Doppler Ultrasonographic Findings on Hepatic Arterial Vasospasm Early After Liver Transplantation

Chen, Wei; Facciuto, Marcelo; Rocca, Juan P.; Marvin, Michael R.; Sheiner, Patricia A.; Rachlin, Susan; Rodriguez, Manuel I.

doi:10.7863/jum.2006.25.5.631

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…Diastolic reversal of flow has been reported after liver transplantation, in cases of arterial vasospasm, early after the procedure. 3 In the carotid arteries, this finding is described in cases of high-grade stenosis or occlusion of the internal carotid artery. 4 Similar findings have been reported in intracranial vasospasm secondary to subarachnoid hemorrhage.…”

Section: Discussionmentioning

confidence: 98%

Reversal of Diastolic Blood Flow in the Testis of a Patient With Impending Infarction Due to Epididymitis

Gerscovich

Bateni

Kazemaini

et al. 2008

Journal of Ultrasound in Medicine

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Section: Discussionmentioning

confidence: 98%

Reversal of Diastolic Blood Flow in the Testis of a Patient With Impending Infarction Due to Epididymitis

Gerscovich

Bateni

Kazemaini

et al. 2008

Journal of Ultrasound in Medicine

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“…Second, peak levels of CRP (Figure S1), an established parameter of inflammation and surgical trauma, were significantly lower following alprostadil therapy. And furthermore, higher peak values of arterial RI (Figure S1) demonstrated impaired graft perfusion in the non‐PGE1 group …”

Section: Discussionmentioning

confidence: 99%

Treating ischaemia‐reperfusion injury with prostaglandin E1 reduces the risk of early hepatocellular carcinoma recurrence following liver transplantation

Kornberg

Witt

Kornberg

et al. 2015

Aliment Pharmacol Ther

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“…An RI above 0.8 but below 1 was given a score of 1. A RI <0.5 together with a SAT below 0.08 s resulted in a 2, whereas a score of 3 was allocated in the case of hepatic arterial occlusion (if a surgical problem was excluded: RI <0.5 together with a SAT ≥0.08 s [23], vasospasm indicated by a RI ≥1 [24], and clinical judgment).…”

Section: Methodsmentioning

confidence: 99%

Treatment-emergent adverse events after infusion of adherent stem cells: the MiSOT-I score for solid organ transplantation

Dillmann

Popp

Fillenberg

et al. 2012

Trials

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BackgroundCellular therapy after organ transplantation is emerging as an intriguing strategy to achieve dose reduction of classical immunosuppressive pharmacotherapy. Here, we introduce a new scoring system to assess treatment-emergent adverse events (TEAEs) of adherent stem cell therapies in the clinical setting of allogeneic liver transplantation (for example, the MiSOT-I trial Eudract CT: 2009-017795-25).MethodsThe score consists of three independent modalities (set of parameters) that focus on clinically relevant events early after intravenous or intraportal stem cell infusion: pulmonary toxicity, intraportal-infusional toxicity and systemic toxicity. For each modality, values between 0 (no TEAE) and 3 (severe TEAE) were defined. The score was validated retrospectively on a cohort of n=187 recipients of liver allografts not receiving investigational cell therapy between July 2004 and December 2010. These patients represent a control population for further trials. Score values were calculated for days 1, 4, and 10 after liver transplantation.ResultsGrade 3 events were most commonly related to the pulmonary system (3.5% of study cohort on day 4). Almost no systemic-related TEAEs were observed during the study period. The relative frequency of grade 3 events never exceeded 5% over all modalities and time points. A subgroup analysis for grade 3 patients provided no descriptors associated with severe TEAEs.ConclusionThe MiSOT-I score provides an assessment tool to score specific adverse events that may occur after adherent stem cell therapy in the clinical setting of organ transplantation and is thus a helpful tool to conduct a safety study.

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Doppler Ultrasonographic Findings on Hepatic Arterial Vasospasm Early After Liver Transplantation

Abstract: High-resistance hepatic arterial flow (resistive index = 1) early after liver transplantation is indicative of hepatic arterial vasospasm if it responds to vasodilators. Doppler ultrasonography is a useful tool for the diagnosis of this vascular complication.

Cited by 23 publications

References 23 publications

Reversal of Diastolic Blood Flow in the Testis of a Patient With Impending Infarction Due to Epididymitis

Reversal of Diastolic Blood Flow in the Testis of a Patient With Impending Infarction Due to Epididymitis

Treating ischaemia‐reperfusion injury with prostaglandin E1 reduces the risk of early hepatocellular carcinoma recurrence following liver transplantation

Treatment-emergent adverse events after infusion of adherent stem cells: the MiSOT-I score for solid organ transplantation

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