Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices

Weisman, Jeffery A.; Jammalamadaka, Udayabhanu; Tappa, Karthik; Mills, David K.

doi:10.3390/bioengineering4040096

Cited by 33 publications

(25 citation statements)

References 78 publications

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“…In medicine, FDM is used for fabricating customized patient-specific medical devices, such as implants, prostheses, anatomical models, and surgical guides. Various thermoplastic polymers are doped with variety of bioactive agents, including antibiotics [ 10 ], chemotherapeutics [ 11 ], hormones [ 12 ], nanoparticles [ 13 , 14 ], and other oral dosages [ 15 , 16 ] for personalized medicine. Using this technology, non-biocompatible materials, such as ABS [ 17 ] or thermoplastic polyurethane (TPU), are used for creating medical models for perioperative surgical planning and simulations [ 18 ].…”

Section: Commonly Used 3d Printing Technologies In the Medical Fiementioning

confidence: 99%

Novel Biomaterials Used in Medical 3D Printing Techniques

Tappa

Jammalamadaka

2018

JFB

Self Cite

377

213

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The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and pharmaceutical fields. A vast variety of biomaterials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. With continuous research and progress in biomaterials used in 3D printing, there has been a rapid growth in applications of 3D printing in manufacturing customized implants, prostheses, drug delivery devices, and 3D scaffolds for tissue engineering and regenerative medicine. The current review focuses on the novel biomaterials used in variety of 3D printing technologies for clinical applications. Most common types of medical 3D printing technologies, including fused deposition modeling, extrusion based bioprinting, inkjet, and polyjet printing techniques, their clinical applications, different types of biomaterials currently used by researchers, and key limitations are discussed in detail.

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Section: Commonly Used 3d Printing Technologies In the Medical Fiementioning

confidence: 99%

Novel Biomaterials Used in Medical 3D Printing Techniques

Tappa

Jammalamadaka

2018

JFB

Self Cite

377

213

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“…Moreover, the tensile strength and adhesion to bone of the composite was significantly increased. Recently, 3D printing drug‐doped halloysite with polylactic acid was used to fabricate antimicrobial devices for bone regeneration . The loaded gentamicin was released in a sustained manner from these systems and exhibited an excellent antibacterial inhibition.…”

Section: Bone Regeneration Bioscaffold Cell Coating and Labelingmentioning

confidence: 99%

Tubule Nanoclay‐Organic Heterostructures for Biomedical Applications

Liu

Fakhrullin

Новиков

et al. 2018

Macromolecular Bioscience

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Natural halloysite nanotubes (HNTs) show unique hollow structure, high aspect ratio and adsorption ability, good biocompatibility, and low toxicity, which allow for various biomedical applications in the diagnosis and treatment of diseases. Here, advances in self‐assembly of halloysite for cell capturing and bacterial proliferation, coating on biological surfaces and related drug delivery, bone regeneration, bioscaffolds, and cell labeling are summarized. The in vivo toxicity of these clay nanotubes is discussed. Halloysite allows for 10–20% drug loading and can extend the delivery time to 10–100 h. These drug‐loaded nanotubes are doped into the polymer scaffolds to release the loaded drugs. The rough surfaces fabricated by self‐assembly of the clay nanotubes enhance the interactions with tumor cells, and the cell capture efficacy is significantly improved. Since halloysite has no toxicity toward microorganisms, the bacteria composed within these nanotubes can be explored in oil/water emulsion for petroleum spilling bioremediation. Coating of living cells with halloysite can control the cell growth and is not harmful to their viability. Quantum dots immobilized on halloysite were employed for cell labeling and imaging. The concluding academic results combined with the abundant availability of these natural nanotubes promise halloysite applications in personal healthcare and environmental remediation.

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“…In current 3D printing applications, there are a range of material limitations, ranging from heat resistance to strength. The addition of clay nanoparticles, such has halloysite, could be used to modify polymer material properties and so improve adhesion, tensile, compressive, thermal, and other properties [39]. Finally, the use of HNTs as a nanocontainer to incorporate drugs or bioactive factors, singly or in multiples, provides a significant capability to 3D printed polymer-based devices [39,40].…”

Section: Discussionmentioning

confidence: 99%

The Use of 3D Printing in the Fabrication of Nasal Stents

et al. 2017

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Nasoalveolar molding of the cleft lip, nose, and alveolar palate has been a successful strategy for the restoration of oronasal function and appearance, but it has some drawbacks. The temporary implant that is inserted before surgical reconstruction is a large appliance requiring numerous adjustments, it can irritate delicate soft tissues, and interfere with the infant's ability to nurse or feed. In the early post-operative period and for months after cleft lip repair, patients wear standardized silicone stents that come in multiple sizes, but require significant sculpting to fit the unique cleft deformity. Three-dimensional (3D) printing offers the potential of highly personalized and patient-specific treatment. We developed a method that produces a customized 3D printed stent that matches the contours and unique features of each patient and permits modification and adjustments in size and shape as the patient ages. With 3D scanning technology, the device can be designed at the first visit to create an appliance that can be worn sequentially with minimal trauma, does not impede feeding, and a prosthesis that will improve compliance. The device will be worn intraorally to help shape the alveolus, lip, and nose before surgical repair. Furthermore, the stent can be doped with drugs as each patient's case warrants.

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Doped Halloysite Nanotubes for Use in the 3D Printing of Medical Devices

Cited by 33 publications

References 78 publications

Novel Biomaterials Used in Medical 3D Printing Techniques

Novel Biomaterials Used in Medical 3D Printing Techniques

Tubule Nanoclay‐Organic Heterostructures for Biomedical Applications

The Use of 3D Printing in the Fabrication of Nasal Stents

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