2014
DOI: 10.1007/s40264-014-0209-0
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Dosage Effects of Histamine-2 Receptor Antagonist on the Primary Prophylaxis of Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated Peptic Ulcers: A Retrospective Cohort Study

Abstract: High-dose H2RA showed greater effectiveness than low-dose H2RA in the primary prophylaxis of NSAID-associated PUs in short-term new users.

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Cited by 21 publications
(12 citation statements)
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“…The estimated effects of PPI use for preventing ulcer complications in this systematic review are similar to observational study estimates, ranging in RR or odds ratio from 0.2 to 0.33 . Some observational studies suggested that H2RAs reduced the risk of clinical gastrointestinal events, though the quality of evidence was low.…”
Section: Discussionsupporting
confidence: 64%
“…The estimated effects of PPI use for preventing ulcer complications in this systematic review are similar to observational study estimates, ranging in RR or odds ratio from 0.2 to 0.33 . Some observational studies suggested that H2RAs reduced the risk of clinical gastrointestinal events, though the quality of evidence was low.…”
Section: Discussionsupporting
confidence: 64%
“…13 CDARS has been used for conducting high-quality, population-based studies. [13][14][15][16][17] A local study showed high coding accuracy in CDARS with a positive predictive value (PPV) of 90%. 18 Nonetheless, we conducted further validation on a sample of patients in this cohort to ensure the validity of our data set.…”
Section: Data Sourcementioning
confidence: 99%
“…CDARS has been used in previous epidemiologic studies. [16][17][18][19][20][21] Clinical practice research datalink. The CPRD contains the anonymized electronic primary care records for approximately 8.5% of the UK population with more than 5 million currently active patients and more than 13 million records dating back to 1987.…”
Section: Data Sources Clinical Data Analysis and Reporting Systemmentioning
confidence: 99%