Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

Ayon-Olivas, Maurilyn; Wolf, Daniel; Andreska, Thomas; Granado, Noelia; Lüningschrör, Patrick; Ip, Chi Wang; Moratalla, Rosario; Sendtner, Michael

doi:10.3390/biology12101360

Cited by 4 publications

(3 citation statements)

References 98 publications

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“…CREB forms a positive feedback loop with BDNF/TrkB signaling and enhances each other’s signaling. 67 …”

Section: Acupuncturementioning

confidence: 99%

“…CREB forms a positive feedback loop with BDNF/TrkB signaling and enhances each other's signaling. 67 The hippocampus, as part of the limbic nervous system, is involved in the development and rehabilitation of depression. Previous studies 68 found severe neuronal damage and abnormal cell structure in the CA1 region of the hippocampus in PSD rats.…”

Section: Improving Neuroplasticitymentioning

confidence: 99%

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Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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Depression is a prevalent mental disorder and has a profound impact on an individual’s psychological and physical well-being. It is characterized by a persistently depressed mood, loss of interest, energy loss, and cognitive dysfunction. In recent years, more and more people have changed to mental diseases, such as depression, anxiety, mania and so on. In the incidence of depression, covering all ages, but still mainly young and middle-aged women. Traditional treatments for depression mainly rely on medication and psychotherapy, but these methods are not effective for all patients and are often accompanied by certain side effects. Therefore, finding safe and effective alternative or adjuvant treatments has become a priority. Here we highlight the research progress of acupuncture in the treatment of depression and to explore the mechanism of acupuncture in the treatment of depression. Acupuncture treatment of depression is an ancient and effective method, the mechanism involves multiple biological pathways, for example, by regulating neurotransmitter levels, regulating the neuroendocrine axis, improving neuroplasticity, anti-inflammatory and other effects, improving emotional state and play an antidepressant role. To provide evidence to support the widespread use of acupuncture in clinical practice. We hope to provide new treatment ideas and methods for patients with depression, and even reduce the incidence of depression.

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“…CREB forms a positive feedback loop with BDNF/TrkB signaling and enhances each other’s signaling. 67 …”

Section: Acupuncturementioning

confidence: 99%

Section: Improving Neuroplasticitymentioning

confidence: 99%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

View full text Add to dashboard Cite

show abstract

“…This, in turn, exerts cytoprotective effects on dopaminergic neurons in the basal ganglia [ 28 , 29 ] and other areas of the brain including the bed nucleus of the stria terminalis, septum, cerebellum (nucleus of solitary tract), dentate gyrus of the hippocampus, and cerebral cortex [ 30 , 31 , 32 , 33 , 34 ]. BDNF regulates the amount of dopamine and dopaminergic cell activity in the striatum [ 35 ], and, in turn, dopaminergic input regulates the sensitivity of striatal spiny neurons to BDNF [ 36 ]. People with PD exhibit decreased levels of BDNF in the nigrostriatal pathway, compared to neurotypical age-matched controls [ 37 , 38 ], which may leave the brain more vulnerable to degeneration [ 19 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Kaagman,

van Wegen,

Cignetti

et al. 2024

Brain Sciences

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Introduction: Exercise therapy may increase brain-derived neurotrophic factor (BDNF) levels and improve clinical outcomes in people living with Parkinson’s disease (PD). This systematic review was performed to investigate the effect of exercise therapy on BDNF levels and clinical outcomes in human PD and to discuss mechanisms proposed by authors. Method: A search on the literature was performed on PubMed up to December 2023 using the following key words: Parkinson’s disease AND exercise, exercise therapy, neurological rehabilitation AND brain-derived neurotrophic factor, brain-derived neurotrophic factor/blood, brain-derived neurotrophic factor/cerebrospinal fluid AND randomized clinical trial, intervention study. Only randomized clinical trials comparing an exercise intervention to treatment as usual, usual care (UC), sham intervention, or no intervention were included. Results: A meta-analysis of BDNF outcomes with pooled data from five trials (N = 216 participants) resulted in a significant standardized mean difference (SMD) of 1.20 [95% CI 0.53 to 1.87; Z = 3.52, p = 0.0004, I2 = 77%], favoring exercise using motorized treadmill, Speedflex machine, rowing machine, and non-specified exercise. Significant improvements were found in Unified Parkinson’s Disease Rating Scale (UPDRS), UPDRS-III, 6 Minute Walk Test (6MWT), and Berg Balance Scale (BBS). Methodological quality of trials was categorized as “good” in three trials, “fair” in one trial, and “poor” in one trial. Conclusion: Key results of this systematic review are that exercise therapy is effective in raising serum BDNF levels and seems effective in alleviating PD motor symptoms. Exercise therapy confers neuroplastic effects on Parkinson brain, mediated, in part, by BDNF.

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BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson’s Disease and Dystonia

Wolf,

Ayon-Olivas,

Sendtner

2024

Biomedicines

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Neurotrophins, particularly brain-derived neurotrophic factor (BDNF), act as key regulators of neuronal development, survival, and plasticity. BDNF is necessary for neuronal and functional maintenance in the striatum and the substantia nigra, both structures involved in the pathogenesis of Parkinson’s Disease (PD). Depletion of BDNF leads to striatal degeneration and defects in the dendritic arborization of striatal neurons. Activation of tropomyosin receptor kinase B (TrkB) by BDNF is necessary for the induction of long-term potentiation (LTP), a form of synaptic plasticity, in the hippocampus and striatum. PD is characterized by the degeneration of nigrostriatal neurons and altered striatal plasticity has been implicated in the pathophysiology of PD motor symptoms, leading to imbalances in the basal ganglia motor pathways. Given its essential role in promoting neuronal survival and meditating synaptic plasticity in the motor system, BDNF might have an important impact on the pathophysiology of neurodegenerative diseases, such as PD. In this review, we focus on the role of BDNF in corticostriatal plasticity in movement disorders, including PD and dystonia. We discuss the mechanisms of how dopaminergic input modulates BDNF/TrkB signaling at corticostriatal synapses and the involvement of these mechanisms in neuronal function and synaptic plasticity. Evidence for alterations of BDNF and TrkB in PD patients and animal models are reviewed, and the potential of BDNF to act as a therapeutic agent is highlighted. Advancing our understanding of these mechanisms could pave the way toward innovative therapeutic strategies aiming at restoring neuroplasticity and enhancing motor function in these diseases.

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Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor

Cited by 4 publications

References 98 publications

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis

BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson’s Disease and Dystonia

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