Doppler ultrasound measurements of renal functional reserve in healthy subjects

doi:10.11152/mu.2013.2066.174.dop

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…In addition to these, the resistive index (RI) was calculated. The RI value is the ratio of the difference between the PSV and the EDV divided by PSV value: RI=(PSV–EDV)/PSV, and provides information about arterial impedance [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Decreased Vertebral Artery Hemodynamics in Patients with Loss of Cervical Lordosis

et al. 2016

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BackgroundBecause loss of cervical lordosis leads to disrupted biomechanics, the natural lordotic curvature is considered to be an ideal posture for the cervical spine. The vertebral arteries proceed in the transverse foramen of each cervical vertebra. Considering that the vertebral arteries travel in close anatomical relationship to the cervical spine, we speculated that the loss of cervical lordosis may affect vertebral artery hemodynamics. The aim of this study was to compare the vertebral artery values between subjects with and without loss of cervical lordosis.Material/MethodsThirty patients with loss of cervical lordosis and 30 controls matched for age, sex, and body mass index were included in the study. Sixty vertebral arteries in patients with loss of cervical lordosis and 60 in controls without loss of cervical lordosis were evaluated by Doppler ultrasonography. Vertebral artery hemodynamics, including lumen diameter, flow volume, peak systolic velocity, end-diastolic velocity, and resistive index, were measured, and determined values were statistically compared between the patient and the control groups.ResultsThe means of diameter (p=0.003), flow volume (p=0.002), and peak systolic velocity (p=0.014) in patients were significantly lower as compared to controls. However, there was no significant difference between the 2 groups in terms of the end-diastolic velocity (p=0.276) and resistive index (p=0.536) parameters.ConclusionsThe present study revealed a significant association between loss of cervical lordosis and decreased vertebral artery hemodynamics, including diameter, flow volume, and peak systolic velocity. Further studies are required to confirm these findings and to investigate their possible clinical implications.

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Section: Methodsmentioning

confidence: 99%

Decreased Vertebral Artery Hemodynamics in Patients with Loss of Cervical Lordosis

et al. 2016

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“…This test, performed in 18 healthy volunteers, seems to be very easy and accurate with no clinical risks for the patients. Moreover, Pekkafal and Kara proposed the incorporation of a Doppler resistive index (RI) and pulsatility index (PI) into the assessment of RFR [ 138 ]. The RFR assessment should be of particular utility in specific clinical situations (such as determining the status of the kidneys in potential living kidney donors; preparatory evaluation/counseling, etc.)…”

Section: Tools For Aki Predicion and Severity Diagnosismentioning

confidence: 99%

Predicting acute kidney injury: current status and future challenges

2017

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Acute kidney injury (AKI) is characterized by an acute decline in renal function and is associated to increased mortality rate, hospitalization time, and total health-related costs. The severity of this ‘fearsome’ clinical complication might depend on, or even be worsened by, the late detection of AKI, when the diagnosis is based on the elevation of serum creatinine (SCr). For these reasons, in recent years a great number of new tools, biomarkers and predictive models have been proposed to clinicians in order to improve diagnosis and prevent the development of AKI. The purpose of this narrative paper is to review the current state of the art in prediction and early detection of AKI and outline future challenges.

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Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival?

Moor

Vanwalleghem

Swennen

et al. 2018

Clinical Kidney Journal

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Renal stimulation tests document the dynamic response of the glomerular filtration rate (GFR) after a single or a combination of stimuli, such as an intravenous infusion of dopamine or amino acids or an oral protein meal. The increment of the GFR above the unstimulated state has formerly been called the renal functional reserve (RFR). Although the concept of a renal reserve capacity has not withstood scientific scrutiny, the literature documenting renal stimulation merits renewed interest. An absent or a blunted response of the GFR after a stimulus indicates lost or diseased nephrons. This information is valuable in preventing, diagnosing and prognosticating acute kidney injury and pregnancy-related renal events as well as chronic kidney disease. However, before renal function testing is universally practiced, some shortcomings must be addressed. First, a common nomenclature should be decided upon. The expression of RFR should be replaced by renal functional response. Second, a simple protocol must be developed and propagated. Third, we suggest designing prospective studies linking a defective stimulatory response to emergence of renal injury biomarkers, to histological or morphological renal abnormalities and to adverse renal outcomes in different renal syndromes.

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Doppler ultrasound measurements of renal functional reserve in healthy subjects

Cited by 4 publications

References 21 publications

Decreased Vertebral Artery Hemodynamics in Patients with Loss of Cervical Lordosis

Decreased Vertebral Artery Hemodynamics in Patients with Loss of Cervical Lordosis

Predicting acute kidney injury: current status and future challenges

Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival?

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