2019
DOI: 10.1101/601617
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Dorsal-to-ventral neocortical expansion is physically primed by ventral streaming of early embryonic preplate neurons

Abstract: Mammalian neocortex exhibits a disproportionally "luxurious" representation of somatotopies in its lateral region, which depends on dorsal-to-ventral expansion of the pallium during development. Despite recent studies elucidating the molecular mechanisms underlying the cortical arealization/patterning, we know very little about how the cortex expands ventrally and the nature of the underlying force-generating events.We found that neurons born earliest (at embryonic day 10 [E10]) in the mouse pallium migrated v… Show more

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“…Cultures of cerebral walls were prepared as described previously (Saito et al, ; Shinoda et al, ). Briefly, cerebral walls were microsurgically processed and embedded (ventricular surface top) in a polystyrene cell culture dish (Corning) with Atelocell IAC‐30 collagen gel (Koken) at a concentration of 0.8 mg/ml.…”
Section: Methodsmentioning
confidence: 99%
“…Cultures of cerebral walls were prepared as described previously (Saito et al, ; Shinoda et al, ). Briefly, cerebral walls were microsurgically processed and embedded (ventricular surface top) in a polystyrene cell culture dish (Corning) with Atelocell IAC‐30 collagen gel (Koken) at a concentration of 0.8 mg/ml.…”
Section: Methodsmentioning
confidence: 99%