Dose‐dependent control of intragastric pH by pantoprazole, 10, 20 or 40 mg, in healthy volunteers

Abstract

Background: Proton pump inhibitors have emerged as the most effective class of drugs for the treatment of gastro‐oesophageal reflux. Pantoprazole is a proton pump inhibitor that has demonstrated high clinical efficacy. Aim: To evaluate the effect of once‐daily doses of pantoprazole, 10, 20 and 40 mg, on gastric acidity in healthy volunteers. Methods: Thirty‐six subjects received pantoprazole in a three‐way crossover design study. Ambulatory 24‐h intragastric pH and distal oesophageal pH were monitored at baseline and on the last day of each treatment period. The measured endpoints were the median intragastric and oesophageal pH, the percentage of time the intragastric pH < 4 and oesophageal pH < 4 and the area under the curve for gastric acidity over 24 h. Safety was evaluated by incidence and severity of adverse events. Results: Pantoprazole demonstrated a linear dose‐ dependent suppression of gastric acidity over the dose range 10–40 mg. The dose of 40 mg demonstrated a significantly greater response than the lower doses, particularly at night. All pantoprazole doses were well tolerated. Conclusions: Pantoprazole demonstrates a dose‐related effect in the range 10–40 mg once daily. The once‐daily dose of 40 mg provides the highest and most consistent control of gastric pH, especially at night.

Proton Pump Inhibitor Co-medication Reduces Mycophenolate Acid Drug Exposure in Heart Transplant Recipients

“…Tutuian et al demonstrated that pantoprazole 40 mg once daily provides a linear, dose-dependent suppression of gastric acidity, with a median intragastric pH of 4.02 in 24 hours. 25 A recent study by Somberg et al showed that pantoprazole provides a mean gastric pH of 4.43 in intensive care unit patients in 24 hours. 26 We included patients in the early phase after HTx, but also patients in the late phase of HTx in order to minimize the limitations of the different therapeutic regimens.…”

A Porcine Model of Acute Lung Injury by Instillation of Gastric Fluid

“…This volume was chosen based upon the study by the Zurich group [8] and on preliminary experiments with other doses (data not shown). A pH value of 2.0 was used to reflect physiological value for GJ [23]. We preferred GJ instead of HCl/pepsin mixture as it is thought that bile acids and pepsin may also play a role in inducing airway inflammation [24].…”

The proton pump inhibitor pantoprazole and its interaction with enteric-coated mycophenolate sodium in transplant recipients

“…15 Therefore, PPIs have emerged as the most effective class of drugs for the treatment of gastroesophageal reflux disease, as well as several other acid-related disorders. 16 All PPIs inhibit gastric acid secretion through binding with H ϩ /K ϩ -adenosine triphosphatase in gastric parietal cells and thereby they can modify the intragastric release of other drugs by elevating the pH value. For pantoprazole, lansoprazole and omeprazole, this binding is irreversible, whereas rabeprazole exhibits reversible binding to the proton pump.…”