Dorsoventral differential distribution of collagen type XIV around the spinal cord is regulated by the ectoderm

Fukushima, Mikiko; Hirano, Shigeki; Tanaka, Hideaki

doi:10.1046/j.1440-169x.1999.00472.x

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Collagen XIV is thought to control collagen I fibrillogenesis during embryonic development (as has been supported by our results, it inversely correlates with fibril diameter and premature growth), as well as differentiation 4 , 66 , 67 . Interestingly, in the chick embryo it is expressed in a gradient around the spinal cord 72 . Like Collagen XII, it is key for the hydration and thickness (and therefore transparency) of tissues 73 , supporting our macroscopic observations of a gel-like appearance in foetal NPs.…”

Section: Discussionmentioning

confidence: 99%

Matrisome Profiling During Intervertebral Disc Development And Ageing

Caldeira

Santa

Osório

et al. 2017

Sci Rep

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Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation. However, a thorough study of ECM profiling is needed, to better understand IVD development and age-associated degeneration. As so, iTRAQ LC-MS/MS analysis of foetus, young and old bovine NPs, was performed to define the NP matrisome. The enrichment of Collagen XII and XIV in foetus, Fibronectin and Prolargin in elder NPs and Collagen XI in young ones was independently validated. This study provides the first matrisome database of healthy discs during development and ageing, which is key to determine the pathways and processes that maintain disc homeostasis. The factors identified may help to explain age-associated IVD degeneration or constitute putative effectors for disc regeneration.

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