Dose-dependent effect of the pulsed Nd:YAG laser in the treatment of crushed sciatic nerve in Wister rats: an experimental model

Alayat, Mohamed Salaheldien Mohamed; BaSalamah, Mohammad A.; Elbarrany, Wagih G; ElSawy, Naser A.; Abdel-Kafy, Ehab Mohamed; Fiky, Amir Abdel Raouf El

doi:10.1007/s10103-020-02999-z

Cited by 7 publications

(6 citation statements)

References 52 publications

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“…The present study showed a significant decrease in SFI value and an increase in values of the electrophysiological and morphological measures in the MLS group compared to the corresponding values in the control group. This result was consistent with those of previous studies that found that laser to be effective in accelerating the regeneration of crushed sciatic nerves in Wistar rats 4,5,11,16,[20][21][22][23][24][25][26][27][28][29] . Laser therapy increases adenosine triphosphate production, nerve metabolism, and myelin production, and enhances axonal sprouting, thereby increasing the proliferation of the nerves after crushing 1,7) .…”

Section: Discussionsupporting

confidence: 93%

“…The present experimental protocol was approved by the research committee in the Faculty of Applied Medical Science, Umm Al-Qura University, Saudi Arabia with local registration number (12-MED-2958-10). The estimated sample size was calculated using the Gpower 3.1 for windows, with repeated analysis of variance, an effect size of 0.20, an alpha error of 0.05, and a power of 0.95, for three groups and five repeated measures 5,[14][15][16] . The total sample size was 60 rats divided into three groups of 20 rats each.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of multi-wave locked system laser therapy on nerve regeneration after crushing in Wister rats

et al. 2021

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To investigate the efficacy of the multi-wave locked system laser therapy on the regeneration of peripheral nerve injuries by evaluating the functional, electrophysiological, and morphological changes of the crushed sciatic nerve in Wistar rats. [Materials and Methods] Sixty male Wistar rats (200-250 g) were randomly assigned to control negative, control positive, or laser groups and subjected to no laser therapy or crushing, to crushing without laser therapy, or crushing followed by multi-wave locked system laser therapy five times/week for four weeks (power=1 W, energy density=10 J/cm 2 , total energy=100 J), respectively. Functional, electrophysiological, and morphometric analyses were performed before and 7, 15, 21, and 28 days after crushing. The sciatic functional index, compound motor action potential amplitude, motor nerve conduction velocity, and nerve and myelin sheath diameters were measured.[Results] The sciatic functional index value decreased significantly, while the compound motor action potential amplitude, motor nerve conduction velocity, nerve diameter, and myelin sheath diameter increased significantly in the laser group post-treatment compared to the values in the control groups. [Conclusion] Multi-wave locked system laser therapy was effective in accelerating the regeneration of crushed sciatic nerves in Wistar rats.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Efficacy of multi-wave locked system laser therapy on nerve regeneration after crushing in Wister rats

et al. 2021

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“…Our results corroborate many studies [39][40][41][42][43][44][45][46] that report an improvement in gait after the application of LLLT in crush injury of the sciatic nerve. However, different parameters were used concerning the wavelength (660, 685, 808, 830, and 1064 nm) and mainly the energy density (3,4,10,35,40,50,70,80,133,140, and 280 J/cm 2 ).…”

Section: Discussionsupporting

confidence: 91%

Effects of Low-Level Laser Therapy and Purified Natural Latex (Hevea brasiliensis) Protein on Injured Sciatic Nerve in Rodents: Morpho-Functional Analysis

Dias,

Cury,

Dias

et al. 2023

IJMS

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The present study analyzed the effects of low-level laser therapy (LLLT) and the purified natural latex protein (Hevea brasiliensis, F1 protein) on the morpho-function of sciatic nerve crush injuries in rats. One-hundred and eight male Wistar rats were randomly allocated to six groups (n = 18): 1. Control; 2. Exposed (nerve exposed); 3. Injury (injured nerve without treatment); 4. LLLT (injured nerve irradiated with LLLT (15 J/cm2, 780 nm)); 5. F1 (injured nerve treated with F1 protein (0.1%)); and 6. LLLT + F1 (injured nerve treated with LLLT and F1). On the 1st, 7th, 14th, and 56th days after injury, a functional sensory analysis of mechanical allodynia and mechanical hyperalgesia and a motor analysis of grip strength and gait were performed. After 3, 15, and 57 days, the animals were euthanized for morphometric/ultrastructural analyses. The treatments applied revealed improvements in morphometric/ultrastructural parameters compared to the injured group. Sensory analyses suggested that the improvements observed were associated with time progression and not influenced by the treatments. Motor analyses revealed significant improvements in grip strength from the 7th day in the LLLT group and in gait from the 56th day in all treated groups. We concluded that even though the morphological analyses showed improvements with the treatments, they did not influence sensory recovery, and LLLT improved motor recovery.

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“…Although the biomolecular and cellular PBM activities have not been entirely determined, there were three perspectives referring to different stages how LLLT alleviates DH. First, LLLT may immediately change patients' self-perception by modulating neuronal physiology in terms of varying the axonal flow, cytoskeletal organisation, and adenosine triphosphate production in sensory nerves [68][69][70]. Second, the effect of LLLT on inflammation may play a role in the interim alleviation of DH since studies suggested there is a potential relationship between DH and micro-inflammation within dentine-pulp complexes [71][72][73][74].…”

Section: Discussionmentioning

confidence: 99%

Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis

Shan

McGrath

et al. 2021

Clin Oral Invest

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Objective To investigate the treatment efficacy of low-level light therapy on dentin hypersensitivity. Materials and methods Following the PRISMA guideline, six electronic databases supplemented with bibliographies were searched till December 2020. Two reviewers performed the screenings independently with a reliability assessment. Studies fulfilling the pre-registered eligibility criteria were included for risk-of-bias assessment and data synthesis. Results Thirty-five articles ultimately informed this systematic review based on the eligibility criteria and underwent risk-of-bias assessment (ĸ = 0.86). Quantitative results were deduced by meta-analysis of 20 randomised controlled trials: LLLT showed favourable outcomes compared to placebos for immediate (SMD: 1.09, 95% CI: 0.47 to 1.70), interim (SMD: 1.32, 95% CI: 0.41 to 2.23), and persistent efficacies (SMD: 2.86, 95% CI: 1.98 to 3.74). However, substantial heterogeneity existed among included studies (I2: 64–95%). Regarding comparisons with other desensitising strategies, LLLT showed no significant benefits in DH alleviation over others except fluorides for interim efficacy (SMD: 0.31, 95% CI: 0.10 to 0.52) and persistent efficacy (SMD: 0.45, 95% CI: 0.03 to 0.86). Conclusions This systematic review shows that LLLT has positive immediate, interim, and persistent DH-treatment efficacies compared with placebo. No superior treatment effects of LLLT were observed except fluoride agent use. Further studies are warranted—RCTs with low risk of bias, consistent technical settings, comprehensive assessments, and long follow-up periods. Clinical relevance This systematic review bridges a critical research gap by analysing clinical evidence in the DH-alleviating efficacy of LLLT in comparison with placebo and other in-office desensitising strategies.

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Dose-dependent effect of the pulsed Nd:YAG laser in the treatment of crushed sciatic nerve in Wister rats: an experimental model

Cited by 7 publications

References 52 publications

Efficacy of multi-wave locked system laser therapy on nerve regeneration after crushing in Wister rats

Efficacy of multi-wave locked system laser therapy on nerve regeneration after crushing in Wister rats

Effects of Low-Level Laser Therapy and Purified Natural Latex (Hevea brasiliensis) Protein on Injured Sciatic Nerve in Rodents: Morpho-Functional Analysis

Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis

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