Dos and Don'ts that are Issued through Radiolabeling Process of DMSA (Dimercaptosuccinic Acid) by 99mTco4- as 99mTc-DMSA(III), the Gold Standard Radiopharmaceutical for Renal Cortical Scintigraphy

Abnormal Biologic Distribution Related to Normal Saline Among99mTc-Dimercaptosuccinic Acid Scans

“…In this study, 26 patients with abnormal biodistribution had renal problems with high creatinine levels; therefore, this was the explanation for high background and liver uptake among these patients. In addition, liver and spleen diseases may also influence the biodistribution of 99m Tc-DMSA (5). Two of the evaluated patients in our study who demonstrated abnormal biodistribution had liver and spleen diseases.…”

“…On the other hand, Fakhari et al (5) reported that dehydrated patients have less kidney uptake of 99m Tc-DMSA because of decreasing kidney capacity, leading to abnormal biodistribution of 99m Tc-DMSA. Hydration significantly alters the biologic distribution of 99m Tc-DMSA; thus, maintaining adequate hydration is an important factor to decrease background levels of 99m Tc-DMSA (9).…”

“…Renal scintigraphy is a nuclear medicine technique that uses medical radioisotopes to evaluate renal function (3). 99m Tc-dimercaptosuccinic acid ( 99m Tc-DMSA) is the most routinely used radiopharmaceutical for renal cortex imaging because of its nuclear properties, ready availability, low cost (4), accumulation in the renal cortex, and guidance in detecting any morphologic parenchymal abnormality (5). Uptake of 99m Tc-DMSA in the kidneys, as normal biodistribution, provides an index to evaluate functional tubular mass, which depends on the proximal tubular cell membrane transport function and renal blood flow (3).…”