2019
DOI: 10.1038/s41593-019-0378-3
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Dorsolateral prefrontal neurons mediate subjective decisions and their variation in humans

Abstract: Subjective decisions play a vital role in human behavior because, while often grounded in fact, they are inherently based on personal beliefs that can vary broadly within and between individuals. While these properties set subjective decisions apart from many other sensorimotor processes and are of wide sociological impact, their single-neuronal basis in humans is unknown. Here, we find cells in the dorsolateral prefrontal cortex (dlPFC) that reflected variations in the subjective decisions of humans when perf… Show more

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Cited by 23 publications
(19 citation statements)
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“…In total, we recorded from 212 putative neurons across 17 recording sessions for an average of 1.5 recording sessions per participant in the main task. The average number of neurons isolated per recording session was 12 ± 1, amounting to approximately 2 well-isolated units per electrode per session across the 5 recording electrodes 33 , 34 , 38 , 39 .…”
Section: Methodsmentioning
confidence: 99%
“…In total, we recorded from 212 putative neurons across 17 recording sessions for an average of 1.5 recording sessions per participant in the main task. The average number of neurons isolated per recording session was 12 ± 1, amounting to approximately 2 well-isolated units per electrode per session across the 5 recording electrodes 33 , 34 , 38 , 39 .…”
Section: Methodsmentioning
confidence: 99%
“…However, this hypothesis should be directly tested in future studies. Moreover, we suggest that increased activity in the dlPFC corresponds to more general decisional processes in the detection task ( Kim and Shadlen, 1999 ; Miller and Cohen, 2001 ; Carter and van Veen, 2007 ; Hanks et al, 2015 ; Jamali et al, 2019 ) because the dlPFC is typically not related to self-referential processing ( Tacikowski et al, 2017 ).…”
Section: Discussionmentioning
confidence: 90%
“…The lateral PFC is involved in logical top-down cognitive processes (Chan et al, 2008 ) and functions in an emotionally neutral context (Zelazo and Carlson, 2012 ). Moreover, the dorsolateral prefrontal cortex (DLPFC) is involved in working memory, attention, executive function, dual tasks, and other related areas (Adleman et al, 2002 ; Badre and Wagner, 2004 ; Harty et al, 2014 ; Huang et al, 2017 ; Brzezicka et al, 2019 ; Jamali et al, 2019 ; Panikratova et al, 2020 ). Imaging studies using functional magnetic resonance imaging have also implicated the DLPFC in bimanual coordination tasks (Beets et al, 2015 ) and explicit sequence learning (Schendan et al, 2003 ; Meehan et al, 2011 ).…”
Section: Introductionmentioning
confidence: 99%