Dopplerographic Time-Interval T(E-Ea) in Evaluation of Left Ventricular Diastolic Function in Children with Acute Lymphoblast Leucosis During Polychemotherapy

Changes in the Cardiovascular System in Patients with Acute Leukemia after the Use of Polychemotherapy

“…Chronic cardiotoxicity in the form of dilated cardiomyopathy is reported in 4.5-7.0% of patients, usually at the end of the course of treatment or shortly after its completion. In recent years, the possibility of later development of this complication has been reported [3]. A severe course of doxirubicin-induced cardiomyopathy was described, which developed 15 years after children were cured of cancer, while there were no signs of heart damage in the immediate period after treatment.…”

“…In children with ALL at different stages of polychemotherapy, various clinical symptoms (arterial dystonia, cardialgia, functional systolic murmur, etc.) and electrocardiographic signs of cardiovascular disorders were identified, characterized at the onset of the disease by nomotopic disorders of automaticity, recorded in 21.0% of cases by the predominance of process disorders repolarization in the LV myocardium during therapy and after its completion in 63.0% and 48.0% of cases, respectively [3].…”