Doppler ultrasonographic studies of the vascular resistance of the uterine artery in the mare associated with vasoactive and antikoagulative theory

Abstract

ZusammenfassungBei sieben Stuten, deren Endometrium im modifizierten Beurteilungsschema nach Kenney und Doig (Schoon et al., 1992) In seven mares with endometrial biopsies graded either I or IIA (Schoon et al., 1992) the resistance of the uterine artery wall was measured by Doppler sonography to investigate the influence of the vasoactive substances isoxsuprine, acepromacine, heparin and phenprocoumon. Isoxsuprine and acepromacine are known to act directly at the vessel wall. In the present study could be demonstrated that these substances cause an increase in the wall resistance compared to basic values. These investigations were carried out on six mares on two successive days during diestrus. In 4 mares treated with a low-dose-regimen of heparin (Gerhards und Eberhardt, 1988) on four days during diestrus the wall resistance decreased compared to corresponding values of untreated cycles as well as to basic values at the onset of the treatment period. One mare was treated with phenprocoumone for two cycles. The dosis was chosen according to the results of daily performed coagulating blood tests. The resistance decreased gradually before ovulation compared to untreated cycles. The use of anticoagulating substances seems promissing in the therapy of pathological uterine blood flow.