Dosage adjustment in renal insufficiency.

Mawer, G. E.

doi:10.1111/j.1365-2125.1982.tb01349.x

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Elimination by hemodialysis can be com pensated by either adding the drug to the hemodialysis solution or by substitution of the amount of drug being eliminated by dial ysis [36]. In the case of addition of the drug, the hemodialysis solution concentration has to be the same as in the blood.…”

Section: Volume Of Distributionmentioning

confidence: 99%

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Tranquilizers, Analgetics and Antidepressants in Patients Treated with Hemodialysis

Forycki¹,

Martens²,

Thalhofer³

et al. 1985

Blood Purif

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Tranquilizers, analgetics and antidepressants are applied in different ranges in the treatment of patients on hemodialysis. Due to many different pharmacokinetic properties, no perfect rules for dosage in acute or chronic hemodialysis exist. Adequate applicable drugs without adaptation disregarding different states of renal failure are such with predominate hepatic metabolism and elimination or with inactive metabolites.In the management of acute renal failure, usually in connection with multiple organic disorders, a nonschematic, individually adapted therapy is indicated. In some substances, therapy can be determined by control of plasma concentration levels, in other drugs dosage is possible exclusively according to clinical effects. Substances with side effects on coagulation or acid-base equilibrium should be avoided. It is recommendable to get well acquainted with one substance out of each group in order to avoid polypragmasy.

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Section: Volume Of Distributionmentioning

confidence: 99%

“…In the management of dosage adaptation in re nal failure, two methods are common: either to enlarge the intervals between two applica tions or the reduction of each single dose using constant intervals [28,34,36]. The method of application also depends on phar macokinetics.…”

Section: Volume Of Distributionmentioning

confidence: 99%

Tranquilizers, Analgetics and Antidepressants in Patients Treated with Hemodialysis

Forycki¹,

Martens²,

Thalhofer³

et al. 1985

Blood Purif

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Paracetamol disposition and metabolite kinetics in patients with chronic renal failure

Prescott

Speirs

Critchley

et al. 1989

Eur J Clin Pharmacol

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The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life of paracetamol from 2 to 8 h was similar in the 3 groups (2.1 to 2.3 h) but from 8 to 24 h it disappeared much more slowly in the renal failure patients (half-life 11.7 compared with 4.9 h in the healthy volunteers). Plasma concentrations of paracetamol glucuronide and sulphate conjugates were greatly increased in the patients with moderate renal failure and the mean plasma half-lives were 30.5 and 21.8 h respectively compared with about 3 h in the healthy volunteers. Plasma concentrations of these metabolites were even higher in the dialysis patients and there was no significant fall over 24 h. The cysteine and mercapturic acid conjugates of paracetamol could only be measured in plasma in the patients with renal failure and concentrations were very low. The fractional urinary recovery of paracetamol and its glucuronide, sulphate, cysteine and mercapturic acid conjugates was similar in healthy volunteers and patients with moderate renal failure.(ABSTRACT TRUNCATED AT 250 WORDS)

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Urinary tract infection.

Greenwood¹,

Slack²

1982

Brit J Clinical Pharma

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Dosage adjustment in renal insufficiency.

Cited by 4 publications

References 42 publications

Tranquilizers, Analgetics and Antidepressants in Patients Treated with Hemodialysis

Tranquilizers, Analgetics and Antidepressants in Patients Treated with Hemodialysis

Paracetamol disposition and metabolite kinetics in patients with chronic renal failure

Urinary tract infection.

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