Dose- and time-dependent changes of micronucleus frequency and gene expression in the progeny of irradiated cells: Two components in radiation-induced genomic instability?

Role of microRNAs and DNA Methyltransferases in Transmitting Induced Genomic Instability between Cell Generations

“…The dioxin model compound 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) is a non-genotoxic carcinogen ( 43 , 44 ) but appears to induce genomic instability ( 8 ). Direct genotoxicity of ionizing radiation and cadmium, lack of direct genotoxicity of TCDD, IGI initiation by ionizing radiation and TCDD, as well as lack of IGI from exposure to cadmium were all shown in our previous experiments with C3H/10T1/2 cells ( 8 , 45 ). In these studies, direct genotoxicity was measured 2 days after exposure, and IGI was assessed by measuring micronuclei at 8 days (and 15 days for radiation) after exposure.…”

Assessment of genotoxicity and genomic instability in rat primary astrocytes exposed to 872 MHz radiofrequency radiation and chemicals

“…These cells divide slowly, which means that a longduration study is needed to assess genomic instability (=delayed genetic changes) in the distant progeny of the exposed cells. Because of the long duration of the study ( instability induced by other agents (Korkalainen et al 2012;Huumonen et al 2014aHuumonen et al , 2014bLuukkonen et al 2014;Kesari et al 2015). It might also be useful to test whether RF radiation enhances genomic instability induced by other agents (e.g.…”

Radiosensitivity in patients suffering from chronic kidney disease

“…Although the term genomic instability is often used just to describe the levels of genetic damage in a defi ned cell (Torres-Bugar í n et al 2014), it is a concept that must be used to describe the fi nding that delayed repair damage is observed in the progeny of irradiated cells (Little 1998, Huumonen et al 2014. In this context genomic instability refl ects the individual ability to respond to genomic insults.…”