Dose- and conditioning trial-dependent ethanol-induced conditioned place preference in Swiss-Webster mice

Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference

“…The failure to see temporal summation in the present situation is at odds with the previous observation of summation with two closely spaced ethanol injections when the first injection occurred just before CS exposure and the second injection was given 5 min later (Cunningham et al, 2003b). In that case, magnitude of place preference was enhanced, as would be expected when the CS is paired with a larger ethanol dose (Cunningham et al, 1992;Risinger & Oakes, 1996). Thus, the present findings suggest that temporal summation of rewarding effects does not benefit a CS that is uniquely paired with the second in a series of closely spaced ethanol exposures.…”

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

“…Pairing distinctive environmental cues with ethanol administration results in subsequent CPP Risinger et al 1994;Risinger and Oakes 1996). Place conditioning paradigm has been used for the examination of neuropharmacological mechanisms related to ethanol reward (for a review, see Cunningham et al 2006).…”

Intravenous nicotine conditions a place preference in rats using an unbiased design☆

“…We also sought to begin examining some of the parameters important for acquisition of this nicotine-conditioned place preference: nicotine dose, number of conditioning trials, and temporal relation between chamber exposure and nicotine administration. The number of conditioning trials was expected to be important given that Pavlovian conditioned associations ( [Pavlov, 1927] and [Wilkinson et al, 2006]), including place conditioning ([Brabant et al, 2005] and [Risinger and Oakes, 1996]), vary as a function of number of stimulus pairings. We also expected the temporal arrangement between context (end compartment) exposure and nicotine administration to be an important determinant of conditioning [for research and discussion of this variable (often termed "interstimulus interval") see , Burgos and Bevins (1997), Gibbon et al (1977), and Pavlov (1927)].…”