Dose dependent dopaminergic modulation of reward-based learning in Parkinson's disease

Wouwe, Nelleke C. van; Ridderinkhof, K. Richard; Band, Guido P. H.; Wildenberg, Wery P. M. van den; Wylie, Scott A.

doi:10.1016/j.neuropsychologia.2011.12.012

Cited by 16 publications

(20 citation statements)

References 61 publications

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“…Thus, although we cannot delineate the exact contribution of altered dopaminergic tone to the FRN, our results strongly suggest that any impairment in dopaminergic modulation, both under and over activation, would likely result in inadequate expectation signaling and thus the FRN response found here. Future studies may address this issue using drug-naive patients, although previous studies have indicated little effect of medication on reward tasks [ 42 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study

et al. 2015

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The proper functioning of the mesolimbic reward system is largely dependent on the neurotransmitter dopamine. Recent evidence suggests that the hypocretin system has significant projections to this reward system. We examined the distinct effects of reduced dopamine or reduced hypocretin levels on reward activity in patients with Parkinson’s disease, dopamine deficient, as well as patients with narcolepsy-cataplexy, hypocretin depleted, and healthy controls. Participants performed a simple game-like task while high-density electroencephalography was recorded. Topography and timing of event-related potentials for both reward cue, and reward feedback was examined across the entire dataset. While response to reward cue was similar in all groups, two distinct time points were found to distinguish patients and controls for reward feedback. Around 160ms both patient groups had reduced ERP amplitude compared to controls. Later at 250ms, both patient groups also showed a clear event-related potential (ERP), which was absent in controls. The initial differences show that both patient groups show a similar, blunted response to reward delivery. The second potential corresponds to the classic feedback-related negativity (FRN) potential which relies on dopamine activity and reflects reward prediction-error signaling. In particular the mismatch between predicted reward and reward subsequently received was significantly higher in PD compared to NC, independent of reward magnitude and valence. The intermediate FRN response in NC highlights the contribution of hypocretin in reward processing, yet also shows that this is not as detrimental to the reward system as in Parkinson’s. Furthermore, the inability to generate accurate predictions in NC may explain why hypocretin deficiency mediates cataplexy triggered by both positive and negative emotions.

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Section: Discussionmentioning

confidence: 99%

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study

et al. 2015

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“…In many reinforcement learning paradigms, only overt actions are associated to reward or punishment outcomes (i.e., instrumental learning) (Frank, Seeberger & O'Reilly, 2004; O'Doherty, 2004; van Wouwe, Ridderinkhof, Band, van den Wildenberg & Wylie, 2012). However, in many situations, refraining from action is necessary for reward acquisition and punishment avoidance.…”

Section: Introductionmentioning

confidence: 99%

Easy to learn, hard to suppress: The impact of learned stimulus–outcome associations on subsequent action control

Wouwe

Wildenberg

Ridderinkhof

et al. 2015

Brain and Cognition

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The inhibition of impulsive response tendencies that conflict with goal-directed action is a key component of executive control. An emerging literature reveals that the proficiency of inhibitory control is modulated by expected or unexpected opportunities to earn reward or avoid punishment. However, less is known about how inhibitory control is impacted by the processing of task-irrelevant stimulus information that has been associated previously with particular outcomes (reward or punishment) or response tendencies (action or inaction). We hypothesized that stimulus features associated with particular action-valence tendencies, even though task irrelevant, would modulate inhibitory control processes. Participants first learned associations between stimulus features (color), actions, and outcomes using an action-valence learning task that orthogonalizes action (action, inaction) and valence (reward, punishment). Next, these stimulus features were embedded in a Simon task as a task-irrelevant stimulus attribute. We analyzed the effects of action-valence associations on the Simon task by means of distributional analysis to reveal the temporal dynamics. Learning patterns replicated previously reported biases; inherent, Pavlovian-like mappings (action-reward, inaction-punishment avoidance) were easier to learn than mappings conflicting with these biases (action-punishment avoidance, inaction-reward). More importantly, results from two experiments demonstrated that the easier to learn, Pavlovian-like action-valence associations interfered with the proficiency of inhibiting impulsive actions in the Simon task. Processing conflicting associations led to more proficient inhibitory control of impulsive actions, similar to Simon trials without any association. Fast impulsive errors were reduced for trials associated with punishment in comparison to reward trials or trials without any valence association. These findings provide insight into the temporal dynamics of task irrelevant information associated with action and valence modulating cognitive control. We discuss putative mechanisms that might explain these interactions.

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“…Further, in order to maximize learning, is crucial the ability to associate stimuli with actions that lead to rewarding outcomes (van Wouwe et al, 2012 ). Therefore, in the following sections, we will explore the impact of DRT on learning and reward.…”

Section: Rehabilitation In Pd: Key Points For Effectivenessmentioning

confidence: 99%

“…Although the basal ganglia are traditionally known to contribute to motor function, more recently they have been shown to be engaged in several types of learning, including habit formation, procedural skill learning, and reward-based decision-learning (van Wouwe et al, 2012 ). Therefore, involving the disruption of basal ganglia, PD provides an informative naturalistic model for understanding the role of dopamine in reward and learning.…”

Section: The Impact Of Drt On Learning and Rewardmentioning

confidence: 99%

Dopamine Replacement Therapy, Learning and Reward Prediction in Parkinson’s Disease: Implications for Rehabilitation

Ferrazzoli

Carter

Ustun

et al. 2016

Front. Behav. Neurosci.

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The principal feature of Parkinson’s disease (PD) is the impaired ability to acquire and express habitual-automatic actions due to the loss of dopamine in the dorsolateral striatum, the region of the basal ganglia associated with the control of habitual behavior. Dopamine replacement therapy (DRT) compensates for the lack of dopamine, representing the standard treatment for different motor symptoms of PD (such as rigidity, bradykinesia and resting tremor). On the other hand, rehabilitation treatments, exploiting the use of cognitive strategies, feedbacks and external cues, permit to “learn to bypass” the defective basal ganglia (using the dorsolateral area of the prefrontal cortex) allowing the patients to perform correct movements under executive-volitional control. Therefore, DRT and rehabilitation seem to be two complementary and synergistic approaches. Learning and reward are central in rehabilitation: both of these mechanisms are the basis for the success of any rehabilitative treatment. Anyway, it is known that “learning resources” and reward could be negatively influenced from dopaminergic drugs. Furthermore, DRT causes different well-known complications: among these, dyskinesias, motor fluctuations, and dopamine dysregulation syndrome (DDS) are intimately linked with the alteration in the learning and reward mechanisms and could impact seriously on the rehabilitative outcomes. These considerations highlight the need for careful titration of DRT to produce the desired improvement in motor symptoms while minimizing the associated detrimental effects. This is important in order to maximize the motor re-learning based on repetition, reward and practice during rehabilitation. In this scenario, we review the knowledge concerning the interactions between DRT, learning and reward, examine the most impactful DRT side effects and provide suggestions for optimizing rehabilitation in PD.

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Dose dependent dopaminergic modulation of reward-based learning in Parkinson's disease

Cited by 16 publications

References 61 publications

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study

The Roles of Dopamine and Hypocretin in Reward: A Electroencephalographic Study

Easy to learn, hard to suppress: The impact of learned stimulus–outcome associations on subsequent action control

Dopamine Replacement Therapy, Learning and Reward Prediction in Parkinson’s Disease: Implications for Rehabilitation

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