Dopant for detection of methamphetamine in the presence of nicotine with ion mobility spectrometry

Ultra-Fast Polarity Switching, Non-Radioactive Drift Tube for the Miniaturization of Drift-Time Ion Mobility Spectrometer

“…Spectrum data of narcotic and explosive samples from Section 3.2.2 was used to calculate the reduced mobility, which was summarized in Tables 1 and 2. As shown in Tables 1 and 2, majority of the analytes tested demonstrated good consistency of measured K 0 to that reported in the literature, with HMTD as the only exception for reasons to be further investigated [31][32][33][34][35].This result, the successful mobility correction of both polarities using a single calibrator with only positively charged product ion, proves the feasibility of not only to reduce a drift tube from the system, but also to eliminate the need for the second calibrator with associated container and supporting accessories, which is a substantial step for further miniaturization of the DT-IMS instrument. The underlying reason can be ascribed to the stable and consistent drift field of both working mode.…”

In-Line Dopant Generation for Atmospheric Pressure Ionization Mass Spectrometry

“…Like commercial permeation systems which calibrate for each trace gas, further gravimetric permeation rate measurements with other solvents can confirm the universality of permeation response. In addition to temperature and gas flow rate control, the permeation rate was lowered by reducing the membrane area exposure, which might be useful for applications that use low dopant concentrations . As the dimensionality of the polymer membrane is the only factor limiting the functionality, the design might be reproduced in various sizes for various analytical applications, even increasing the permeation rate by reducing the membrane thickness.…”

Interpol Review of Drug Analysis 2019-2022

“…2019 Analysis of aerosolized methylamphetamine from e-cigarettes using SPME-DART-HRMS and SPME-GC-MS [ 162 ]; fluorescent nanosensor for detection of methylamphetamine [ 163 ]; supercritical fluid chromatography-tandem mass spectrometry method could be a powerful analytical tool for methylamphetamine impurity profiling [ 164 ]; 2020 a novel fluorescent nanosensor based on graphene quantum dots embedded within molecularly imprinted polymer was developed for detection and determination of methylamphetamine [ 165 ]; chemosensor for detection of MA [ 166 ]; determination of the stereoisomeric distribution of R-(−)- and S-(+)-MA using HPLC-MS and GC-MS [ 167 ]; use of IRMS alongside conventional chemical profiling techniques to investigate whether methylamphetamine samples of differing P2P origins can be distinguished through drug profiling [ 168 ]; smartphone-based device for rapid on-site MA detection [ 169 ]; fluorescent drug detection device based on LED induction (FD-LED) for MA [ 170 ]; NIR-PLS quantitative modelfor seven adulterants with MA purity ranging from 10% to 100%, [ 171 ]; fluorescent nanosensor for detection of MA [ 172 ]; 2021 fluorescence resonance energy transfer-thermal lens spectrometry (FRET-TLS) for the determination of MA [ 173 ]; H-1 NMR method for discrimination of the enantiomers of MA from ephedrine and pseudoephedrine using chiral solvents [ 174 ]; review of the optical and electrochemical sensors used to date for MA detection in seized and biological samples [ 175 ]; development of an IMS method to detect MA using pyridine as a dopant in the presence of nicotine [ 176 ]; development and validation of a modified LC-ESI-MS/MS method for the simultaneous determination of MA and its isomer N-isopropylbenzylamine (N-IBA) in forensic samples [ 177 ]; SERS method for detection of MA [ 178 , 179 ]; investigation of the reaction mechanisms of three different synthesis methods (Nagai, Hypo, and Moscow) for MA [ 180 ]; establishment of likelihood ration models to evaluate the cause of MA contamination resulting from either use or clandestine manufacturing [ 181 ]; 2022 study of forensic markers of 1-phenyl-2-propanone synthetic pathways for identification of precoursors to methamphetamine [ 182 ]; impurity profiling of MA synthesized from alpha-phenylacetoacetonitrile (APAAN) including the identification of five new impurities and two previously identified impurities [ 183 ]; investigation of the use of stable isotope ratio mass spectrometry (IRMS) to determine the precursor and precursor origin of MA drug samples [ 184 ]; development of an electrochemical detection technique to determine the residual methamphetamine contamination on household surfaces [ 1...…”