Dopaminergic Regulation of the Intermediate Pituitary

Millington, William R.; Chronwall, Bibie M.

doi:10.1007/978-1-4612-3554-5_1

Cited by 14 publications

(11 citation statements)

References 156 publications

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“…Notably, these cells are grouped in nests surrounded by TH-positive fibers (Fig. 6D) that originate from the periventricular hypothalamic nucleus, hereby forming the tuberohypophyseal dopaminergic system (Millington and Chronwall, 1989;Goudreau et al, 1995).…”

Section: Pituitarymentioning

confidence: 99%

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Kell

Dehghani

Wicht

et al. 2004

J of Comparative Neurology

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In morphogenetic dynamics of neurons, and in adaptive physiology of brain function, transcription factors of the cyclicAMP signaling pathway, such as activator cyclicAMP responsive element binding protein (CREB) and inhibitor inducible cyclicAMP early repressor (ICER), play an important role. In particular, the presence of the transcription factor ICER in neurons or neuroendocrine cells suggests the need for the gating of an up-regulated gene expression. Little is known, however, about the natural distribution of the inhibitory transcription factor ICER. We, therefore, mapped the rodent brain and pituitary for an ICER immunoreaction and found a nuclear staining for this transcription factor. ICER-positive glial cells were found throughout the brain. ICER-positive neurons were found in sensory input centers, like the olfactory bulb, or sensory brain stem nuclei, and in hypothalamic nuclei involved in central neuroendocrine control. In addition, neuroendocrine/endocrine transducers, like the pituitary and the pineal gland showed a high basal presence of ICER. Our data show that a basic ICER level is required by many cell systems and can be seen as an anticipatory and/or a protective measure in systems with superior reactive dynamics.

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Section: Pituitarymentioning

confidence: 99%

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Kell

Dehghani

Wicht

et al. 2004

J of Comparative Neurology

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“…The intermediate lobe is innervated by neurons con taining a variety of neurotransmitters including dopa mine, norepinephrine, 5-hydroxytryptamine, y-aminobutyric acid, and corticotropin-releasing hormone [3], The morphology of terminal arborizations identified in the present study resembles catecholamine-containing axons and varicosities originally described in the intermediate lobe [22,23]. Accordingly, the results of the present study indicate that neurons projecting from the periventricular nucleus to the intermediate lobe are catecholaminergic since the intermediate lobe fibers anterogradely labelled with PHA-L are also immunoreactive for TH, a marker for catecholamine-synthesizing cells [24], It is most likely that these TH-immunoreactive terminal arbors are DA since noreadrenergic nerve terminal arbors comprise only a small percentage of the catecholaminergic fibers found in the intermediate lobe [22,25,26] and the hypothalamic periventricular nucleus does not contain noradrenergic perikarya [27,28].…”

Section: Discussionmentioning

confidence: 99%

Periventricular-Hypophysial Dopaminergic Neurons Innervate the Intermediate but Not the Neural Lobe of the Rat Pituitary Gland

et al. 1995

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The purpose of the present study was to determine the relative distribution of axon terminals of A₁₄ periventricular-hypophysial dopaminergic (PHDA) neurons in the neural and intermediate lobes of the rat pituitary gland. Discrete unilateral injections of the anterograde tracer Phaseolusvulgaris leucoagglutinin (PHA-L) into the periventricular nucleus resulted in labelling of extensively branched terminal axonal arbors in the intermediate lobe, but not the neural lobe of the pituitary gland. In contrast, unilateral injections of PHA-L into the paraventricular nucleus revealed thick, varicose terminal arborizations containing PHA-L in the neural lobe, but not the intermediate lobe. Terminal axonal branches and varicosities containing PHA-L immunoreactivity in the intermediate lobe were also immunoreactive for tyrosine hydroxylase. These results reveal that A₁₄ PHDA neurons originating in the periventricular nucleus of the hypothalamus project axons to the intermediate lobe of the rat pituitary gland.

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“…Other receptors are also expressed. Thus, the cells serve as an in vivo and in vitro model system to study several receptors and secretion‐related activities (Millington and Chronwall 1989). Because of the difficulties associated with harvesting and maintaining large quantities of primary melanotropes, an effort was made to identify a clonal cell line that constitutively expresses functional GABA B receptors that could be used to study their composition, regulation and expression.…”

mentioning

confidence: 99%

Constitutive expression of functional GABA_Breceptors in mIL‐tsA58 cells requires both GABA_B(1)and GABA_B(2)genes

Chronwall

Davis

Severidt

et al. 2001

Journal of Neurochemistry

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Studies of g-aminobutyric acid (GABA) B receptor function in heterologous cell systems have suggested that expression of two distinct seven transmembrane G-protein coupled receptor subunits is necessary for receptor activation and signal transduction. Some results suggest that both receptor proteins must be inserted into the plasma membrane to create heterodimers; however, it is possible that subunit monomers or homodimers are functional in cells which constitutively express GABA B receptors. A new pituitary intermediate lobe melanotrope cell clone (mIL tsA58) has been isolated which constitutively expresses GABA B , D 2 and corticotrophin releasing factor receptors. Here, we report on characterization of the GABA B receptors. Solution hybridization-nuclease protection assays reveal the presence of GABA B(1) and GABA B(2) transcripts. Western blots show GABA B(1a) and one of two GABA B (2)

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Dopaminergic Regulation of the Intermediate Pituitary

Cited by 14 publications

References 156 publications

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Periventricular-Hypophysial Dopaminergic Neurons Innervate the Intermediate but Not the Neural Lobe of the Rat Pituitary Gland

Constitutive expression of functional GABA_Breceptors in mIL‐tsA58 cells requires both GABA_B(1)and GABA_B(2)genes

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Dopaminergic Regulation of the Intermediate Pituitary

Cited by 14 publications

References 156 publications

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary

Periventricular-Hypophysial Dopaminergic Neurons Innervate the Intermediate but Not the Neural Lobe of the Rat Pituitary Gland

Constitutive expression of functional GABABreceptors in mIL‐tsA58 cells requires both GABAB(1)and GABAB(2)genes

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Constitutive expression of functional GABA_Breceptors in mIL‐tsA58 cells requires both GABA_B(1)and GABA_B(2)genes