Dopaminergic transmission in the hypothalamic arcuate nucleus to produce acupuncture analgesia in correlation with the pituitary gland

Takeshige, Chifuyu; Tsuchiya, Mayumi; Guo, Shiyu; Sato, Takao

doi:10.1016/0361-9230(91)90195-p

Cited by 32 publications

(16 citation statements)

References 21 publications

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“…All of these areas have been involved in acupuncture analgesia. Using combined lesion techniques and evoked potentials, Takeshige et al (20)(21)(22)(23)(24) reported that the dorsal periaqueductal gray (PAG) arcuate nucleus, lateral and posterior hypothalamus, lateral septum, dorsal hippocampus, habenula-interpeduncular tract, central medial nucleus of the thalamus and anterior hypothalamus are involved in acupuncture analgesia. Studies with mapping of neuronal activity using c-Fos immunohistochemistry in unanesthetized animals have shown that both 2 and 100 Hz EA can up-regulate c-Fos expression in several regions of the brain, including the lateral habenula, PVH, arcuate nucleus, PAG and gigantocellular nucleus (25,26).…”

Section: Specific Effect Of Stimulation At Point 36smentioning

confidence: 99%

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

Medeiros

Canteras

Suchecki

et al. 2003

Braz J Med Biol Res

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In laboratory animals, acupuncture needs to be performed on either anesthetized or, if unanesthetized, restrained subjects. Both procedures up-regulate c-Fos expression in several areas of the central nervous system, representing therefore a major pitfall for the assessment of c-Fos expression induced by electroacupuncture. Thus, in order to reduce the effect of acute restraint we used a protocol of repeated restraint for the assessment of the brain areas activated by electroacupuncture in adult male Wistar rats weighing 180-230 g. Repeated immobilization protocols (6 days, 1 h/day and 13 days, 2 h/ day) were used to reduce the effect of acute immobilization stress on the c-Fos expression induced by electroacupuncture at the Zusanli point (EA36S). Animals submitted to immobilization alone or to electroacupuncture (100 Hz, 2-4 V, faradic wave) in a non-point region were compared to animals submitted to electroacupuncture at EA36S (4 animals/subgroup). c-Fos expression was measured in 41 brain areas by simple counting of cells and the results are reported as number of c-Fos-immunoreactive cells/10,000 µm 2 . The protocols of repeated immobilization significantly reduced the immobilizationinduced c-Fos expression in most of the brain areas analyzed (P < 0.05). Animals of the EA36S groups had significantly higher levels of c-Fos expression in the dorsal raphe nucleus, locus coeruleus, posterior hypothalamus and central medial nucleus of the thalamus. Furthermore, the repeated immobilization protocols intensified the differences between the effects of 36S and non-point stimulation in the dorsal raphe nucleus (P < 0.05). These data suggest that high levels of stress can interact with and mask the evaluation of specific effects of acupuncture in unanesthetized animals.

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Section: Specific Effect Of Stimulation At Point 36smentioning

confidence: 99%

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

Medeiros

Canteras

Suchecki

et al. 2003

Braz J Med Biol Res

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“…1c. Synaptic connections between acupuncture afferent and efferent pathways [25,28] The final region of the acupuncture afferent pathway is found in the M-HARN, which is anatomically close to the P-HARN, the initial region of the acupuncture efferent pathway (Fig. 3).…”

Section: Introductionmentioning

confidence: 98%

“…the preoptic area (POA) or the median eminence (ME), abolish AA. Electrical potentials are evoked in these brain areas by stimulation of acupoints, but stimulation of these particular brain structures does not produce analgesia [25,28] (Fig. 1, 2 and 5).…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of Acupuncture Analgesia Produced by Low - Frequency Electrical Stimulation of Acupuncture Points

Takeshige¹

2002

Dt Ztschr f Akup

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“…These pathways involve many neurotransmitters, including serotonin, endogenous opiates, and norepinephrine [3]. Electroacupuncture has stronger effects than other types of acupuncture [4], and acupuncture analgesia has been produced using different types of stimulations at both acupoints and nonacupuncture points [5]. Acupuncture has been proven to be effective for treating pain, geriatric diseases, and exercise-related diseases in horses [6], and results of neuroscience studies have provided a physiological basis for explaining how acupuncture works and how it stimulates the release of painkillers known as endorphins [7].…”

Section: Introductionmentioning

confidence: 99%

Successful Practice of Electroacupuncture Analgesia in Equine Surgery

Sheta

Ragab

Farghali

et al. 2015

Journal of Acupuncture and Meridian Studies

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Electroacupuncture analgesia was used for surgery in horses and donkeys. A KWD-808 electrical stimulator was used to incrementally induce a dense, dispersed wave output at frequencies from 20 to 55 Hz, which was maintained at a frequency of 55 Hz, and to change the amplitude of the wave to the best grading number for the suggested operation in each animal. Induction of analgesia lasted for 20-30 minutes, and the effect of analgesia was maintained for 20-45 minutes depending on the type of surgery performed. The exhibited clinical signs, physical examination data, and the responses of all animals were used for evaluating the periods of analgesia. Although the majority of the cases (95%) had no response to strong surgical pain, they experienced significant increases in heart rates and respiratory rates during induction. The lack of pain, relaxed surgical procedures, reduced intraoperative bleeding, and improved healing without complications were all definite benefits of using electroacupuncture analgesia in surgery. Thus, this study has provided surgical evidence supporting the effectiveness of electroacupuncture analgesia, as well as confirming its reliability, in the field of equine anesthesia and surgery.

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Dopaminergic transmission in the hypothalamic arcuate nucleus to produce acupuncture analgesia in correlation with the pituitary gland

Cited by 32 publications

References 21 publications

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization

Mechanisms of Acupuncture Analgesia Produced by Low - Frequency Electrical Stimulation of Acupuncture Points

Successful Practice of Electroacupuncture Analgesia in Equine Surgery

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