Dopaminergic modulation of rat pup ultrasonic vocalizations

Dastur, Farhad N.; McGregor, Iain S.; Brown, Richard E.

doi:10.1016/s0014-2999(99)00590-7

Cited by 41 publications

(45 citation statements)

References 89 publications

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“…As in prior reports in which systemic quinpirole elevated behavioral activity level compared to vehicle infusion levels (Dastur et al, 1999), activity as measured by the combined activity score was increased by local infusion of quinpirole in either the nucleus accumbens or the dorsal striatum, paired-t(18) = 5.20, p < .001 and paired-t(14) = 5.02, p < .001, respectively (see Figure 6). Elevated activity level could not be the cause of disrupted potentiation because pups infused in either location showed increased activity, but only pups infused in the nucleus accumbens did not show potentiation of isolation vocalizations.…”

Section: Motor Effects Of D2 Receptor Stimulation Do Not Account For supporting

confidence: 71%

Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact.

Muller¹,

Moore²,

Myers³

et al. 2008

Behavioral Neuroscience

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Most mammalian infants vocalize when isolated. The vocalization promotes caregiver proximity, which is critical to survival. If, before isolation, a rat pup has contact with its dam, its isolation vocalization rate is increased (maternal potentiation) relative to isolation preceded only by littermate contact. Prior work showed that systemic administration of a D2 receptor agonist blocks maternal potentiation at doses that do not alter baseline vocalization. In this study, infusion of quinpirole (2 µg/side) into the nucleus accumbens also blocks maternal potentiation. Infusion of the accumbens with the D2 antagonist raclopride (4 µg/side) prevents systemic quinpirole from blocking potentiation. Quinpirole infusion in the dorsal striatum did not affect maternal potentiation and infusion of raclopride in the dorsal striatum did not reverse the block of maternal potentiation by systemic quinpirole. Vocalization results after a second vehicle infusion on a given day are no different than the results following an initial vehicle infusion, so experimental design can not account for the effects of drug infusions. Because activity level was increased by both dorsal and ventral striatum infusions, activity level can not account for the results.Keywords infant vocalization; social behavior; dopamine; D2; ventral striatum Mammalian infants' proximity maintaining behavior with caregivers is critical to their survival, and likely contributes the formation of social bonds (Bowlby, 1969;Francis, Diorio, Liu, & Meaney, 1999;Harlow, Dodsworth, & Harlow, 1965;Hofer, 1994). From birth until weaning, most infant mammals vocalize when socially isolated (Gurski, Davis, & Scott, 1980;Hennessy & Ritchey, 1987;Hofer, Brunelli, & Shair, 1993;Kalin, Shelton, & Snowdon, 1992;Rifkin & Glickman, 2004). Isolation-induced ultrasonic vocalizations (USV) of rat pups guide retrieval by the dam and elicit other maternal behaviors (Hashimoto, Saito, Furudate, & Takahashi, 2001;Jans & Leon, 1983).Brief interaction with a potential caregiver just before social isolation increases rate and intensity of vocalization, an effect termed "potentiation" Kraebel, Brasser, Campbell, Spear, & Spear, 2002;Myers et al., 2004 USV potentiation for investigation of mechanisms by which social bonds are formed lies in its social specificity and, in at least some forms, in its dependence on experience. For damreared pups, potentiated USV responses to isolation are elicited only by adult females; not by interactions with littermates, home cage bedding, or neutered adult males, even though all these stimuli reduce vocalization when they are placed with the isolated pup in the test chamber (Brunelli, Masmela, Shair, & Hofer, 1998;Hofer et al., 1994). Importantly, if pups have been reared with their sire, adult males can elicit USV potentiation (Brunelli et al., 1998;Shair, 2007).Dopamine has been implicated in social behaviors. Adult pair bonding (Wang et al., 1999) and maternal behavior (Stern & Lonstein, 2001) both depend on dopaminergic activity. Regarding inf...

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Section: Motor Effects Of D2 Receptor Stimulation Do Not Account For supporting

confidence: 71%

Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact.

Muller¹,

Moore²,

Myers³

et al. 2008

Behavioral Neuroscience

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“…A number of neurotransmitter systems are known to be capable of regulating isolation-induced USV by rat pups including GABA [51,81,86,119], opioid [4,20,57], serotonergic [53,117], cholinergic [13], corticotrophin-releasing hormone [34,50], vasopressinergic [114], and dopaminergic [27,58,59]. In most cases, it has not yet been determined whether the effects of exogenous administration of neuroactive ligands truly demonstrate roles for endogenous processes.…”

Section: Neurochemical Regulation Of the Expression Of Potentiationmentioning

confidence: 99%

Acquisition and expression of a socially mediated separation response

Shair¹

2007

Behavioural Brain Research

108

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INTRODUCTIONSocial bonds are made up of numerous subsystems mediating the overall social relationships that develop between infants and caretakers. The effects of an infant's formation of early life relationships and its social interactions with caretakers are known to last well in to adulthood with both beneficial and harmful effects [28,35,70]. In our laboratory, we study the development of social relationships between infant rats and their dams, sires, and littermates using an isolation, reunion, and re-isolation test paradigm.Infant rats emit ultrasonic vocalizations (USV) in a variety of situations, including as a response to isolation, physical manipulation, and thermal and olfactory challenge [1][2][3]6,19,25,46,79,80,82,97]. Many researchers have used the presence and absence of these sounds to make inferences about the internal state of the rodents, e.g., isolation-induced USV's have often been called "distress vocalizations" [29,76,78].The isolation-induced vocalization of a rat pup is modulated both by current social interactions and by the pup's rearing experience. This modulation of USV by social interactions provides a paradigm for investigating the neurobehavioral mechanisms underlying acquisition and expression of infant attachment. What is maternal potentiation of isolation-induced vocalizations of infant rats?Maternal potentiation of ultrasonic vocalization occurs when, after a brief contact with the dam, isolated infant rats produce USV at a rate significantly higher than they would during an isolation not preceded by dam contact. Although the definition may seem of narrow interest, there is a growing belief that the potentiation phenomenon has broad applicability for the study of early life social relationships in many species. But before going further, the reader needs to understand the usual test paradigm in our laboratory.Developmental Psychobiology, Unit 40, New York State Psychiatric Institute, 1051 Riverside Dr. NY, NY 100032, Tele 212-543-5695, Fax 212-543-5467, hns1@columbia.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptTest procedure-On the day of testing, the dam is removed from the home cage and anesthetized. The litter is allowed to adapt to her removal for ~15-20min in the home cage on a thermoregulated heating pad. Then, each pup is tested in turn. The pup is picked up and placed alone in a clean polycarbonate rectangular box (18 × 21 × 20 cm) at room temperature. The test consists of three periods, which can range from 1-5min in length (3mi...

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“…At one extreme, for example, ultrasonic calls are produced just hours after birth (Sales 1979;Dastur et al 1999), which indicates that the neural substrates have completed their development prenatally. At the opposite extreme, active avoidance does not appear before the end of the second postnatal week (Cuomo et al 1996).…”

Section: Behavioral Studiesmentioning

confidence: 99%