Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model

Salgueiro, Willian G.; Soares, Marcell Valandro; Martins, Cassiano Fiad; Paula, Fávero Reisdorfer; Rios-Anjos, Rafaela Maria; Carrazoni, Thiago; Mori, Marcelo A.; Aschner, Michael; Belo, Cháriston André Dal; Ávila, Daiana Silva

doi:10.1016/j.cbi.2023.110610

Chemico-Biological Interactions

2023

DOI: 10.1016/j.cbi.2023.110610

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Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model

Willian G. Salgueiro

Marcell Valandro Soares

Cassiano Fiad Martins

et al.

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2024

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Cited by 3 publications

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Potential use of quercetin in the reduction of craving in cocaine‐dependent patients—A pilot clinical trial

Nicolucci,

Rodrigues,

Marson

et al. 2024

Phytotherapy Research

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To the editor Cocaine is widely recognized as a highly addictive drug that can cause severe consequences for physical and mental health, and its damage to the neurovascular system, cognitive decline, and behavioral dysfunctions are well-documented (UNOCD, n.d.). Cocaine acts on the brain by inhibiting the reuptake of neurotransmitters, especially dopamine, resulting in a positive reinforcement, and a pleasant sensation that increases its consumption (Planeta et al., 2013). However, in high concentrations, dopamine is neurotoxic, causing neurodegeneration, and consequently, cell death (Ben-Shachar et al., 2004;Planeta et al., 2013). Craving for cocaine also changes dopamine neurotransmission due to the reduction of D 2 receptor expression (Martinez et al., 2004) and the condition can cause neuroadaptations by inhibiting GABA (Gamma-aminobutyric acid) release that, in turn, affects the dopaminergic system (Sofuoglu & Kosten, 2005). Moreover, modifications in the composition of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor subunits, enhancing the strength of excitatory synapses, characteristic of prolonged period of abstinence.

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Potential use of quercetin in the reduction of craving in cocaine‐dependent patients—A pilot clinical trial

Nicolucci,

Rodrigues,

Marson

et al. 2024

Phytotherapy Research

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Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans

Hu,

Zhu,

et al. 2024

Chemico-Biological Interactions

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Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans

Lei,

Hu,

Liu

2024

Chemosphere

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Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model

Cited by 3 publications

References 89 publications

Potential use of quercetin in the reduction of craving in cocaine‐dependent patients—A pilot clinical trial

Potential use of quercetin in the reduction of craving in cocaine‐dependent patients—A pilot clinical trial

Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans

Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans

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