Dormant Tumors Awaken by a Short-Term Angiogenic Burst: The Spike Hypothesis

Indraccolo, Stefano; Favaro, Elena; Amadori, Alberto

doi:10.4161/cc.5.16.2985

Cited by 45 publications

(37 citation statements)

References 40 publications

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“…Experimental data suggest a link between bursts in angiogenesis and breaks in dormancy in sarcoma and other cancer models. (35) The causes for such bursts or the clinical scenarios that may be linked to these events are not understood.…”

Section: Etiology Of Osteosarcomamentioning

confidence: 99%

Osteosarcoma

Görlick

Khanna

2010

Journal of Bone and Mineral Research

154

126

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It has been difficult to identify the molecular features central to the pathogenesis of osteosarcoma owing to a lack of understanding of the cell or origin, the absence of identifiable precursor lesions, and its marked genetic complexity at the time of presentation. Interestingly, several human genetic disorders and familial cancer syndromes, such as Li-Fraumeni syndrome, are linked to an increased risk of osteosarcoma. Association of these same genetic alterations and osteosarcoma risk have been confirmed in murine models. Osteosarcoma is associated with a variety of genetic abnormalities that are among the most commonly observed in human cancer; it remains unclear, however, what events initiate and are necessary to form osteosarcoma. The availability of new resources for studying osteosarcoma and newer research methodologies offer an opportunity and promise to answer these currently unanswered questions. Even in the absence of a more fundamental understanding of osteosarcoma, association studies and preclinical drug testing may yield clinically relevant information. ß

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Section: Etiology Of Osteosarcomamentioning

confidence: 99%

Osteosarcoma

Görlick

Khanna

2010

Journal of Bone and Mineral Research

154

126

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“…Indraccolo et al 14 provide novel insight as to the requirement for high levels of angiogenic factors to interrupt dormancy and subsequently low or moderate levels to maintain a functional vasculature in the now growing tumors. Marches et al 13 describe how in a model of B-cell lymphoma, immunizing toward the BCL1 Ig idiotype can induce tumor dormancy.…”

Section: Two Potential Mechanisms For Tumor Dormancy: What Can We Leamentioning

confidence: 99%

The Problem of Cancer Dormancy: Understanding the Basic Mechanisms and Identifying Therapeutic Opportunities

Aguirre‐Ghiso¹

2006

Cell Cycle

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“…Tumour growth beyond the size of 1-2 mm is angiogenesis-dependent. Therefore, it was hypothesized that the angiogenic spike induced by MSCs or ADSCs could awake dormant cancer cells (Naumov et al, 2006;Vessella et al, 2007;Indraccolo et al, 2006;Favaro et al, 2008); but more recent studies (Donnenberg et al, 2010;Zimmerlin et al, 2011) concluded that ADSCs could trigger tumour growth from active cancer cells, but not from dormant ones. Moreover, ADSCs promoted tumour growth only when transplanted at the beginning of the neoplastic process.…”

Section: Neoplastic Degeneration Of the Adscs Or Activation Of Dormanmentioning

confidence: 99%