Dorsolateral prefrontal cortex and hippocampus sustain impulsivity and aggressiveness in borderline personality disorder

Sala, Michela; Caverzasi, Edgardo; Lazzaretti, Matteo; Morandotti, Niccolò; Vidovich, G. De; Marraffini, Elisa; Gambini, Francesca; Isola, Miriam; Bona, Manuela De; Rambaldelli, Gianluca; d'Allio, Giorgio; Barale, Francesco; Zappoli, F.; Brambilla, Paolo

doi:10.1016/j.jad.2010.11.036

Cited by 89 publications

(54 citation statements)

References 44 publications

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“…The vector was prepared in such a way to ensure overexpression of the NLGN2 gene. Studies on the role of the hippocampus in aggressive and other social behaviors have been relatively new [73][74][75][76]. Changes of social behavior and altered inhibitory synaptic transmission, hence modification of the excitation/ inhibition (E/I) balance, have been observed.…”

Section: Neuroligin-2mentioning

confidence: 99%

Genetic and non-genetic determinants of aggression in combat sports

2014

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Human aggression/impulsivity-related traits are influenced by complex genetic and non-genetic factors. The aggression/anxiety relationship is controlled by highly conserved brain regions including the amygdala, hypothalamus and periaqueductal gray of the midbrain, which is responsible for neural circuits triggering defensive, aggressive, or avoidant behavioral models. The social behavior network consists of the medial amygdala, medial hypothalamus and periaqueductal gray, and it positively modulates reactive aggression. An important role in the incidence of aggressive behavior is played by secreted factors such as testosterone, glucocorticoids, pheromones, as well as by expression of genes such as neuroligin-2, monoamine oxidase A, serotonin transporters, etc. The authors deliberate whether aggression in sport is advantageous (or even indispensable), or to what extent it can hamper attainment of sport success. Methods of reducing and inhibiting expression of aggression in athletes are indicated.

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Section: Neuroligin-2mentioning

confidence: 99%

Genetic and non-genetic determinants of aggression in combat sports

2014

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“…In the DSM-IV-TR five of the nine criteria for borderline personality disorder can be interpreted as manic or hypomanic symptoms including impulsivity, recurrent suicidal behavior, affective instability, inappropriate and intense anger, and transient stress-related paranoid ideas (APA, 2000). There is also neurophysiological research associating kindling phenomenon and misfiring related to specific regions of the brain in borderline personality disorder (Berdahl, 2010;Diaz-Marsa et al, 2011;Sala et al, 2011). The neurophysiological support aligns more with an Axis I disorder than Axis II.…”

Section: Confluence Of Borderline Personality and Bipolar Disordersmentioning

confidence: 99%

The Plight of Personality Disorders in theDSM-5

Limandri

2012

Issues in Mental Health Nursing

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This article provides a brief history of the development of the Diagnostic and Statistical Manual of Mental Disorders published by the American Psychiatric Association, and how it relates to the proposed fifth edition to be published in 2013. Of particular emphasis is Axis II and how this axis is likely to be restructured. The reconceptualization of the nosology for personality disorders has been controversial since the publication of the DSM-III-R (Wilson, 1993). In both the clinical and academic communities, ongoing debate about diagnostic classification of personality disorders has been common. One recurrent theme among the deliberations on diagnosis and personality disorder focuses on the question of whether distinct (categorical) diagnoses exist or whether diagnoses are dimensionally related to each other in some empirically determined way. The proposed changes for Axis II in the DSM-5 are likely to bridge the gap between these two arguments by revamping the overall criteria and discarding the three currently used diagnostic clusters. The resulting nosology proposes six personality disorders with common factors in Criteria A and Criteria B. However, a major concern and a continuing problem not likely to be resolved in this edition is the symptom resemblance of borderline personality disorder and bipolar disorder. This article suggests some ways the revised DSM might affect mental health nursing practice.

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“…Hippocampal evidence, however, has been more consistent in implicating reduced structural volume in BPD patients relative to healthy controls (Driessen et al, 2000; Sala et al, 2011; Schmahl et al, 2009; Schulze et al, 2016). However, the relationship between individual differences in hippocampal volume and self-reported anxiety and affective instability is less clear, although some evidence has shown that, among BPD patients, relatively reduced hippocampal volume predicts greater aggressiveness (Sala et al, 2011; Zetzsche et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…However, the relationship between individual differences in hippocampal volume and self-reported anxiety and affective instability is less clear, although some evidence has shown that, among BPD patients, relatively reduced hippocampal volume predicts greater aggressiveness (Sala et al, 2011; Zetzsche et al, 2007). Thus, we were motivated to examine hippocampus as a region-of-interest in this study.…”

Section: Introductionmentioning

confidence: 99%

Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms

Denny

Fan²,

Liu

et al. 2016

Journal of Affective Disorders

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Background Borderline personality disorder (BPD) and avoidant personality disorder (AvPD) are characterized by hyper-reactivity to negatively-perceived interpersonal cues, yet they differ in degree of affective instability. Recent work has begun to elucidate the neural (structural and functional) and cognitive-behavioral underpinnings of BPD, although some initial studies of brain structure have reached divergent conclusions. AvPD, however, has been almost unexamined in the cognitive neuroscience literature. Methods In the present study we investigated group differences among 29 BPD patients, 27 AvPD patients, and 29 healthy controls (HC) in structural brain volumes using voxel-based morphometry (VBM) in five anatomically-defined regions of interest: amygdala, hippocampus, medial prefrontal cortex (MPFC), dorsolateral prefrontal cortex (DLPFC), and anterior cingulate cortex (ACC). We also examined the relationship between individual differences in brain structure and self-reported anxiety and affective instability in each group. Results We observed reductions in MPFC and ACC volume in BPD relative to HC, with no significant difference among patient groups. No group differences in amygdala volume were found. However, BPD and AvPD patients each showed a positive relationship between right amygdala volume and state-related anxiety. By contrast, in HC there was an inverse relationship between MPFC volume and state and trait-related anxiety as well as between bilateral DLPFC volume and affective instability. Limitations Current sample sizes did not permit examination of gender effects upon structure-symptom correlations. Conclusions These results shed light on potentially protective, or compensatory, aspects of brain structure in these populations–namely, relatively reduced amygdala volume or relatively enhanced MPFC and DLPFC volume.

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Dorsolateral prefrontal cortex and hippocampus sustain impulsivity and aggressiveness in borderline personality disorder

Cited by 89 publications

References 44 publications

Genetic and non-genetic determinants of aggression in combat sports

Genetic and non-genetic determinants of aggression in combat sports

The Plight of Personality Disorders in theDSM-5

Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms

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