2024
DOI: 10.1186/s12935-024-03278-5
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Dormancy of cutaneous melanoma

Kathrin Singvogel,
Birgit Schittek

Abstract: Many cancer-related deaths including melanoma result from metastases that develop months or years after the initial cancer therapy. Even the most effective drugs and immune therapies rarely eradicate all tumor cells. Instead, they strongly reduce cancer burden, permitting dormant cancer cells to persist in niches, where they establish a cellular homeostasis with their host without causing clinical symptoms. Dormant cancers respond poorly to most drugs and therapies since they do not proliferate and hide in nic… Show more

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Cited by 3 publications
(2 citation statements)
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“…Unfortunately, many such tumors recur with reduced treatment susceptibility, even after initially effective interventions. Such recurrence often leads to the death of the patient and has been explained by the dormancy of malignant cells that initially survived the cytotoxic treatment ( 1 ). The mechanisms governing entry into and emergence from dormancy remain inadequately understood ( 1 ).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Unfortunately, many such tumors recur with reduced treatment susceptibility, even after initially effective interventions. Such recurrence often leads to the death of the patient and has been explained by the dormancy of malignant cells that initially survived the cytotoxic treatment ( 1 ). The mechanisms governing entry into and emergence from dormancy remain inadequately understood ( 1 ).…”
Section: Introductionmentioning
confidence: 99%
“…Such recurrence often leads to the death of the patient and has been explained by the dormancy of malignant cells that initially survived the cytotoxic treatment ( 1 ). The mechanisms governing entry into and emergence from dormancy remain inadequately understood ( 1 ). The present review aims to elucidate this phenomenon with a particular emphasis on the cells of origin of cancers.…”
Section: Introductionmentioning
confidence: 99%