2006
DOI: 10.1016/j.heares.2006.03.011
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Dorsal cochlear nucleus response properties following acoustic trauma: Response maps and spontaneous activity

Abstract: Recordings from single neurons in the dorsal cochlear nucleus (DCN) of unanesthetized (decerebrate) cats were done to characterize the effects of acoustic trauma. Trauma was produced by a 250 Hz band of noise centered at 10 kHz, presented at 105-120 dB SPL for 4 h. After a one-month recovery period, neurons were recorded in the DCN. The threshold shift, determined from compound actionpotential audiograms, showed a sharp threshold elevation of about 60 dB at BFs above an edge frequency of 5-10 kHz. The response… Show more

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Cited by 32 publications
(17 citation statements)
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References 86 publications
(121 reference statements)
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“…This effect could be based on neuronal hyperactivity. This would be in line with the finding of several electrophysiological studies detecting an increase in spontaneous neuronal firing rates within a few days after noise trauma (Brozoski et al, 2002;Kaltenbach et al, 1998;Ma and Young, 2006) and might be caused by a loss of inhibitory mechanisms Wang et al, 2009). The impaired ascending structures, the DCN and the MGB, are supposed to play a fundamental role in auditory reorganization after loss of external input resulting in hearing deficits (Kaltenbach et al, 2005;Kamke et al, 2003).…”
Section: Pts Related Effectssupporting
confidence: 86%
“…This effect could be based on neuronal hyperactivity. This would be in line with the finding of several electrophysiological studies detecting an increase in spontaneous neuronal firing rates within a few days after noise trauma (Brozoski et al, 2002;Kaltenbach et al, 1998;Ma and Young, 2006) and might be caused by a loss of inhibitory mechanisms Wang et al, 2009). The impaired ascending structures, the DCN and the MGB, are supposed to play a fundamental role in auditory reorganization after loss of external input resulting in hearing deficits (Kaltenbach et al, 2005;Kamke et al, 2003).…”
Section: Pts Related Effectssupporting
confidence: 86%
“…Further evidence that fusiform cells become hyperactive following intense sound exposure has also been presented by others (Brozoski et al 2002;Dehmel et al 2012;Li et al 2011;Pilati et al 2011;Shore et al 2008). A single exception that did not show increases in activity of any cell type in the DCN following noise exposure was a study conducted in decerebrate animals (Ma and Young 2006).…”
Section: Discussionmentioning
confidence: 62%
“…Furthermore, decreased expression of potassium channels was found in the cochlear nucleus (Holt et al, 2006) and the inferior colliculus (Cui et al, 2007) after bilateral cochlear ablation, indicating that the excitability of neurons in these nuclei might have been increased. Furthermore, the broadly tuned response maps of DCN neurons with mostly excitatory responses after acoustic trauma (Ma and Young, 2006) could also be explained by increased excitatory and decreased inhibitory synaptic strengths as a result of homeostatic plasticity.…”
Section: Discussionmentioning
confidence: 99%