Dorsal raphe nucleus acetylcholine-mediated neurotransmission modulates post-ictal antinociception: The role of muscarinic and nicotinic cholinergic receptors

Oliveira, Reinaldo Cunha de; Oliveira, Ricardo de; Biagioni, Audrey Franceschi; Falconi‐Sobrinho, Luiz Luciano; Coimbra, Norberto Cysne

doi:10.1016/j.brainres.2015.11.014

Cited by 5 publications

(2 citation statements)

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“…Moreover, the DR is also implicated in the postictal antinociception. Neurochemical lesion of the DR induced a significant decrease of the postictal analgesia and pre-treatment of the DR with atropine or mecamylamine decreased the postictal antinociceptive phenomenon in PTZ model in male Wistar rats [98,99]. Additional evidence demonstrated the recruitment of 5-HT 1a/1b , 5-HT 2a/2c , 5-HT 6 , and 5-HT 7 receptors of the DR [100,101], in addition to 5-HT 2 receptor of the RMg [102], in the postictal antinociception.…”

Section: The Raphe Nuclei In Other Comorbidities Of Epilepsymentioning

confidence: 89%

The diverse role of the raphe 5-HTergic systems in epilepsy

et al. 2022

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The raphe nuclei comprise nearly all of 5-hydroxytryptaminergic (5-HTergic) neurons in the brain and are widely acknowledged to participate in the modulation of neural excitability. "Excitability-inhibition imbalance" results in a variety of brain disorders, including epilepsy. Epilepsy is a common neurological disorder characterized by hypersynchronous epileptic seizures accompanied by many psychological, social, cognitive consequences. Current antiepileptic drugs and other therapeutics are not ideal to control epilepsy and its comorbidities. Cumulative evidence suggests that the raphe nuclei and 5-HTergic system play an important role in epilepsy and epilepsy-associated comorbidities. Seizure activities propagate to the raphe nuclei and induce various alterations in different subregions of the raphe nuclei at the cellular and molecular levels. Intervention of the activity of raphe nuclei and raphe 5-HTergic system with pharmacological or genetic approaches, deep brain stimulation or optogenetics produces indeed diverse and even contradictory effects on seizure and epilepsy-associated comorbidities in different epilepsy models. Nevertheless, there are still many open questions left, especially regarding to the relationship between 5-HTergic neural circuit and epilepsy. Understanding of 5-HTergic network in a circuit-and molecule-specific way may not only be therapeutically relevant for increasing the drug specificity and precise treatment in epilepsy, but also provide critical hints for other brain disorders with abnormal neural excitability. In this review we focus on the roles of the raphe 5-HTergic system in epilepsy and epilepsy-associated comorbidities. Besides, further perspectives about the complexity and diversity of the raphe nuclei in epilepsy are also addressed.

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Section: The Raphe Nuclei In Other Comorbidities Of Epilepsymentioning

confidence: 89%

The diverse role of the raphe 5-HTergic systems in epilepsy

et al. 2022

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“…Moreover, atropine has antagonized intrathecal injection of physostigmine induced antinociception [42]. It has been reported that in the dorsal raphe nucleus, the muscarinic and nicotinic cholinergic receptors are mediated in post-ictal analgesia [43]. Incision-induced mechanical hyperalgesia has been reduced by bethanechol (a muscarinic agonist) [44].…”

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confidence: 99%

The Effect of Muscarinic Receptor Modulators on the Antinociception Induced by CB2 Receptor Agonist, JWH133 in Mice

et al. 2016

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There is no published study regarding the interaction between muscarinic receptor modulators and antinociception induced by cannabinoid receptor (CB) agonist. The effect of pilocarpine (a muscarinic agonist) and atropine (a muscarinic antagonist) on JWH-133 (a CB agonist) induced analgesia in mice was studied. First the analgesic effect of JWH-133 (0.001-1 mg/Kg) or pilocarpine (2.5-20 mg/kg) or atropine (0.2-5 mg/kg) was evaluated. Subsequently, the effect of co-administration of pilocarpine (2.5 mg/kg) or atropine (5 mg/kg) and JWH-133 (0.001-1 mg/Kg) were studied too. JWH-133 and pilocarpine provoked antinociception in mice but atropine did not. Pilocarpine potentiated the analgesic effect of JWH-133 but atropine antagonized that. It can be concluded that JWH-133 induced antinociception is affected by muscarinic receptor modulators in mice.

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Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception

Oliveira

Biagioni

et al. 2016

Brain Research Bulletin

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Dorsal raphe nucleus acetylcholine-mediated neurotransmission modulates post-ictal antinociception: The role of muscarinic and nicotinic cholinergic receptors

Cited by 5 publications

References 65 publications

The diverse role of the raphe 5-HTergic systems in epilepsy

The diverse role of the raphe 5-HTergic systems in epilepsy

The Effect of Muscarinic Receptor Modulators on the Antinociception Induced by CB2 Receptor Agonist, JWH133 in Mice

Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception

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