Dopaminergic input is required for increases in serotonin output produced by behavioral activation: an in vivo microdialysis study in rat forebrain

Mendlin, Anna; Martín, Francisco Javier Escalada San; Jacobs, Barry L.

doi:10.1016/s0306-4522(99)00213-4

Cited by 55 publications

(30 citation statements)

References 55 publications

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“…Our study also revealed a relationship between decreased serotonergic activity measured by LDAEP and decreased dopamine transporter level (as measured by 123 I-FP-CIT SPECT) which points to an interaction between the serotonergic and the dopaminergic systems with the possibility of a " facilitatory role " of dopamine (Mendlin et al 1999). While there might also be a serotonergic dysfunction in untreated Parkinson's disease on its own, the possibility of an interaction between the dopaminergic and the serotonergic system has to be discussed.…”

Section: Resultsmentioning

confidence: 77%

See 1 more Smart Citation

Serotonergic neurotransmission in early Parkinson's disease: A pilot study to assess implications for depression in this disorder

Beucke

Uhl²,

Plotkin

et al. 2010

The World Journal of Biological Psychiatry

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Section: Resultsmentioning

confidence: 77%

“…Thus, a " facilitatory role " of dopamine on serotonergic function is suggested, since dopaminergic transmission is correlated with increased serotonergic neurotransmission (Mendlin et al 1999).…”

Section: Patients and Controlsmentioning

confidence: 99%

Serotonergic neurotransmission in early Parkinson's disease: A pilot study to assess implications for depression in this disorder

Beucke

Uhl²,

Plotkin

et al. 2010

The World Journal of Biological Psychiatry

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“…These mechanisms include the interplay of monoamine oxidase, vesicular monoamine transporters, the DA transporter, and possibly also the 5-HT transporter (Homan and Ziance, 1981;Seiden et al, 1993;Jones et al, 1998a). In addition, interactions between DAergic and serotonergic pathways may be responsible for an increase of extracellular 5-HT and a concomitant decrease of extracellular 5-HIAA after AMPH injection (Kuczenski and Segal, 1989;Mendlin et al, 1999). Altogether, the neurochemical data provided by the present study corroborate the existence of functionally very similar mesotelencephalic systems in birds and mammals, i.e., two vertebrate classes that phylogenetically separated more than 200 million years ago (Bock, 1967).…”

Section: Effects Of Amphmentioning

confidence: 97%

“…The greater extent of 5-HIAA decrease in NCL compared with LPO dialysates hints at a different regulation of serotonin release in these two structures possibly due to different functional properties of regulatory mechanisms at serotonergic terminals (Raiteri et al, 1975;Homan and Ziance, 1981). Additionally, it is also possible that transmitter release at serotonergic terminals in NCL and LPO is differentially regulated by DAergic pathways on which AMPH exerts its main effects (Kuczenski and Segal, 1989;Mendlin et al, 1999).…”

Section: Effects Of Amphmentioning

confidence: 98%

Functional aspects of dopamine metabolism in the putative prefrontal cortex analogue and striatum of pigeons (Columba livia)

Bast

Diekamp

Thiel

et al. 2002

J of Comparative Neurology

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Dopamine (DA) in mammalian associative structures, such as the prefrontal cortex (PFC), plays a prominent role in learning and memory processes, and its homeostasis differs from that of DA in the striatum, a sensorimotor region. The neostriatum caudolaterale (NCL) of birds resembles the mammalian PFC according to connectional, electrophysiological, and behavioral data. In the present study, DA regulation in the associative NCL and the striatal lobus parolfactorius (LPO) of pigeons was compared to uncover possible differences corresponding to those between mammalian PFC and striatum. Extracellular levels of DA and its metabolites (homovanillic acid [HVA], dihydroxyphenylacetic acid [DOPAC]) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were investigated by in vivo microdialysis of urethane-anesthetized pigeons under basal conditions and after systemic administration of D-amphetamine. DA was reliably determined only in LPO dialysates, and DA metabolite levels were significantly higher in LPO than in NCL. The HVA/DOPAC ratio, indicating extracellular lifetime of DA, was more than twice as high in NCL than in LPO dialysates. After amphetamine, DA increased in LPO while still being undetectable in NCL, and DA metabolites decreased in both regions. 5-HIAA slightly decreased in NCL dialysates. Amphetamine effects were delayed in NCL compared with the striatum. In conclusion, effects of amphetamine on the pigeon's ascending monoamine systems resemble those found in mammals, suggesting similar regulatory properties. The neurochemical differences between NCL and LPO parallel those between associative regions, such as PFC and dorsal striatum in mammals. They may reflect weaker regulation of extracellular DA, favoring DAergic volume transmission, in associative than striatal forebrain regions.

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“…Consistently, striatal 5-HT levels and 5-HTT binding have been reported to be increased in this animal model of PD (Commins et al, 1989;Zhou et al, 1991;Guerra et al, 1997;Mendlin et al, 1999;Balcioglu et al, 2003). Interestingly, it has been proposed that striatal 'reactive' serotonergic hyperinnervation in lesioned animals occurs to compensate for the lost function of DAergic terminals and this might 'mask' the true extent of the 5-HT loss in PD.…”

Section: -Ht Receptors' Expression In Pd Animal Models and In Patientsmentioning

confidence: 50%

Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

Matteo

Pierucci

Esposito

et al. 2008

Progress in Brain Research

138

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Several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. These observations are supported by anatomical evidence demonstrating large serotonergic innervation of all the basal ganglia nuclei. In fact, serotonergic terminals have been reported to make synaptic contacts with both substantia nigra dopamine-containing neurons and their terminal areas such as the striatum, the globus pallidus and the subthalamus. These brain areas contain a high concentration of serotonin (5-HT), with the substantia nigra pars reticulata receiving the greatest input. In this chapter, the distribution of different 5-HT receptor subtypes in the basal ganglia nuclei will be described. Furthermore, evidence demonstrating the serotonergic control of basal ganglia activity will be reviewed and the contribution of the different 5-HT receptor subtypes examined. The new avenues that the increasing knowledge of 5-HT in motor control has opened for exploring the pathophysiology and pharmacology of Parkinson's disease and other movement disorders will be discussed. It is clear that these avenues will be fruitful, despite the disappointing results so far obtained by clinical studies with selective 5-HT ligands. Nevertheless, these studies have led to a great increase in the attention given to the neurotransmitters of the basal ganglia and their connections.

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Dopaminergic input is required for increases in serotonin output produced by behavioral activation: an in vivo microdialysis study in rat forebrain

Cited by 55 publications

References 55 publications

Serotonergic neurotransmission in early Parkinson's disease: A pilot study to assess implications for depression in this disorder

Serotonergic neurotransmission in early Parkinson's disease: A pilot study to assess implications for depression in this disorder

Functional aspects of dopamine metabolism in the putative prefrontal cortex analogue and striatum of pigeons (Columba livia)

Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

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