2000
DOI: 10.1016/s0378-5955(00)00059-9
|View full text |Cite
|
Sign up to set email alerts
|

Dose-dependent effect of 8-day cisplatin administration upon the morphology of the albino guinea pig cochlea

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

10
65
3
3

Year Published

2003
2003
2015
2015

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 79 publications
(81 citation statements)
references
References 25 publications
10
65
3
3
Order By: Relevance
“…Confirming observations by Cardinaal et al 12 , this study showed that cisplatin induces dose-dependent cochlear alterations. High drug dosages in short periods of time (8mg/kg/day, three days) led to cellular lesions and significant hair damage in outer hair cells.…”
Section: Discussionsupporting
confidence: 91%
See 3 more Smart Citations
“…Confirming observations by Cardinaal et al 12 , this study showed that cisplatin induces dose-dependent cochlear alterations. High drug dosages in short periods of time (8mg/kg/day, three days) led to cellular lesions and significant hair damage in outer hair cells.…”
Section: Discussionsupporting
confidence: 91%
“…Concomitant use of cisplatin and Hyperbaric Oxygen Therapy is contra-indicated but in this case cisplatin was used as an efficient lesion producer in cochlea outer hair cells in a short time 12 and the hyperbaric therapy only started 48 hours after the last drug dose.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Alguns autores sugerem a ocorrência de um bloqueio na transdução dos canais de cálcio destas células, outros estudos mostram lesões às células ciliadas internas, às células suportes e "stria vascularis", bem como o gânglio espiral. [10][11][12][13][14][15][16][17] A cisplatina causa uma perda auditiva bilateral e irreversível em humanos, com zumbido associado e comprometendo as altas freqüências (4.000 Hz a 8.000 Hz). 1,2,4,8,18 As formas de se estudar os efeitos da toxicidade coclear têm se dirigido às alterações eletrofisiológicas detectadas pelo Potencial Evocado de Tronco Cerebral (BERA) e Potencial Endococlear.…”
Section: Introductionunclassified