Dose considerations for anti-cancer drugs in metastatic prostate cancer

Abstract

Despite a growing number of treatment options, metastatic castrate resistant prostate cancer remains almost universally fatal. Dose individualization ensures patients receive the maximal benefit from each line of treatment potentially leading to improved outcomes, a reduction in quality of life impairment and minimization of premature cessation for avoidable toxicity. Herein, we review drug-specific issues that may be associated with unexpected or unrecognized variations in drug systemic exposure despite the use of protocol doses. In particular, we discuss the potential for under-exposure of docetaxel and cabazitaxel; over-exposure of enzalutamide; and varied absorption of abiraterone acetate.

Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment

“…Non-steroidal inhibitors have an inherent advantage over steroidal compounds in this regard. For instance, abiraterone, the only approved CYP17A1 inhibitor in clinical use, should be taken as a flat dose of 1000 mg administered on an empty stomach . This relatively high dose reflects poor absorption but also a very high fraction of the drug bound to the plasma proteins .…”

“…For instance, abiraterone, the only approved CYP17A1 inhibitor in clinical use, should be taken as a flat dose of 1000 mg administered on an empty stomach. 187 This relatively high dose reflects poor absorption but also a very high fraction of the drug bound to the plasma proteins. 188 The non-steroidal scaffold offers potentially greater flexibility in fine-tuning physicochemical properties.…”

An Evaluation Approach of Cell Viability Based on Cell Detachment Assay in a Single-Channel Integrated Microfluidic Chip

“…Cell viability assessment is significantly important for dosage tests of anticancer drugs, − cell toxicology studies, − and other biochemical stimulations. , During treatment of a tumor with anticancer drugs, some cancer cells sensitive to drugs are killed and other cancer cells of strong viability survive and grow, finally causing treatment failure . However, excess dosage of drugs will do harm to normal cells, so it is important for the proper dosage of drugs to accurately improve cell viability assessment .…”