Dorsal onlay versus dorsal inlay buccal mucosal graft urethroplasty for anterior urethral stricture: a single centre retrospective study

Bagchi, Puskal Kumar; Ghanghoria, Ashish; Rajeev, T P; Barua, Sasanka Kumar; Sarma, Debojit; Phukan, Mandeep

doi:10.18203/2349-2902.isj20200830

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…In the study of Vasudeva et al [21] who compared the dorsal onlay versus ventral onlay for treating bulbar urethral stricture by BMG, they reported 92.5% success rate when using dorsal onlay technique and 90% success rate when using ventral onlay procedure. In a metanalysis that was done by Bagchi et al [22] , who compared between the different types of grafts that used in urethral reconstructions after stricture, they found that the success rate when using BMG is 85.9%, which is in line with our study findings.…”

Section: Discussionsupporting

confidence: 92%

“…The type of the operative procedure was significantly affected the success rate (P value < 0.003) as it was high in dorsal onlay (97.1%) more than ventral onlay (66.6%), which disagrees with the result of Bagchi et al [22] , who found no significant difference between the two procedures as regarding the success rate. Volume of blood loss significantly affects the success rate (P value = 0.001) as the percentage of succeed patients in those who lost < 500 ml blood was 87.3%% and in those who lost > 500 ml was 0%.…”

Section: Discussioncontrasting

confidence: 60%

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Outcomes of Buccal Mucosal Graft Urethroplasty for Long-Segment Anterior Urethral Strictures

2023

The Egyptian Journal of Hospital Medicine

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Background: A prevalent urologic illness in men, urethral stricture is accompanied by a significant financial burden as well as a decline in the quality of life for afflicted men and their families. Buccal mucosal grafts (BMG) are now often utilised to repair lengthy anterior urethral strictures. Objective: To assess the effectiveness of buccal mucosal graft urethroplasty for long-segment anterior urethral stricture resulting from various etiologies, including previously complex hypospadias repair. Patients and methods: This prospective cohort study included 65 patients with long-segment anterior urethral stricture due to different etiologies. Complete medical history and physical examination were done to each patient during enrollment. Urological investigations were done to confirm the diagnosis and to determine the accurate site of urethral stricture. All patients underwent buccal mucosal graft urethroplasty and all outcomes were reported. Results: The mean age of the patients was 27.6±13.15 SD years. Regarding the presenting symptoms, 63.1% of the panties complained from obstructive symptoms, and 39.9% complained from retention symptoms. Post hypospadias repair failure was the main etiology of strictures (n = 24; 36.9%). The success rate was found to be 84.6%, while 15.4% had recurrent stricture. The volume of blood loss was significantly affected success rate (P value=0.001). Also, the success rate was significantly affected by age (P value < 0.04), stricture site (P value < 0.006), cause of stricture (P value < 0.01), type of BMG urethroplasty (P value < 0.003), wound infection (P value < 0.001), hematoma formation (P value < 0.01), and catheterization time (P value < 0.001). Conclusion: BMG either dorsal or ventral onlay is an effective technique for treatment of urethral strictures of different etiologies.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 60%

Outcomes of Buccal Mucosal Graft Urethroplasty for Long-Segment Anterior Urethral Strictures

2023

The Egyptian Journal of Hospital Medicine

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“…However the results obtained from the dorsal onlay urethroplasty aided with the buccal mucosal graph and vaginal wall graph were compared. These treatment are proved to be more effective with better results and less reported complications [9][10] .…”

Section: Introductionmentioning

confidence: 99%

Dorsal Onlay Urethroplasty Using Buccal Mucosal Graft and Vaginal Wall Graft for Female Urethral Stricture; Outcome of a Tertiary Care Hospital

Hassan¹,

Siraj²,

Khan³

et al. 2022

PJMHS

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Background: Normally female urethral stricture (FUS) is uncommon and underdiagnosed condition. It is raising a diagnostic challenge for the physicians. It is the one of the rarely known urological entity. Urethral dilatation is the traditionally used treatment for urethral stricture (FUS). The female urethroplasty have shown the promising outcomes. Objective: The objective of the study was to compare the outcome of the dorsal onlay urethoplasty FU obtained by using buccal mucosal graft and vaginal wall graft. The FU is more effective treatment for female urethral stricture (FUS) as compared to the repeated dilatation. Study design: It is a retrospective study with the statistical approach, conducted at Urology Department, Pakistan Institute of Medical Sciences Islamabad from June 2021 to November 2021. Material and Methods: The women who underwent the dorsal onlay urethropasty at the urology department of the hospital were included in the study. The outcomes of BMG and VWG were compared. The re-intervention was marked as failure. The association symptom score, postvoid residual urine (PVR), cystourethrogram, cystoscopy and uretheral calibration were included in the assessment. Operating time, catheter time, etiology, location, length, prior interventions and suprapubic cystostomy were the other parameters that was also reported. For the statistical analysis the Mann-Whitney test, t-test and proportion test was performed. Results: The calculated mean age of the patients included in the group was 48 years. Its range was between the 26 to 76 years. The women visited the urology department of the hospital from June 2021 to June 2022. The average follow-up was for 26 months. The AUA symptoms changes from 22 to 6, Qmax from 4ml/s to 26ml/s and RVR from 185ml to 7ml. The operating time was the only parameter showed the difference, while other remained the same. The 94% was the overall urethral patency rate. Conclusion: For the substitution of dorsal onlay urethroplasty the use of VWG and BMG is highly recommended. It is an efficient and reliable treatment method. There are very low chances of complication and it has an easy protocol. Apparently, no specific change was observed in the FUS treatment by BMG and VWG. Keywords: Female urethral stricture (FUS), buccal mucosal graft, vaginal wall graft, postvoid residual urine (PVR), dorsal onlay urethroplasty.

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Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways

Chen,

Li,

Dai

et al. 2024

Biomed. Mater.

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Objective:The study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) on human urinary-derived stem cells (hUSCs) viability within 3D cell-laden gelatin methacryloyl (GelMA) scaffolds.Methods:hUSCs were integrated into GelMA bio-inks at concentrations ranging from 2.5% to 10% (w/v) and then bioprinted using a volumetic-based method. Subsequent exposure of these scaffolds to LIPUS under varying parameters or sham irradiation aimed at optimizing the LIPUS treatment. Assessment of hUSCs viability employed Cell Counting Kit-8 (CCK8), cell cycle analysis, and live&dead cell double staining assays. Additionally, Western blot analysis was conducted to determine protein expression levels.Result:With 3D bio-printed cell-laden GelMA scaffolds successfully constructed, LIPUS promoted the proliferation of hUSCs. Optimal LIPUS conditions, as determined through CCK8 and live&dead cell double staining assays, was achieved at a frequency of 1.5 MHz, a spatial-average temporal-average intensity (ISATA) of 150 mW/cm2, with an exposure duration of 10 minutes per session administered consecutively for two sessions. LIPUS facilitated the transition from G0/G1 phase to S and G2/M phases and enhanced the phosphorylation of ERK1/2 and PI3K-Akt. Inhibition of ERK1/2 (U0126) and PI3K (LY294002) significantly attenuated LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt respectively, both of which decreased the hUSC viability within 3D bio-printed GelMA scaffolds.Conclusion:Applying a LIPUS treatment at an ISATA of 150 mW/cm2 promotes the growth of hUSCs within 3D bio-printed GelMA scaffolds through modulating ERK1/2 and PI3K-Akt signaling pathways.

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Dorsal onlay versus dorsal inlay buccal mucosal graft urethroplasty for anterior urethral stricture: a single centre retrospective study

Cited by 4 publications

References 31 publications

Outcomes of Buccal Mucosal Graft Urethroplasty for Long-Segment Anterior Urethral Strictures

Outcomes of Buccal Mucosal Graft Urethroplasty for Long-Segment Anterior Urethral Strictures

Dorsal Onlay Urethroplasty Using Buccal Mucosal Graft and Vaginal Wall Graft for Female Urethral Stricture; Outcome of a Tertiary Care Hospital

Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways

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