Dose-Dependence of Fast Neutron RBE for Lens Opacification in Mice

Micronucleus Induction inVicia FabaRoots

“…A good correspondence is found between the data obtained for the induction of micronuclei in bean roots and that of lens opacification in mice, determined after irradiation in the same high-energy neutron beam. Furthermore, the present data give an RBE dependence on dose which is very close to that reported in the literature for the induction of chromosome aberrations in Tra.desoantia stamen hairs (Sparrow et al 1972), lens opacification in mice (Bateman et al 1972), induction of mammary tumours in rats (Vogel 1969), chromosome aberrations in human lymphocytes (Biola et al 1971), growth reduction in Vioia faha (Hall et al 1973), and skin damage in humans, rats, and pigs (Field 1969). However, some caution has to be taken when making a comparison with data reported in the literature; in fact in some of the curves shown in figure 6, X-rays have been used as the reference radiation instead of y-rays.…”

Physical aspects of radiation sensitivity

“…The microdosimetric analysis is in substantial agreement with a wide range of experimental obser vations, and it has led to the prediction of un expectedly high RBE values of neutrons at low doses that have recently been verified for lens opacification, 1 for somatic mutations in plants 22 , and for radiation induced tumours 20 21 .…”

Comparison of the Induction of Pulmonary Neoplasms in Sprague-Dawley Rats by Fission Neutrons and Radon Daughters

“…Animal studies have therefore gained added importance. The findings of large neutron RBEs at low doses [see, for example, (14)(15)(16)(17)(18)(19)] have motivated proposals to increase the quality factors for neutrons in radiation protection (20).…”