Dose-dependent effect of radiation on resorbable blast material titanium implants: an experimental study in rabbits

Doğan, Gülnihal Emrem; Halıcı, Zekai; Karakuş, Emre; Erdemci, Burak; Alsaran, Akgün; Çınar, İrfan

doi:10.1080/00016357.2017.1392601

Cited by 5 publications

(10 citation statements)

References 36 publications

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“…The single dose of 30 Gy radiation was also used in a rabbit study that demonstrated a low volume of newly formed bone between the labels, which suggested that the rate of bone formation is slow. 11,12 The micro-CT results involved three microstructural parameters that are complementary and used to qualify cortical bone integrity and quality. The decrease in bone mass found in the irradiated groups of bone tissue both close and distant to the implant may have occurred due to the impairment of vascularization and osteoblast activity.…”

Section: Discussionmentioning

confidence: 99%

“…Both hind legs of each rabbit were subjected to irradiation using a single dose of 30 Gy. 11 , 12 , 17 A 5-mm bolus was given to ensure full build-up. The tibia metaphysis region of the hind leg was the designated zone for irradiation.…”

Section: Methodsmentioning

confidence: 99%

“…1,4,6,7 The stability of titanium implants in the osseointegration process is compromised by radiation in a dose-dependent manner. 11,12 Additionally, there is no consensus regarding the impact of ionizing irradiation on the functionality or survival of the implant installed in the irradiation field. Notably, the effect of ionizing radiation is dose dependent.…”

Section: Introductionmentioning

confidence: 99%

“…Gy has been demonstrated to be sufficient to cause a negative influence on bone/implant integrity in a rabbit study model. 11,12 Radiotherapy is one of the most common treatments for head and neck cancer patients, 4,13 and ionizing radiation can reduce bone healing capacity through the progressive fibrosis of blood vessels and soft tissue, 14 loss of osteoblast function 15 and damage to the collagen arrangement. 16 These effects can also negatively influence bone/implant integration.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the effect of ionizing radiation is dose dependent. 11 , 12 A single dose of 30 Gy has been demonstrated to be sufficient to cause a negative influence on bone/implant integrity in a rabbit study model. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

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Biomechanical and morphological changes produced by ionizing radiation on bone tissue surrounding dental implant

Soares

Limirio

et al. 2020

J. Appl. Oral Sci.

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Biomechanical and morphological changes produced by ionizing radiation on bone tissue surrounding dental implant Objective: This study analyzed the effect of ionizing radiation on bone microarchitecture and biomechanical properties in the bone tissue surrounding a dental implant. Methodology: Twenty rabbits received three dental morse taper junction implants: one in the left tibia and two in the right tibia. The animals were randomized into two groups: the nonirradiated group (control group) and the irradiated group, which received 30 Gy in a single dose 2 weeks after the implant procedure. Four weeks after the implant procedure, the animals were sacrificed, and the implant/bone specimens were used for each experiment. The specimens (n=10) of the right tibia were examined by microcomputed tomography to measure the cortical volume (CtV, mm 3), cortical thickness (CtTh, mm) and porosity (CtPo, %). The other specimens (n=10) were examined by dynamic indentation to measure the elastic modulus (E, GPa) and Vickers hardness (VHN, N/mm 2) in the bone. The specimens of the left tibia (n=10) were subjected to pull-out tests to calculate the failure load (N), displacement (mm) up to the failure point and interface stiffness (N/mm). In the irradiated group, two measurements were performed: close, at 1 mm surrounding the implant surface, and distant, at 2.5 mm from the external limit of the first measurement. Data were analyzed using one-way ANOVA, Tukey's test and Student's t-test (α=0.05). Results: The irradiated bone closer to the implant surface had lower elastic modulus (E), Vickers hardness (VHN), Ct.Th, and Ct.V values and a higher Ct.Po value than the bone distant to the implant (P<0.04). The irradiated bone that was distant from the implant surface had lower E, VHN, and Ct.Th values and a higher Ct.Po value than the nonirradiated bone (P<0.04). The nonirradiated bone had higher failure loads, displacements and stiffness values than the irradiated bone (P<0.02). Conclusion: Ionizing radiation in dental implants resulted in negative effects on the microarchitecture and biomechanical properties of bone tissue, mainly near the surface of the implant.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomechanical and morphological changes produced by ionizing radiation on bone tissue surrounding dental implant

Soares

Limirio

et al. 2020

J. Appl. Oral Sci.

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Automatic Segmentation of Bone Canals in Histological Images

et al. 2021

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Avaliação Do Conhecimento E Conduta De Professores Em Casos De Avulsão Dentária Antes E Após Atividades De Capacitação

Gomes¹,

Chaves²,

Simonton³

et al. 2020

Tecnologias Aplicadas À Prática E Ao Ensino Da Odontologia

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Dose-dependent effect of radiation on resorbable blast material titanium implants: an experimental study in rabbits

Abstract: Radiotherapy with 15 and 30 Gy doses can adversely affect osseointegration of implants by reducing the quality of bone and impairing the bone-to-implant contact. The mechanism of action seems to be related to alterations in Bmp-2 and Fgf-2 mRNA expressions.

Cited by 5 publications

References 36 publications

Biomechanical and morphological changes produced by ionizing radiation on bone tissue surrounding dental implant

Biomechanical and morphological changes produced by ionizing radiation on bone tissue surrounding dental implant

Automatic Segmentation of Bone Canals in Histological Images

Avaliação Do Conhecimento E Conduta De Professores Em Casos De Avulsão Dentária Antes E Após Atividades De Capacitação

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