Dose-dependent Differential Mechanism of Quercetin-induced
Vasodilatations in Isolated Perfused Rat Mesenteric Vascular Bed

Özü, Özlem Yorulmaz; Ertuğ, Fatma; Karabulut, Ercan; Kumcu, Eda Karabal; Şingirik, Ergin; Seçilmiş, Mehmet Ata

doi:10.3923/ijp.2016.379.386

Cited by 2 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is in agreement with those of previous studies that demonstrated the vasodilatory effects of kaempferol in different vascular beds [55][56][57][58] . Similar findings have also been reported on the vasorelaxant properties of other flavonoids such as quercetin, myricetin, rutin and apigenin 57,59 . Kaempferol, however, is considered as the most effective among all flavonoids in potentiating vasorelaxation, thus might have more significant potential in preventing and treating CVDs 57 .…”

Section: Discussionsupporting

confidence: 88%

Anti-hypertensive vasodilatory action of Gynura procumbens mediated by kaempferol 3-O-rutinoside

et al. 2020

View full text Add to dashboard Cite

Introduction: Gynura procumbens (GP), otherwise known as longevity spinach or “Sambung Nyawa” in Malay, is an evergreen herb found in Africa and Southeast Asian countries (including Brunei) used traditionally to treat various diseases such as fever, diabetes and hypertension. We examined GP’s vasodilatory action to determine its possible role via the cholinergic-mediated pathway. Methods: GP leaves were prepared by filtration and evaporation to obtain the aqueous (AEGP) and methanol (MEGP) extracts followed by screening for phytochemical constituents. The total phenol, total flavonoid and flavonol contents were determined using the corresponding Folin–Ciocalteau, and aluminium colorimetric methods and the presence of kaempferol 3-O-rutinoside in the extracts was detected using HPLC analysis. Organ bath studies were conducted to determine the vasodilatory activity using intact and denuded isolated rat aortic rings by exposure to either increasing concentration of extracts (0.25, 0.5, 1.0, and 2.0 mg/mL) or 10 µg/mL kaempferol 3-O-rutinoside in the presence or absence of acetylcholine (ACh) after pre-contraction by noradrenaline (NA). Results: MEGP contained more phytochemical constituents and higher content of total flavonoid and total flavonol but less phenolic content than AEGP. Furthermore, MEGP yielded a 20% elevated amount of kaempferol 3-O-rutinoside than AEGP. Both extracts significantly amplified ACh-endothelium dependent vasodilation and mediated relaxation at 1 mg/mL in endothelium-intact and endothelium-denuded aortic rings with MEGP as a more effective vasodilator than AEGP. Overall, these results imply the involvement of extracts in potentiating cholinergic pathway, which might be mediated by kaempferol, as shown by its vasorelaxation effects in endothelium-intact and –denuded aorta. Conclusions: The present findings demonstrate that the vasodilatory activities of the two Gynura procumbens extracts, AEGP and MEGP, in thoracic aorta rings isolated from rats are potentially mediated via a cholinergic pathway through the action of a flavonoid particularly kaempferol 3-O-rutinoside.

show abstract

Section: Discussionsupporting

confidence: 88%

Anti-hypertensive vasodilatory action of Gynura procumbens mediated by kaempferol 3-O-rutinoside

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In addition, quercetin was shown to induce vasodilation by enhancing NO synthesis and promoting intracellular calcium-activated potassium channels [164]. Quercetin exerted endothelium-dependent vasodilatations via invoking sustained nitric oxide release in mesenteric vascular beds isolated from rats [165]. Quercetin also restored the intravascular homeostasis and endothelial functions, by attenuating excess NO production induced by ATP, decreased intracellular calcium flux, and eNOS activity in vascular endothelial cells [166].…”

Section: Potential Combinatory Roles For Citrulline and Quercetin In Gastrointestinal Health Of Animalsmentioning

confidence: 99%

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and homeostasis is imminent. Recent studies have uncovered the beneficial effects of dietary supplements on the immune response, microbiota, gut homeostasis, and intestinal health. The application of citrulline (a functional gut biomarker) and quercetin (a known potent flavonoid) to promote gut functions has gained considerable interest as both bioactive substances possess anti-inflammatory, anti-oxidative, and immunomodulatory properties. Research has demonstrated that both citrulline and quercetin can mediate gut activities by combating disruptions to the intestinal integrity and alterations to the gut microbiota. In addition, citrulline and quercetin play crucial roles in maintaining intestinal immune tolerance and gut health. However, the synergistic benefits which these dietary supplements (citrulline and quercetin) may afford to simultaneously promote gut functions remain to be explored. Therefore, this review summarizes the modulatory effects of citrulline and quercetin on the intestinal integrity and gut microbiota, and further expounds on their potential synergistic roles to attenuate intestinal inflammation and promote gut health.

show abstract

Dose-dependent Differential Mechanism of Quercetin-induced Vasodilatations in Isolated Perfused Rat Mesenteric Vascular Bed

Cited by 2 publications

References 35 publications

Anti-hypertensive vasodilatory action of Gynura procumbens mediated by kaempferol 3-O-rutinoside

Anti-hypertensive vasodilatory action of Gynura procumbens mediated by kaempferol 3-O-rutinoside

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Contact Info

Product

Resources

About