2023
DOI: 10.3390/cells13010039
|View full text |Cite
|
Sign up to set email alerts
|

Dose-Dependent Effects of Radiation on Mitochondrial Morphology and Clonogenic Cell Survival in Human Microvascular Endothelial Cells

Li Wang,
Rafael Rivas,
Angelo Wilson
et al.

Abstract: To better understand radiation-induced organ dysfunction at both high and low doses, it is critical to understand how endothelial cells (ECs) respond to radiation. The impact of irradiation (IR) on ECs varies depending on the dose administered. High doses can directly damage ECs, leading to EC impairment. In contrast, the effects of low doses on ECs are subtle but more complex. Low doses in this study refer to radiation exposure levels that are below those that cause immediate and necrotic damage. Mitochondria… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 87 publications
0
1
0
Order By: Relevance
“…Similarly, radiation therapy is known to affect mitochondrial integrity [ 50 ]. High doses of ionizing radiation (IR) caused mitochondrial fragmentation and cellular senescence [ 51 ]. Conversely, the development of resistance to anticancer drugs or radiation in certain cancer cell populations is often marked by distinct alterations in mitochondrial dynamics [ 52 , 53 ].…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, radiation therapy is known to affect mitochondrial integrity [ 50 ]. High doses of ionizing radiation (IR) caused mitochondrial fragmentation and cellular senescence [ 51 ]. Conversely, the development of resistance to anticancer drugs or radiation in certain cancer cell populations is often marked by distinct alterations in mitochondrial dynamics [ 52 , 53 ].…”
Section: Discussionmentioning
confidence: 99%