Dose-dependent effects of differential rearing on amphetamine-induced hyperactivity

Cain, Mary E.; Mersmann, Marian G.; Gill, Margaret J.; Pittenger, Steven T.

doi:10.1097/fbp.0b013e32835a38ec

Cited by 17 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The similarity in the observed behavior between IC and SC rats compared to EC rats is consistent with recent studies (Wooters et al, 2011; Cain et al, 2012; Gill et al, 2012), and suggests that enrichment is attenuating the response to amphetamine, rather than isolation rearing that is increasing the response to amphetamine.…”

Section: Discussionsupporting

confidence: 89%

The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats.

Arndt

Arnold

Cain

2014

Experimental and Clinical Psychopharmacology

Self Cite

View full text Add to dashboard Cite

Environmental stimuli play a key role in affecting the likelihood to abuse drugs. Environmental enrichment can reduce that likelihood. Importantly, glutamate contributes to both drug reward and rearing-induced changes in the brain. The current study investigated the effects of the Group II metabotropic glutamate receptor (mGluR2/3) agonist, LY-379268 (0.5, 1.0 mg/kg), on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats. Male Sprague-Dawley rats were randomly assigned to one of three environmental conditions post-weaning: enriched (EC), isolated (IC), or standard (SC), where they reared for 30 days. The effect of LY-379268 on acute amphetamine-induced locomotor activity was assessed. Rats were injected with either LY-379268 (0.5, 1.0 mg/kg) or saline prior to an amphetamine (0.5 mg/kg) or saline challenge injection. Rats were also administered amphetamine (0.5 mg/kg) or saline injections prior to 5 locomotor sessions. Following a rest period of 14–15 days, the effects of repeated amphetamine exposure were evaluated using LY-379268 (0.5; 1.0 mg/kg) or saline injections 30 minutes prior to receiving amphetamine (0.5 mg/kg). Results showed that LY-379268 administration dose-dependently attenuated acute amphetamine-induced locomotor activity, with EC rats generally displaying less attenuation compared to IC or SC rats. After repeated amphetamine administrations, the ability of LY-379268 to attenuate the final expression of amphetamine-induced locomotor activity in differentially reared rats was dose dependent. The differing effect of LY-379268 observed in EC rats suggests enrichment-induced glutamatergic alterations that may protect against sensitivity to psychostimulants.

show abstract

Section: Discussionsupporting

confidence: 89%

The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats.

Arndt

Arnold

Cain

2014

Experimental and Clinical Psychopharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enrichment also reduces the locomotor response to low doses of psychostimulants (Bardo et al, 1995; Green et al, 2002). Enrichment decreases acute amphetamine-induced hyperactivity when compared to isolation (Bardo et al 1995; Cain, Mersmann, Gill, & Pittenger, 2012; Gill, Arnold, & Cain, 2012). Enrichment also decreases psychostimulant-induced sensitization across a range of psychostimulants when compared to isolation (Bardo et al, 1995; Cain et al, 2012; Coolon and Cain, 2009; Smith et al, 1997; Wooters et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Differential housing and novelty response: Protection and risk from locomotor sensitization

Garcia

Haddon

Saucier

et al. 2017

Pharmacology Biochemistry and Behavior

Self Cite

View full text Add to dashboard Cite

High novelty seeking increases the risk for drug experimentation and locomotor sensitization. Locomotor sensitization to psychostimulants is thought to reflect neurological adaptations that promote the transition to compulsive drug taking. Rats reared in enrichment (EC) show less locomotor sensitization when compared to rats reared in isolation (IC) or standard conditions (SC). The current research study was designed to test if novelty response contributed locomotor sensitization and more importantly, if the different housing environments could change the novelty response to protect against the development of locomotor sensitization in both adolescence and adulthood. Experiment 1: rats were tested for their response to novelty using the inescapable novelty test (IEN) and pseudorandomly assigned to enriched (EC), isolated (IC), or standard (SC) housing conditions for 30 days. After housing, they were tested with IEN. Rats were then administered amphetamine (0.5 mg/kg) or saline and locomotor activity was measured followed by a sensitization test 14 days later. Experiment 2: rats were tested in the IEN test early adulthood and given five administrations of amphetamine (0.3 mg/kg) or saline and then either stayed in or switched housing environments for 30 days. Rats were then re-tested in the IEN test in late adulthood and administered five more injections of their respective treatments and tested for locomotor sensitization. Results indicate that IC and SC increased the response to novelty. EC housing decreased locomotor response to amphetamine and saline, and SC housing increased the locomotor response to amphetamine. Mediation results indicated that the late adult novelty response fully mediates the locomotor response to amphetamine and saline, while the early adulthood novelty response did not. Conclusions Differential housing changes novelty and amphetamine locomotor response. Novelty response is altered into adulthood and provides evidence that enrichment can be used to reduce drug vulnerability.

show abstract

“…Social interactions additionally enhance the rewarding effects of cocaine (Thiel et al ., 2008) and morphine (Cole et al ., 2013) in laboratory rodents. There is also robust evidence that chronic social isolation of laboratory rodents increases responsiveness to, intake of, and preference for drugs of abuse (e.g., Zimmerberg & Brett; 1992; Phillips et al ., 1994; Raz and Berger, 2010; Cain et al ., 2012; Westenbroek et al ., 2013; Whitaker et al ., 2013; Meyer & Bardo, 2015; Yorgason et al ., 2016). …”

Section: Introductionmentioning

confidence: 99%

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Panksepp

Rodriguez

Ryabinin

2016

Genes Brain and Behavior

View full text Add to dashboard Cite

With its ease of availability during adolescence, sweetened ethanol (‘alcopops’) is consumed within many contexts. We asked here whether genetically based differences in social motivation are associated with how the adolescent social environment impacts voluntary ethanol intake. Mice with previously described differences in sociability (BALB/cJ, C57BL/6J, FVB/NJ and MSM/MsJ strains) were weaned into isolation or same-sex pairs (postnatal day 21), and then given continuous access to two fluids on postnatal days 34–45: One containing water and the other containing a ascending series of saccharin-sweetened ethanol (3-to-6-to-10%). Prior to the introduction of ethanol (postnatal days 30–33), increased water and food intake was detected in some of the isolation-reared groups, and controls indicated that isolated mice also consumed more ‘saccharin-only’ solution. Voluntary drinking of ‘ethanol-only’ was also higher in a subset of the isolated groups on postnatal days 46–49. However, sweetened ethanol intake was increased in all isolated strain-by-sex combinations irrespective of genotype. Surprisingly, blood ethanol concentration was not different between these isolate and socially housed groups 4 hours into the dark phase. Using lickometer-based measures of intake in FVB mice, we identified that a predominance of increased drinking during isolation transpired outside of the typical circadian consumption peak, occurring ≈8.5 hours into the dark phase, with an associated difference in blood ethanol concentration. These findings collectively indicate that isolate housing leads to increased consumption of rewarding substances in adolescent mice independently of their genotype, and that for ethanol this may be due to when individuals drink during the circadian cycle.

show abstract

Dose-dependent effects of differential rearing on amphetamine-induced hyperactivity

Cited by 17 publications

References 0 publications

The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats.

The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats.

Differential housing and novelty response: Protection and risk from locomotor sensitization

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Contact Info

Product

Resources

About