Dornase Alfa in Russia: 15 Years Later. Efficacy of the Drug in the Basic Treatment in Children With Cystic Fibrosis

Simonova, O.; Лукина, О Ф

doi:10.15690/vsp.v11i2.226

Cited by 6 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Препарат Тигераза ® (дорназа альфа) хорошо переносится пациентами, нежелательная реакция была отмечена только в одном случае, которая сопровождалась продолжительным сухим кашлем, который не прекращался более 2 ч и не сопровождался отхождением мокроты. Надо отметить, что дорназа альфа занимает особое место среди препаратов группы муколитиков, т. к. помимо муколитического свой ства препарат обладает еще противовоспалительным и антибактериальным эффектами [21]. Дорназа альфа действует на все три звена порочного круга муковисцидоза -обструкцию, инфекцию и воспаление.…”

Section: Cystic Fibrosisunclassified

Characteristics of CF patients over 18 years of age in the Republic of Tatarstan

Shakirova,

Gizatullina

2023

Medicinskij sovet

View full text Add to dashboard Cite

Introduction. Cystic fibrosis is a hereditary disease characterized by the defeat of all exocrine glands, vital organs and systems. Currently, the life expectancy of patients with cystic fibrosis is increasing due to the development of new therapies.Goal. Analysis of the results of a comprehensive examination of patients with cystic fibrosis under the supervision of a pulmonologist of Republican Clinical Hospital (RCH) of the Ministry of Health of the Republic of Tatarstan.Materials and methods. The analysis of the database of patients with cystic fibrosis, older than 18 years, registered in the Regional Center of cystic fibrosis of the Republic of Tatarstan (RT).Results. As of April 2023, 47 patients over the age of 18 with a diagnosis of cystic fibrosis were registered in the RCH of the Ministry of Health of the Republic of Tatarstan. The diagnosis was made on the basis of a positive sweat sample and/or a genetic study. The age of patients is from 18 to 39 years (26.1 ± 1.1 years). Women – 49%, men – 51%. Median body weight – 51.5 kg, height – 165 cm, BMI – 18.05 kg/m2. 25 patients (53.2%) had a BMI of less than 18.5 kg/m2. Among patients in RT, the most common mutation is F508del. When assessing the microbiological profile of the respiratory tract, chronic infection was detected in 37 patients (78.7%). Ps. aeruginosa (66.0%) and S.aureus (35.6%) were the most frequently sown. The average FVC indicators were 72.6 ± 4.3% predicted values, the average FEV1 indicators were 61.6 ± 28.1% predicted values.Conclusion. On the territory of the Republic of Tatarstan in patients with cystic fibrosis, the F508del mutation was detected in 30 (66.7%) adult patients, 9 of whom receive targeted therapy elecsacaftor / tezacaftor / ivacaftor+ ivacaftor with a pronounced positive effect. The high incidence of P. aeruginosa infection (66.0%) and a decrease in respiratory function among adult patients indicate a more severe course of cystic fibrosis.

show abstract

Section: Cystic Fibrosisunclassified

Characteristics of CF patients over 18 years of age in the Republic of Tatarstan

Shakirova,

Gizatullina

2023

Medicinskij sovet

View full text Add to dashboard Cite

show abstract

“…Дорназа альфа относится к ферментным (протеолитическим) муко-литикам и представляет собой особое химическое веще-ство [4,15], что и является основанием для ее примене-ния в качестве базисной терапии в постоянном режиме с момента постановки диагноза «Муковисцидоз».…”

unclassified

The Algorithm of Complex Syndrome-Oriented Therapy in Children With Cystic Fibrosis: A Modern Approach

Горинова¹,

Simonova²,

Томилова³

et al. 2013

Vopr. sovr. pediatr.

Self Cite

View full text Add to dashboard Cite

The National Consensus Project* «cystic Fibrosis: Definition, Diagnostic Criteria, and Therapy». Section «inhalation Therapy» (Abridged)

Amelina¹,

Asherova²,

Волков

et al. 2014

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

Dornase Alfa in Russia: 15 Years Later. Efficacy of the Drug in the Basic Treatment in Children With Cystic Fibrosis

Cited by 6 publications

References 8 publications

Characteristics of CF patients over 18 years of age in the Republic of Tatarstan

Characteristics of CF patients over 18 years of age in the Republic of Tatarstan

The Algorithm of Complex Syndrome-Oriented Therapy in Children With Cystic Fibrosis: A Modern Approach

The National Consensus Project* «cystic Fibrosis: Definition, Diagnostic Criteria, and Therapy». Section «inhalation Therapy» (Abridged)

Contact Info

Product

Resources

About