Doppler Embolic Signals in Cerebrovascular Disease and Prediction of Stroke Risk

King, A. J.; Markus, Hugh S.

doi:10.1161/strokeaha.109.563056

Cited by 182 publications

(129 citation statements)

References 76 publications

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“…TCD is relatively cheap, can be performed bedside, and allows monitoring both in acute emergency settings as well as for prolonged periods with a high temporal resolution making it ideal for studying dynamic cerebrovascular responses. Also, systolic upstroke, velocity, pulsatility index and direction of flow could be reliable measured by using TCD (King and Markus 2009;Yeo and Sharma 2010).In the present study we wanted to test whether cerebral blood flow velocity is altered in patients with SCF and for this aim, middle cerebral artery flow velocity was measured in patients with SCF and compared those with normal coronary flow by using TCD. …”

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Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Karakaya

Koçer

Esen

et al. 2011

Tohoku J. Exp. Med.

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Slow coronary flow (SCF) is characterized by delayed opacification of coronary arteries during coronary angiography and is associated with myocardial perfusion abnormalities, ischemia or myocardial infarction. We hypothesized that SCF could be a part of systemic circulatory abnormalities. Therefore, the present study was conducted to investigate whether cerebral blood flow velocity is altered in patients with SCF. The study included 16 patients suffering from chest pain with angiographically proven SCF and 16 subjects suffering from atypical chest pain with angiographically normal coronary flow. All study subjects were selected among those who undergone routine cardiac catheterization. SCF was defined based on thrombolysis in myocardial infarction frame count that reflects coronary artery flow. Thrombolysis in myocardial infarction frame count was significantly higher in patients with SCF than those with normal coronary flow. The average peak systolic, end diastolic and mean flow velocities of the middle cerebral artery were measured and recorded in both groups by transcranial Doppler ultrasonography. Baseline demographic properties were similar in both groups. Echocardiographic parameters were also similar in patients with SCF and those with normal coronary flow. In contrast, both right and left middle cerebral artery peak systolic, end diastolic and mean flow velocities were significantly lower in patients with SCF than those with normal coronary flow. We conclude that cerebral blood flow velocity is significantly lower in patients with SCF. SCF phenomenon may reflect a part of impaired systemic circulation.Keywords: cerebral blood flow; coronary angiography; slow coronary flow; thrombolysis in myocardial infarction frame count; transcranial Doppler Tohoku J. Exp. Med., 2011, 225 (1), 13-16. © 2011 Tohoku University Medical Press Slow coronary flow (SCF), characterized by slow antegrade progression of dye in the absence of obstructive coronary disease, has been noted in the coronary arteries during routine angiographic study, but its precise mechanism has not been well documented. SCF was first defined by Tambe at al. (1972) on six patients with chest pain. However, the exact etiology, pathogenesis and long term outcome of SCF patients is still unknown although endothelial, vasomotor and microvascular dysfunction and occlusive disease of small coronary arteries were suggested in its etiology (Moserri et al. 1986;Mangieri et al. 1996;Sezgin et al. 2003). It is also unknown whether SCF phenomenon is a disorder limited to the coronary artery or it involves cerebral circulation as well.Transcranial Doppler ultrasonography (TCD) is a noninvasive method that provides reliable information about the hemodynamic status of the cerebral circulation. TCD is relatively cheap, can be performed bedside, and allows monitoring both in acute emergency settings as well as for prolonged periods with a high temporal resolution making it ideal for studying dynamic cerebrovascular responses. Also, systolic upstroke, velocity, pulsat...

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Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Karakaya

Koçer

Esen

et al. 2011

Tohoku J. Exp. Med.

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“…44 (50). Albeit frequency of MES was 24% in average in this meta-analysis, heterogeneity among studies included is again significant.…”

Section: Acute Strokementioning

confidence: 65%

Neurosonology of emboli detection and monitoring

Topçuoğlu¹,

Arsava²

2012

Türk Beyin Damar Hast Derg

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Cerebral embolism is the leading cause of ischemic stroke. Detection of microembolic signals [MES] in cerebral circulation is uniquely attained by several transcranial Doppler techniques, and can not be obtained with any other available imaging modality. Albeit no uniform picture has emerged from the studies, presence and amount of MES can identify a high-risk status in the setting of potential arterial or cardiac sources of cerebral embolism. Real-time MES monitoring during vascular procedures with high cerebral embolism risk seems also promising. The potential of MES detection in improvement of patient care is usually acknowledged, even though several aspects remain yet to be scientifically established. We herein review theory, technique and clinical potential of the neurosonological emboli detection, and try to add to understanding of the journal readership about the recent development on this subject.

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“…Вважають, що близько 95 % випадків ТІА зумовлені макроангіопатіямі, мікроангіопатіями -ураженням внутрішньочерепних судин малого калібру або карді-альною емболією [20][21][22][23][24].…”

Section: провідні патогенетичні механізми тіаunclassified

Патогенез Транзиторных Ишемических Атак: Проблема Подтипов

Vinychuk¹,

Fartushna²

2022

INJ

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Doppler Embolic Signals in Cerebrovascular Disease and Prediction of Stroke Risk

Cited by 182 publications

References 76 publications

Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Neurosonology of emboli detection and monitoring

Патогенез Транзиторных Ишемических Атак: Проблема Подтипов

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