Dosage of potassium citrate in the correction of urinary abnormalities in pediatric distal renal tubular acidosis patients

Domrongkitchaiporn, Somnuek; Khositseth, Sookkasem; Stitchantrakul, Wasana; Tapaneya-Olarn, W; Radinahamed, Piyanuch

doi:10.1053/ajkd.2002.30560

Cited by 48 publications

(20 citation statements)

References 19 publications

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“…Alkali therapy restores growth in children and prevents the progression of nephrocalcinosis at all ages. 1,13,14 Similarly, we treated all of the patients with RTA using alkali therapy.…”

Section: Discussionmentioning

confidence: 99%

Renal tubular acidosis in renal transplantation recipients

et al. 2010

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Aim: We aimed to investigate the prevalence, type, and possible risk factors of renal tubular acidosis (RTA) in Turkish patients with renal transplantation. Patients and method: The study included 66 adult renal transplantation recipients. We recorded the parameters of venous blood gas analysis including serum pH value, serum bicarbonate (HCO 3 ) concentration, presence of metabolic acidosis, which was defined as low HCO 3 (<22 mEq/L), and serum pH value (<7.35) together, and base excess and urine pH at the last follow-up. Creatinine clearance was determined from 24-hour collected urine samples. RTA was defined to be metabolic acidosis with normal serum anion gap and positive urine anion gap. Results: Mean age of 66 patients was 37.0 ± 10.4 years; 48 of 66 patients were male. RTA was found in 14 (21.2%) patients. Considering for differential diagnosis of RTA, 4 patients had type 2 RTA and 10 had type 1 RTA. On the contrary, type 4 RTA was observed in no patients. Creatinine clearance was meaningfully lower in acidosis group than in those of the nonacidosis group (55.16 ± 23.27 vs. 71.06 ± 28.14 mL/min; p = 0.028). HCO 3 was correlated with hemoglobin level (r = 0.423, p = 0.001) and creatinine clearance (r = 0.262, p = 0.034). It was inversely correlated with cyclosporine A (CsA) level (r = −0.499, p = 0.035). Conclusion: RTA is a common complication after kidney transplantation. It is related with low creatinine clearance, low hemoglobin level, and high CsA level. Particularly, the value of creatinine clearance is lower and the possibility of RTA is higher.

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“…Alkali therapy restores growth in children and prevents the progression of nephrocalcinosis at all ages. 1,13,14 Similarly, we treated all of the patients with RTA using alkali therapy.…”

Section: Discussionmentioning

confidence: 99%

Renal tubular acidosis in renal transplantation recipients

et al. 2010

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“…In young infants, as much as 5 to 8 mmol/kg per 24 h of citrate (or bicarbonate) may be needed, whereas amounts of about 3 to 4 mmol/kg per 24 h and 1 to 2 mmol/kg per 24 h are required in children and adults, respectively (39). Potassium citrate alone can also be used and, in children, an amount of 4 mmol/kg per 24 h is recommended (58). An appropriate dosage should correct successfully most of the urinary abnormalities, including hypercalciuria.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Renal Tubular Acidosis

Soriano¹

2002

Journal of the American Society of Nephrology

398

166

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“…119 Patients with dRTA generally have underlying hypocitraturia and are treated with alkali citrate. 120,121 Potassium citrate has demonstrated superior effects on urinary indices as compared to sodium citrate in patients with incomplete dRTA. 108 In patients with demonstrated dRTA treatment with 60-80 mEq daily of potassium citrate resulted in increased urine pH and urine citrate, decreased urine calcium, and significantly reduced stone formation.…”

Section: Index Patient 2: Pure Calcium Phosphate Stonementioning

confidence: 99%