Dose- and time-dependent effects of ethanolic extract of Mucuna pruriens Linn. seed on sexual behaviour of normal male rats

Suresh, S.; Prithiviraj, Elumalai; Prakash, Seppan

doi:10.1016/j.jep.2009.01.032

Cited by 93 publications

(78 citation statements)

References 14 publications

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“…However, it was observed in certain dose only, not in all of the dosas gave the effect of significant weight gains. This dosedependent effects could be happen, similar to dose-dependent effects on weight gains when the ethanol extract of Mucuna pruriens seeds administered to diabetic rats [10] and dose and timedependent effects on sexual behavior when the ethanol extract of Mucuna pruriens seeds administered to normal male rats [3].…”

Section: Discussionmentioning

confidence: 76%

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Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Sardjono

Musthapa

Sholihin

et al. 2017

Int J Pharm Pharm Sci

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Objective: This research was conducted to determine the acute toxicity of ethanol extract of velvet beans (Mucuna pruriens) from Indonesia. Extract of Indonesian Mucuna pruriens seeds showed antiparkinson activity due to the presence of L-DOPA inadequate levels. However, research on the toxicity level of Mucuna pruriens seeds from Indonesia is still limited. Acute toxicity data are needed to make Mucuna pruriens as standardized herbal medicine for Parkinson disease. Methods:The dried seed of Mucuna pruriens was extracted by ethanol and suspended with tragacanth to make several dosas of ethanol extract of Mucuna pruriens seeds. Determination of acute toxicity was performed on six groups, each consisting of five Wistar rats. One group was used as a control group; other groups were given ethanol extract of Mucuna pruriens seeds orally at a dose of 5 mg/kg, 50 mg/kg, 300 mg/kg, 2000 mg/kg, and 5000 mg/kg body weight. Symptoms of toxicity, including death, were observed daily for 14 d. At the end of the observation, the surviving Wistar rats were autopsied and the brain, heart, liver, lungs, stomach, spleen, kidneys, and ovaries were weighed to give relative organ weight. Results:There was no mortality observed in all groups. The Wistar rats gained weight within the normal range. The relative organ weights in all groups generally did not show a significant difference. However, the significant differences (P<0.05) were seen in the liver for all treatment groups compared to the control group. Conclusion:The ethanol extract of Mucuna pruriens seeds from Indonesia administered orally has LD50

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Section: Discussionmentioning

confidence: 76%

“…Traditionally, the seed of Mucuna pruriens is used as an aphrodisiac and believed to overcome problems regarding fertility, impotence, spermatorrhea, and sterility [3]. The seed is also used as a diuretic, nerve tonic, anti-inflammatory, and stimulant due to its antidepressant activity, and used in the treatment of Parkinson's disease [4].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Sardjono

Musthapa

Sholihin

et al. 2017

Int J Pharm Pharm Sci

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“…Some of the genera and species listed in this work in in vitro tests showed satisfactory answers to such an aphrodisiac effect like Turnera diffusa (Estrada-Reyes et al, 2009), Pfaffia paniculata (Arletti et al, 1999), Passiflora (Patel et al 2009), Mucuna pruriens (Suresh et al, 2009), Mimosa pudica (Pande & Pathak, 2009), Mimosa tenuiflora (Souza et al, 2008), Achyrocline satureioides (Hnatyszyn et al, 2004;Simões et al, 1986) and Anemopaegma arvense (Chieregatto, 2005).…”

Section: Male Dysfunction Therapiesmentioning

confidence: 72%

Phytochemistry of some Brazilian Plants with Aphrodisiac Activity

Silva¹,

Borges²,

Velozo³

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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“…It has been reported to possess medicinal values and some works indicated the potential use of M. pruriens as alternative source of protein in fish feed (Ignacimuthu et al, 2008, Pugalenthi et al, 2005, Sridhar et al, 2007. The plant has been found to increase libido in men due to its dopaminergic properties (Giuliano et al, 2001, Shukla et al, 2010 intromission and ejaculation, and decreased latencies in normal male rats (Suresh et al, 2009, Suresh et al, 2010. However, no studies have been reported related to its in vivo effect on sex reversal, growth and immunostimulation of fish.…”

Section: Introductionmentioning

confidence: 99%

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Mukherjee¹,

Ghosal²,

Hancz³

et al. 2018

Turk. J. Fish. Aquat. Sci.

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Study was aimed to evaluate the efficacy of Mucuna pruriens seeds and Asparagus racemosus roots for induction of masculinisation in tilapia. Plant materials were extracted with water, ethanol, methanol and successive methanol and mixed sex juveniles of Nile tilapia were subjected to dietary treatment with the extracts at the concentration of 0.1, 0.15 and 0.2 g/kg feed. All treatments produced significantly higher (P<0.05) percentage of males than control. The highest percentage of males (93.79 ± 0.95) was obtained by treatment with methanol extract of M. pruriens seeds at the concentration of 0.2 g/kg feed. ForA. racemosus roots also, the highest percentage of males (92.24 ± 0.13) was obtained with methanol extract at the concentration of 0.2 g/kg feed. Extracts with different solvents of both the plants showed presence of steroid/terpenoid, saponin and flavonoid. The highest percentage of phenol (658 mg of GAE/g dw) and flavonoid (11.72 mg of RE/g dw) content for M. pruriens was found in aqueous extract whereas for A. racemosus in successive (629 mg of GAE/g dw) and ethanolic extracts (22.08 mg of RE/g dw) respectively. The antiradical activity is highest in methanolic extract of Mucuna (18.265%) and ethanolic extract of Asparagus (98.522%).

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Dose- and time-dependent effects of ethanolic extract of Mucuna pruriens Linn. seed on sexual behaviour of normal male rats

Cited by 93 publications

References 14 publications

Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Phytochemistry of some Brazilian Plants with Aphrodisiac Activity

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