regular-firing neurons is expected to interfere with physiological hippocampal output processing and might thereby contribute to hippocampal dysfunction in psychotic events.

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“…One of the possible mechanisms by which dopamine regulates learning and memory in the hippocampus is long term potentiation (LTP). It is an activitydependent modification of synaptic plasticity resulting in the long-lasting potentiation of synaptic transmission [21]. A step-through passive avoidance task is employed in studies on learning and memory in rats that is based on the fear of electric foot shock.…”

Section: Effects Of Tolcapone On Tests For Rigidity Bradykinesia Andmentioning

confidence: 99%

Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

Bakova

Zlatanova

Doncheva

et al. 2019

JAMMR

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Aim: The aim of the present study was to evaluate the effects of tolcapone in haloperidolchallenged rodent models of learning and memory and reserpine-induced parkinsonism in rats. Methods: The learning and memory enhancing effects of tolcapone (TCP) were assessed in male Wistar rats treated with 5, 15 and 30 mg/kg bw, p.o. The impact of tolcapone on haloperidol challenge and reserpine induced parkinsonism was studied in rodents treated with 5,15 and 30 mg/kg bw TCP p.o. Step-through passive avoidance and loco-motor activity were assessed. The latency reaction time and the number of horizontal and vertical movements were registered, respectively. Statistical analysis was done by SPSS Statistics 19.

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Dopaminergic innervation and modulation of hippocampal networks

Cited by 75 publications

References 224 publications

Neuromodulation of hippocampal long-term synaptic plasticity

Neuromodulation of hippocampal long-term synaptic plasticity

Noncanonical, Dopamine-Dependent Long-Term Potentiation at Hippocampal Output Synapses in a Rodent Model of First-Episode Psychosis

Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

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