Dose Analysis of BNCT Treatment Method for Rhabdomyosarcoma in the Head and Neck Regions Based on PHITS Code

Syamputra, Dhani Nur Indra; Sardjono, Yohannes; Mahmudah, Rida Siti Nuraini

doi:10.29037/ajstd.521

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Ionizing radiation has many forms, from alpha, beta, proton, or neutron particles, to X or gamma rays, and others. The main components that contribute to the total absorbed dose rate in BNCT are the elastic interaction of incident neutrons with hydrogen, the gamma ray dose emitted by the source, and the thermal neutrons captured by hydrogen, nitrogen, and boron [ 51 ]. Each of the components has various biological weighting factors.…”

Section: Fundamental Aspects Of Bnctmentioning

confidence: 99%

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Skwierawska

López-Valverde

Balcerzyk

et al. 2022

Cancers

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Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.

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Section: Fundamental Aspects Of Bnctmentioning

confidence: 99%

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Skwierawska

López-Valverde

Balcerzyk

et al. 2022

Cancers

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“…The components of the effective dose rate of photons and gamma obtained from simulations and calculations are used to obtain the total dose rate in soft tissue. The amount of the total dose rate is obtained by the following equation [19]:…”

Section: Data Analysis Techniquementioning

confidence: 99%

Safety analysis of paraffin wax based biological shielding for cancer therapy with BNCT method on piercing beamport of Kartini nuclear reactor Yogyakarta

Sardjono

Walhikmah

Widiatmono

et al. 2022

J. Phys.: Conf. Ser.

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Cancer is one of the deadly diseases for humans. According to the World Health Organization (WHO) in 2018, there were 9.6 million deaths caused by cancer. Boron Neutron Capture Therapy (BNCT) is a cancer therapy method that is cell targeting by utilizing the reaction of the Boron-10 core with thermal neutrons. The use of BNCT facilities needs attention regarding the safety of radiation workers. An attempt that could be made is to mount a material on a radiation shield that efficiently blocks neutron and gamma radiation. To optimize the calculation used PHITS computer code. The result can be concluded that the characteristics of paraffin wax were effective in blocking neutron radiation but not effective in absorbing gamma radiation. C36H74 is a paraffin wax with the highest density, but produces the lowest dose rate value. The optimum geometry and radiation shielding materials to with stand neutron and gamma radiation are paraffin wax, aluminum and lead with a thickness of 6 cm on top, bottom and front 5 cm, and left and right 3 and a dose rate value at the top of 2.00 µSv/hour, bottom 6.41 µSv/hour, front 5.55 µSv/hour, left and right 3 µSv/hour respectively.

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“…Ionizing radiation has many forms, from alpha, beta, proton, or neutron particles to X or gamma rays and others. In Boron Neutron Capture Therapy, components that contribute to the total absorbed dose rate are due to elastic interaction of incident neutrons with hydrogen, gamma ray's dose emitted by the source, and thermal neutrons captured by hydrogen, nitrogen, and boron [32]. Each of the components has various biological weighting factors.…”

Section: Physical Bases and Fundamental Dosimetric Process Of Bnctmentioning

confidence: 99%

Physical bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action - Critical Overview of the Literature

Skwierawska¹,

Balcerzyk²,

López-Valverde³

et al. 2021

Preprint

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The success of boron neutron capture therapy(BNCT) mainly depends on sufficient spatial bio-distribution of boron(10B) localized around or within the neoplastic cells to produce a high dose gradient between the tumor and healthy tissue. Contrary to what is usual in radiotherapy, BNCT proposes treatment planning directed at the cell instead of the tumor mass. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Some critical issues still need to be resolved if BNCT is to become valuable, minimally invasive, and efficient cancer treatment. This review article provides an overview of fundamental principles, the recent advances, and future directions of BNCT as cellular targeted cancer therapy. The main emphasis is on topics related to biological dosimetry, methods for as-sessment of boron concentration, mechanisms of action of BNCT, and its physical bases for clinical implementation.

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Dose Analysis of BNCT Treatment Method for Rhabdomyosarcoma in the Head and Neck Regions Based on PHITS Code

Cited by 5 publications

References 14 publications

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Safety analysis of paraffin wax based biological shielding for cancer therapy with BNCT method on piercing beamport of Kartini nuclear reactor Yogyakarta

Physical bases of Boron Neutron Capture Therapy, Dosimetry, and Its Mechanisms of Action - Critical Overview of the Literature

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