Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension

Traustason, Sindri; Hardarson, Sveinn Hákon; Gottfreðsdóttir, María Soffía; Eysteinsson, Þór; Karlsson, Robert Arnar; Stefánsson, Einar; Harris, Alon

doi:10.1136/bjo.2008.148460

Cited by 51 publications

(33 citation statements)

References 26 publications

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“…Previous literature has suggested the positive effect of IOP control on improved ocular blood flow and hence retinal oxygen saturation. 24,25 Further studies involving blood flow measurements and a larger sample size would be required for specific assessment of retinal SO 2 under different therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

Retinal Oxygen Saturation in Patients with Primary Open-angle Glaucoma Using a Non-flash Hypespectral Camera

Shahidi

Hudson

Tayyari

et al. 2016

Current Eye Research

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Section: Discussionmentioning

confidence: 99%

Retinal Oxygen Saturation in Patients with Primary Open-angle Glaucoma Using a Non-flash Hypespectral Camera

Shahidi

Hudson

Tayyari

et al. 2016

Current Eye Research

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“…Diseases investigated so far include diabetic retinopathy (Hammer et al, 2009, Hardarson andStefansson, 2012b), glaucoma , Traustason et al, 2009) and retinal vein occlusion Stefansson, 2010, Hardarson andStefansson, 2012a). Ease of use and low variability paired with high sensitivity and specificity are essential for any diagnostic technology.…”

Section: Introductionmentioning

confidence: 99%

The effect of simulated cataract light scatter on retinal vessel oximetry

Patel

Hudson

Flanagan

et al. 2013

Experimental Eye Research

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To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations.Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oxymetry Modul, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter.

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“…This improvement in blood flow has also been reported in retinal arteries, with dorzolamide accelerating the arteriovenous passage of fluorescein dye when compared with a beta-blocker . Topical carbonic anhydrase inhibitors may also play a role in retinal oxygenation because withdrawal of the drug leads to a decrease in arterial and venous saturation (Traustason, 2009). However, this class of drug is mostly used in association with other drugs, namely, beta-blockers.…”

Section: Ophthalmological Therapiesmentioning

confidence: 99%