Dose-dependent changes in cognitive function with exercise augmentation for major depression: Results from the TREAD study

Greer, Tracy L.; Grannemann, Bruce D.; Chansard, Matthieu; Karim, Alyzae I.; Trivedi, Madhukar H.

doi:10.1016/j.euroneuro.2014.10.001

Cited by 62 publications

(52 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given that psychosocial impairment following treatment is associated with an increased risk of recurrence of depression, our finding that psychosocial improvements can be realized even with low‐dose exercise is promising. Added to our previous findings in this sample suggesting that exercise decreases depressive symptoms and improves self‐reported sleep quality and cognitive function, this research would suggest that exercise augmentation is likely to improve long‐term treatment outcomes by reducing several risk factors for depression recurrence.…”

Section: Discussionmentioning

confidence: 75%

Improvements in Psychosocial Functioning and Health-Related Quality of Life Following Exercise Augmentation in Patients With Treatment Response but Nonremitted Major Depressive Disorder: Results From the Tread Study

et al. 2016

Self Cite

View full text Add to dashboard Cite

BACKGROUND Functional impairments often remain despite symptomatic improvement with antidepressant treatment, supporting the need for novel treatment approaches. The present study examined the extent to which exercise augmentation improved several domains of psychosocial functioning and quality of life among depressed participants. METHODS Data were collected from 122 partial responders to antidepressant medication. Participants were randomized to either high (16 kilocalories per kilogram of weight per week [KKW]) or low dose (4KKW) exercise. Participants completed a combination of supervised and home-based exercise for 12 weeks. The Short-Form Health Survey, Work and Social Adjustment Scale, Social Adjustment Scale, the Quality of Life Enjoyment and Satisfaction Questionnaire, and the Satisfaction with Life Scale were collected at 6 and 12 weeks. Participants with data for at least one of the two follow-up time points (n=106) were analyzed using a linear mixed model to assess change from baseline within groups and the difference between groups for each psychosocial outcome measure. All analyses controlled for covariates, including baseline depressive symptomatology. RESULTS Participants experienced significant improvements in functioning across tested domains, and generally fell within a healthy range of functioning on all measures at Weeks 6 and 12. While no differences were found between exercise groups, improvements were observed across a variety of psychosocial and quality-of-life domains, even in the low exercise dose group. CONCLUSIONS These findings support exercise augmentation of antidepressant treatment as a viable intervention for treatment-resistant depression to improve function in addition to symptoms.

show abstract

Section: Discussionmentioning

confidence: 75%

Improvements in Psychosocial Functioning and Health-Related Quality of Life Following Exercise Augmentation in Patients With Treatment Response but Nonremitted Major Depressive Disorder: Results From the Tread Study

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…The fact that this finding was significant only for the clinician rated QIDS may reflect an interaction between poor cognitive function and overall self-reported symptoms; although this is essentially speculative. A sub-sample of the TREAD study was tested more thoroughly with a cognitive battery (Greer et al, 2015) and it was found that high dose exercise was more effective in improving cognition in TREAD subjects than low dose across the range of tests, although performance in some cognitive areas improved in all subjects regardless of treatment assignment. However, Greer et al found that change in cognitive performance did not correlate with change in overall depression severity.…”

Section: Discussionmentioning

confidence: 99%

Exercise is an effective treatment for positive valence symptoms in major depression

Toups

Carmody

Greer

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

Introduction Measurement of symptoms domains and their response to treatment in relative isolation from diagnosed mental disorders has gained new urgency, as reflected by the National Institute of Mental Health’s introduction of the Research Domain Criteria (RDoC). The Snaith Hamilton Pleasure Scale (SHAPS) and the Motivation and Energy Inventory (MEI) are two scales measuring positive valence symptoms. We evaluated the effect of exercise on positive valence symptoms of Major Depressive Disorder (MDD). Methods Subjects in the Treatment with Exercise Augmentation for Depression (TREAD) study completed self-reported SHAPS and MEI during 12 weeks of exercise augmentation for depression. We evaluated the effect of exercise on SHAPS and MEI scores, and whether the changes were related to overall MDD severity measured with the Quick Inventory of Depression Symptomatology (QIDS). Results SHAPS and MEI scores significantly improved with exercise. MEI score change had larger effect size and greater correlation with change in QIDS score. MEI also showed significant moderator and mediator effects of exercise in MDD. Limitations Generalizability to other treatments is limited. This study lacked other bio-behavioral markers that would enhance understanding of the relationship of RDoC and the measures used. Conclusions Positive valence symptoms improve with exercise treatment for depression, and this change correlates well with overall outcome. Motivation and energy may be more clinically relevant to outcome of exercise treatment than anhedonia.

show abstract

“…Evidence suggests exercise has modest effects on aspects of cognitive performance, including attention, processing speed, memory, and executive functioning [40]. While there is emerging evidence of a dose-response relationship between exercise and cognition [41], even low doses of exercise appear to provide attention and visuospatial benefits for both healthy and depressed older adults [42, 43]. For example, improvements in attention and inhibitory control but not working memory have been found following a single, moderate intensity (65–75% of estimated maximal heart rate) exercise session [43].…”

Section: Exercise To Improve Cognitive Functionmentioning

confidence: 99%

“…For example, improvements in attention and inhibitory control but not working memory have been found following a single, moderate intensity (65–75% of estimated maximal heart rate) exercise session [43]. Subsequent analysis of data from a large study of exercise for depression found that individuals with MDD who received a public health guideline concordant dosage of exercise (equivalent to 30 min of moderate intensity aerobic exercise, five or more days per week) had improved psychomotor speed, attention, visual memory, and spatial planning at 12-week follow-up [41]. …”

Section: Exercise To Improve Cognitive Functionmentioning

confidence: 99%

The Roles of Exercise and Yoga in Ameliorating Depression as a Risk Factor for Cognitive Decline

Mathersul

Rosenbaum

2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Currently, there are no effective pharmaceutical treatments to reduce cognitive decline or prevent dementia. At the same time, the global population is aging, and rates of dementia and mild cognitive impairment (MCI) are on the rise. As such, there is an increasing interest in complementary and alternative interventions to treat or reduce the risk of cognitive decline. Depression is one potentially modifiable risk factor for cognitive decline and dementia. Notably, exercise and yoga are two interventions known to both reduce symptoms of depression and improve cognitive function. The current review discusses the efficacy of exercise and yoga to ameliorate depression and thereby reduce the risk of cognitive decline and potentially prevent dementia. Potential mechanisms of change, treatment implications, and future directions are discussed.

show abstract

Dose-dependent changes in cognitive function with exercise augmentation for major depression: Results from the TREAD study

Cited by 62 publications

References 31 publications

Improvements in Psychosocial Functioning and Health-Related Quality of Life Following Exercise Augmentation in Patients With Treatment Response but Nonremitted Major Depressive Disorder: Results From the Tread Study

Improvements in Psychosocial Functioning and Health-Related Quality of Life Following Exercise Augmentation in Patients With Treatment Response but Nonremitted Major Depressive Disorder: Results From the Tread Study

Exercise is an effective treatment for positive valence symptoms in major depression

The Roles of Exercise and Yoga in Ameliorating Depression as a Risk Factor for Cognitive Decline

Contact Info

Product

Resources

About