Doppler-Derived Mitral Deceleration Time

Cerisano, Giampaolo; Bolognese, Leonardo; Carrabba, Nazario; Buonamici, Piergiovanni; Santoro, Giovanni Maria; Antoniucci, David; Santini, Alberto; Moschi, Guia; Fazzini, Pier Filippo

doi:10.1161/01.cir.99.2.230

Cited by 117 publications

(36 citation statements)

References 28 publications

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“…11,12 Multiple factors may contribute to LV remodeling at different stages, from the time of coronary occlusion until the development of ventricular dilation and dysfunction. Infarct size, 13 anterior infarct location, 14 transmural extent of necrosis, 9 perfusional status of the IRA, 15 heart failure on admission, 16 and restrictive pattern of LV filling 17,18 have been identified as major predictors of LV dilatation after myocardial infarction in various patient populations. The importance of microvascular dysfunction by MCE complicating mechanical reperfusion after AMI as an additional major predictor of early LV remodeling has been suggested by recent studies.…”

Section: Microvascular Dysfunction and LV Remodelingmentioning

confidence: 99%

Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction

et al. 2004

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Background-We hypothesized that preserved microvascular integrity in the area at risk would favorably influence left ventricular (LV) remodeling and long-term outcome after acute myocardial infarction. Methods and Results-Before and after successful primary angioplasty (percutaneous transluminal coronary angioplasty[PTCA]), 124 patients with acute myocardial infarction underwent intracoronary myocardial contrast echo (MCE). An MCE score index (MCESI) was derived by averaging the single-segment score (0ϭnot visible, 1ϭpatchy, 2ϭhomo-geneous contrast effect) within the area at risk. An MCESI Ն1 was considered adequate reperfusion. Mean follow-up was 46Ϯ32 months. After PTCA, 100 patients showed adequate reperfusion (no microvascular dysfunction, NoMD), whereas 24 did not (MD

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Section: Microvascular Dysfunction and LV Remodelingmentioning

confidence: 99%

Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction

et al. 2004

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“…To evaluate diastolic function, the E and A wave and the E-wave deceleration time (DT) were measured from the mitral inflow Doppler echocardiograms. LV restrictive filling pattern was recognized in the presence of DT Յ130 ms. 14 …”

Section: Echocardiographic Examinationmentioning

confidence: 99%

“…24 However, LV remodeling, as defined in the current report, has been shown to be of prognostic value. [13][14][15] Finally, we did not evaluate the impact of vascular remodeling and function on long-term clinical status. As is well known, arterial load influences systolic and diastolic LV performance, and clinical studies indicate that arterial stiffness may be increased in diastolic HF.…”

Section: Study Limitationsmentioning

confidence: 99%

Heart Failure and Left Ventricular Remodeling After Reperfused Acute Myocardial Infarction in Patients With Hypertension

et al. 2006

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Abstract-In the thrombolytic era, hypertension has been shown to adversely affect the development of heart failure after acute myocardial infarction (AMI). We sought to examine the relation between antecedent hypertension and heart failure after mechanical reperfusion and to test the impact of postinfarction left ventricular remodeling on heart failure in hypertensive patients. A series of 953 patients (324 hypertensives) with AMI treated with successful primary percutaneous coronary intervention underwent a 5-year follow-up. A subgroup of 325 subjects underwent 2D echocardiography at admission, 1 month, and 6 months. From day 1 to 6 months, despite similar improvement in regional and global left ventricular function and similar 6-month infarct artery patency rate, left ventricular end-diastolic volume increased in the normotensives (122Ϯ36 mL to 131Ϯ47 mL; PϽ0.001) but not in the hypertensives (127Ϯ41 mL to 128Ϯ31 mL; Pϭ0.768). At 6 months, the incidence of left ventricular remodeling in hypertensive and normotensive patients was not different (22% versus 28%; Pϭ0.210). However, at 5 years, the incidences of hospitalization for heart failure (7% versus 3%; Pϭ0.014) and of New York Heart Association functional class Ն2 (53% versus 40%; PϽ0.001) were higher in hypertensive as compared with normotensive patients. Hypertension was found to be a predictor of heart failure (hazard ratio, 2.23; Pϭ0.015). In conclusion, patients with antecedent hypertension are at higher risk to develop heart failure after AMI, even when successfully reperfused by primary percutaneous coronary intervention. However, the increased incidence of heart failure in hypertensive patients is not associated with a greater propensity to postinfarction left ventricular remodeling. Key Words: heart failure Ⅲ hypertrophy Ⅲ remodeling Ⅲ coronary artery disease Ⅲ myocardial infarction H ypertension is a well-known risk factor for coronary artery disease and heart failure. It has been shown that after thrombolysis for acute myocardial infarction (AMI), antecedent hypertension increases the risk of heart failure (HF) and other adverse events. [1][2][3][4][5] The progression to HF after AMI is mainly related to left ventricular (LV) remodeling. 6 However, animal 7,8 and human studies 5,9,10 evaluating the relation between hypertension and early LV remodeling after AMI have yielded conflicting or inconclusive results.Several studies have demonstrated that mechanical reperfusion (primary percutaneous coronary intervention, PCI) is superior to pharmacological reperfusion (thrombolysis), because it allows brisk and sustained flow achievement in the infarct-related artery (IRA) in a higher proportion of patients with subsequent improved myocardial salvage and better long-term outcome. 11 Thus, in the last decade, an increasing number of centers have adopted primary PCI as the preferred reperfusion therapy for AMI.In this study, we sought to examine the relation between antecedent hypertension and the development of HF after successful primary PCI for AMI. An...

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“…6 LV systolic dysfunction was defined as an echocardiographic LVEF p40%. 16 A restrictive LV filling pattern was defined as a Doppler mitral E wave deceleration time (DT) p130 ms. 17 Coronary restenosis was defined as a X50% diameter stenosis of the infarct-related artery at follow-up angiogram.…”

Section: Definitions and Outcome Measuresmentioning

confidence: 99%

Time course of serum collagen types I and III metabolism products after reperfused acute myocardial infarction in patients with and without systemic hypertension

et al. 2008

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We examined 55 consecutive patients successfully treated with primary percutaneous coronary intervention (PCI) for a first acute myocardial infarction with left ventricular (LV) systolic dysfunction. In all patients we performed echocardiographic examination, dosage of plasma brain natriuretic peptide, serum carboxy-terminal propeptide and telopeptide of procollagen type I and amino-terminal propeptide of procollagen type III at days 1 and 3, and at 1 and 6 months after index infarction. The hypertensive patients (group 1; n ¼ 30) differed for higher baseline blood pressure (133±4 mm Hg vs 118±4 mm Hg; P ¼ 0.03), greater LV mass index (108 ± 5 vs 94 ± 4 g m À2 , P ¼ 0.03) and lower mitral E/A wave peak (0.8 ± 0.06 vs 1.1±0.12, P ¼ 0.02) with respect to non-hypertensive patients (group 2; n ¼ 25). From day 1 to month 6 carboxy-terminal propeptide of procollagen type I and amino-terminal propeptide of procollagen type III increased (Po0.005 and Po0.05, respectively) in both groups, whereas carboxy-terminal telopeptide of procollagen type I increased from day 1 to day 3 (Po0.01 in both groups, respectively) and then decreased from day 3 to month 6 (Po0.01 and Po0.05 in both groups, respectively). From day 1, brain natriuretic peptide decreased in both groups (Po0.005). There was no significant difference between the two groups in values of procollagens and natriuretic peptide. Finally, LV diastolic volume and function at 6 months were similar in the two groups. Thus, in patients with reperfused acute myocardial infarction and LV dysfunction, antecedent hypertension was not associated with a different pattern of serum procollagen release and ventricular remodelling at 6 months of follow-up.

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Doppler-Derived Mitral Deceleration Time

Cited by 117 publications

References 28 publications

Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction

Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction

Heart Failure and Left Ventricular Remodeling After Reperfused Acute Myocardial Infarction in Patients With Hypertension

Time course of serum collagen types I and III metabolism products after reperfused acute myocardial infarction in patients with and without systemic hypertension

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