2012
DOI: 10.2174/138527212804546840
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Doped Keggin Heteropolyacids as Catalyst in the Solvent-free, Multicomponent Synthesis of Substituted 3,4-dihydropyrimidin-2-(1H)-ones

Abstract: We report the use of V, Bi and Bi-V Keggin structure where Mo is partially replaced by V, Bi, and Bi and V, respectively, in the solvent-free multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by the Biginelli method. The incorporation of V, Bi and Bi-V in the structure of PMo notably increases the catalytic activity. The following correlation between the yields of the 3,4-dihydropyrimidin-2-(1H)-ones and the number of acidic sites of the catalysts was observed: PMoBiV > PMoV > PMoBi > PMo. The react… Show more

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Cited by 22 publications
(11 citation statements)
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“…In previous work, we found that the incorporation of V in the structure of PMo increases the number of acidic sites. In this sense, a correlation between the yields and the number of acidic sites was observed [14]. Here, V incorporation slightly increases the reaction yields.…”
Section: Catalytic Test and Suitable Synthesis Of Nifedipinementioning
confidence: 64%
See 1 more Smart Citation
“…In previous work, we found that the incorporation of V in the structure of PMo increases the number of acidic sites. In this sense, a correlation between the yields and the number of acidic sites was observed [14]. Here, V incorporation slightly increases the reaction yields.…”
Section: Catalytic Test and Suitable Synthesis Of Nifedipinementioning
confidence: 64%
“…HPAs possess a very strong acidity, which can be changed by varying the chemical composition of the primary structure of the heteropolyanion. As part of a research project to develop eco-efficient organic transformation, especially multicomponent reactions, we used different bulk, supported and included heteropolyacids in the preparation of heterocyclic synthesis, under greener conditions, such as the synthesis of functionalized pyridine [13], substituted 3,4-dihydropyrimidin-2-(1H)-ones [14], 14-aryl-14H-dibenzo[a, j]xanthenes [15], highly substituted hexahydropyrimidines [16], and ferrocenyl-pyrimidones [17].…”
Section: Introductionmentioning
confidence: 99%
“…The ionic liquids caused a positive effect because the yield of the reaction increased, and the synthesis time decreased. The optimal reaction conditions were: 1 mmol of each reagent, catalyst: 28% SiW 12 /Y (50 mg), ionic liquid: 1-n-butyl-3-methylimidazolium hexafluorophosphate (BMI•PF 6 , 0.5 mL), and 100 • C for 1 h. D'alessandro et al [36] reported a similar procedure for the synthesis of dihydropyrimidinones. In this work, molybdophosphoric acid was modified by partially exchanging molybdenum atoms for vanadium, bismuth, or vanadium-bismuth atoms (PMo 11 V, PMo 11 Bi, and PMo 10 VBi) and the resulting acids were tested in the Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions.…”
Section: Pyrimidinesmentioning
confidence: 99%
“…Heteropolyacids (HPAs) are well defined molecular clusters that are remarkable for their molecular and electronic structural diversity and their significance is quite diverse in many areas, e.g., catalysis, medicine, and materials science [20,21]. HPAs are complex proton acid that incorporate polyoxometalate anions (heteropolyanions) having metal-oxygen octahedra as the basic structural units and catalysis by them is a field of increasing importance [22][23][24][25][26][27][28][29][30]. Heteropolyacids as solid acid catalysts are green with respect to corrosiveness, safety, quantity of waste, and separ ability and it is well known that the use of heteropolyacid catalysts for organic synthesis reactions can give a lot of benefits.…”
Section: 24-triazolomentioning
confidence: 99%