Dopaminergic modulation of novelty repetition in Parkinson’s disease: A study of P3 event-related brain potentials

Abstract

Objective: Parkinson's Disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. Cognitive impairments have been reported using the event-related potential (ERP) technique. Patients show reduced novelty P3 (nP3) amplitudes in oddball experiments, a response to infrequent, surprising stimuli, linked to the orienting response of the brain. The nP3 is thought to depend on dopaminergic neuronal pathways though the effect of dopaminergic medication in PD has not yet been investigated.Methods: Twenty-two patients with PD were examined "on" and "off" their regular dopaminergic medication in a novelty 3-stimulus-oddball task. Thirty-four healthy controls were also examined over two sessions, but received no medication. P3 amplitudes were compared throughout experimental conditions.Results: All participants showed sizeable novelty difference ERP effects, i.e. ndP3 amplitudes, during both testing sessions. An interaction of diagnosis, medication and testing order was also found, indicating that dopaminergic medication modulated ndP3 in patients with PD across the two testing sessions: We observed enhanced ndP3 amplitudes from PD patients who were off medication on the second testing session. Conclusion:Patients with PD 'off' medication showed ERP evidence for repetition-related enhancement of novelty responses. Dopamine depletion in neuronal pathways that are affected by mid-stage PD possibly accounts for this modulation of novelty processing.Significance: The data in this study potentially suggest that repetition effects on novelty processing in patients with PD are enhanced by dopaminergic depletion. Highlights:(1)All participants showed robust novelty P3 waveforms during both testing sessions.(2) Patients who were tested on medication during a first session, showed enhanced novelty P3 amplitudes during a second session (off medication).(3) Our results demonstrate the necessity for properly controlled repeated-measures designs to isolate diagnosis or medication effects and novelty or repetition effects.

Parkinson's disease affects the neural alpha oscillations associated with speech‐in‐noise processing

“…Hence, the results of the present study cannot rule out an auditory gating deficit at lower stages of auditory processing, which may impair the ability to suppress irrelevant auditory information. In addition, alterations regarding the allocation of cognitive resources towards irrelevant but salient auditory information have also been described in PD, although electrophysiological findings on this matter have been largely inconsistent, ranging between significantly increased (e.g., Bertram et al, 2020;Cavanagh et al, 2018;Heldmann et al, 2019) towards decreased P3a amplitude in persons with PD compared with HCs (Pauletti et al, 2019;Solís-Vivanco et al, 2011. Moreover, persons with PD that were included in the present study demonstrated numerically higher Mismatch Negativity amplitudes compared with HCs (De Groote et al, 2021a).…”

“…Whereas generally no significant differences have been found regarding the Mismatch Negativity (Karayanidis et al, 1995;Solís-Vivanco et al, 2011Vieregge et al, 1994), rather inconsistent P3a alterations have been reported in persons with PD compared with HCs (for a review, see Seer et al, 2016). Commonly regarded as a neural correlate of bottom-up involuntary attention switching (Polich, 2007), P3a amplitude has been reported to be either decreased (Pauletti et al, 2019;Solís-Vivanco et al, 2011 or increased (Bertram et al, 2020;Cavanagh et al, 2018;Heldmann et al, 2019) in persons with PD compared with HCs, respectively, suggesting decreased or increased involuntary allocation of attention towards salient and potentially relevant information in the auditory environment in PD. Similar to AEPs, significantly less suppression of P3a amplitude over time has been observed in persons with PD (Cavanagh et al, 2018;Tsuchiya et al, 2000).…”

Pupil Dilation and the Slow Wave ERP Reflect Surprise about Choice Outcome Resulting from Intrinsic Variability in Decision Confidence

“…2007 ; Weinshenker and Schroeder 2007 ; Manohar and Husain 2015 ; Varazzani et al. 2015 ; Mathôt 2018 ), and although a link between dopamine and the P3 has also been observed in Parkinson’s patients, evidence is more mixed (see e.g., Bertram et al. 2020 ).…”

Electrophysiological Markers of Aberrant Cue-Specific Exploration in Hazardous Drinkers

“…pre-insertion trial) ( Figure 1b ). Prior research indicates that novel minus non-novel difference waves can be useful for distinguishing clinical populations ( Kappenman & Luck, 2016 ) and have been used to do so for assessing novelty-sensitive neural responses ( Bertram et al, 2020 ). To test whether each P3 component related to cue-specific explore-exploit behavior between groups, we ran two models predicting choice behavior from group and cue type, one with P3a amplitude and one with P3b amplitude as additional predictors.…”